Systematic (IUPAC) name | |
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3-hydroxy- 14-methoxy- 5,17-dimethyl- 7,8-dihydro- 4,5α- epoxy- morphinan- 6-one | |
Clinical data | |
Pregnancy cat. | ? |
Legal status | ? |
Identifiers | |
CAS number | 131575-03-6 |
ATC code | ? |
PubChem | CID 5486940 |
ChemSpider | 4589140 |
ChEMBL | CHEMBL326684 |
Synonyms | 14-Methoxymetopon |
Chemical data | |
Formula | C19H23NO4 |
Mol. mass | 329.39 g/mol |
SMILES | eMolecules & PubChem |
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14-Methoxymetopon is an opiate analogue that is a derivative of metopon which has been substituted with a methoxy group at the 14-position. It is a highly potent analgesic drug that is around 500x stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine.[1] It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs.[2] This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regards to some effects such as analgesia, a ceiling effect is seen on other effects such as constipation and respiratory depression.[3]