Prostaglandin D2

Prostaglandin D2
Identifiers
CAS number 41598-07-6
PubChem 448457
MeSH Prostaglandin+D2
IUPHAR ligand 1881
Properties
Molecular formula C20H32O5
Molar mass 352.465 g/mol
 Y (verify) (what is: Y/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR, as well as CRTH2.[1][2] It is a major prostaglandin produced by mast cells – recruits Th2 cells, eosinophils, basophils. In mammalian organs, large amounts of PGD2 are found in the brain, in mast cells and found nowhere else. It is critical to development of allergic diseases such as asthma.

Effects

See also

References

  1. ^ Saito S, Tsuda H, Michimata T (May 2002). "Prostaglandin D2 and reproduction". American Journal of Reproductive Immunology (New York, N.Y. : 1989) 47 (5): 295–302. PMID 12148545. http://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1046-7408&date=2002&volume=47&issue=5&spage=295. Retrieved 2011-04-09. 
  2. ^ Pettipher R, Hansel TT (2008). "Antagonists of the prostaglandin D2 receptor CRTH2". Drug News & Perspectives 21 (6): 317–22. doi:10.1358/dnp.2008.21.6.1246831. PMID 18836589. http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=3&p_RefId=1246831. Retrieved 2011-04-09.