Bedbug

Bedbug
Cimex lectularius
Scientific classification
Kingdom: Animalia
Phylum: Arthropoda
Class: Insecta
Order: Hemiptera
Suborder: Heteroptera
Infraorder: Cimicomorpha
Superfamily: Cimicoidea
Family: Cimicidae
Latreille, 1802
Subfamilies, Genera & Species

Subfamily Afrociminae

  • Genus Afrocimex
    • Afrocimex constrictus

Subfamily Cimicinae

  • Genus Bertilia
  • Genus Cimex
    • Cimex adjunctus
    • Cimex antennatus
    • Cimex brevis
    • Cimex columbarius
    • Cimex incrassatus
    • Cimex latipennis
    • Cimex lectularius
    • Cimex hemipterus (C. rotundatus)
    • Cimex pilosellus
    • Cimex pipistrella
  • Genus Oeciacus
    • Oeciacus hirundinis
    • Oeciacus vicarius
  • Genus Paracimex
  • Genus Propicimex

Subfamily Cacodminae

  • Genus Aphrania
  • Genus Cacodomus
  • Genus Crassicimex
  • Genus Leptocimex
    • Leptocimex boueti
  • Genus Loxaspis
  • Genus Stricticimex

Subfamily Haematosiphoninae

  • Genus Caminicimex
  • Genus Cimexopsis
    • Cimexopsis nyctalis
  • Genus Haematosiphon
    • Haematosiphon inodorus
  • Genus Hesperocimex
    • Hesperocimex coloradensis
    • Hesperocimex sonorensis
  • Genus Ornithocoris
    • Ornithocoris pallidus
    • Ornithocoris toledoi
  • Genus Psitticimex
  • Genus Synxenoderus
    • Synxenoderus comosus

Subfamily Latrocimicinae

  • Genus Latrocimex

Subfamily Primicimicinae

  • Genus Bucimex
  • Genus Primicimex
    • Primicimex cavernis

Bedbugs (or bed bugs) are small, elusive, parasitic insects of the family Cimicidae. The term usually refers to species that feed preferentially on human blood; all insects in this family live by feeding exclusively on the blood of warm-blooded animals.[1][2] The name 'bedbug' is derived from the insect's preferred habitat of infesting houses and especially beds or other common areas where people may sleep. Bedbugs, though not strictly nocturnal, are mainly active at night and are capable of feeding unnoticed on their hosts.

Bedbugs have been known by a variety of names including wall louse, mahogany flat, crimson rambler, heavy dragoon, chinche and redcoat.[3]

Largely eradicated as pests in the developed world (largely through the use of DDT) in the early 1940s, bedbugs have been resurgent since about 1995.[4]

Contents

Biology

Adult bedbugs are reddish-brown, flattened, oval, and wingless. Bedbugs have microscopic hairs that give them a banded appearance. Adults grow to 4–5 mm in length and 1.5–3 mm wide. Newly hatched nymphs are translucent, lighter in color and become browner as they moult and reach maturity.

Bedbugs use pheromones and kairomones to communicate regarding nesting locations, attacks, and reproduction.

The life span of bedbugs varies by species and is also dependent on feeding.

Environmental range

The common bedbug (Cimex lectularius) is the species best adapted to human environments. It is found in temperate climates throughout the world. Other species include Cimex hemipterus, found in tropical regions, which also infests poultry and bats, and Leptocimex boueti, found in the tropics of West Africa and South America, which infests bats and humans. Cimex pilosellus and Cimex pipistrella primarily infest bats, while Haematosiphon inodora, a species of North America, primarily infests poultry.[5]

Bedbugs can survive a wide range of temperatures and atmospheric compositions. Below 16.1 °C (61.0 °F), adults enter semi-hibernation and can survive longer.[6] Bedbugs can survive for at least five days at −10 °C (14.0 °F) but will die after 15 minutes of exposure to −32 °C (−26 °F).[7] They show high desiccation tolerance, surviving low humidity and a 35–40 °C range even with loss of one-third of body weight; earlier life stages are more susceptible to drying out than later ones.[8] The thermal death point for C. lectularius is high: 45 °C (113 °F), and all stages of life are killed by 7 minutes of exposure to 46 °C (115 °F).[7] Bedbugs apparently cannot survive high concentrations of carbon dioxide for very long; exposure to nearly-pure nitrogen atmospheres, however, appears to have relatively little effect even after 72 hours.[9]

Feeding habits

Scanning electron micrograph (SEM) of Cimex lectularius, digitally colorized with the insect’s skin-piercing mouthparts highlighted in purple and red.

Bedbugs are obligatory hematophagous (bloodsucking) insects. Most species only feed on humans when other prey are unavailable.[10][11][12] Bedbugs are attracted to their hosts primarily by carbon dioxide, secondarily by warmth, and also by certain chemicals.[13]

A bedbug pierces the skin of its host with two hollow feeding tubes. With one tube it injects its saliva, which contains anticoagulants and anesthetics, while with the other it withdraws the blood of its host. After feeding for about five minutes, the bug returns to its hiding place.[2]

Although bedbugs can live for a year without feeding,[14] they normally try to feed every five to ten days. In cold weather, bedbugs can live for about a year; at temperatures more conducive to activity and feeding, about 5 months.[15]

At the 57th Annual Meeting of the Entomological Society of America in 2009, it was reported that newer generations of pesticide-resistant bedbugs in Virginia could survive only two months without feeding.[16]

DNA from human blood meals from bed bugs can be recovered for up to 90 days, which may allow bed bugs to be used for forensic purposes for identifying who the bed bugs have been feeding on. [17] [18]

Predators

Natural enemies of bedbugs include the masked hunter (also known as "masked bedbug hunter"),[19] cockroaches,[20] ants, spiders, mites, and centipedes. The Pharaoh ant's (Monomorium pharaonis) venom is lethal to bedbugs. Biological pest control is not very practical for eliminating bedbugs from human dwellings.[7]

Reproduction

A bedbug (Cimex lectularius) traumatically inseminates another

All bedbugs mate by traumatic insemination.[1][21] Because the female has no genital opening, the male pierces her abdomen with his hypodermic genitalia and ejaculates into the body cavity. Especially desperate males sometimes mistake other males for females and fatally wound the latter in the abdomen.[22]

The "bedbug alarm pheromone" consists of (E)-2-octenal and (E)-2-hexenal. It is released when a bedbug is disturbed, as during an attack by a predator. A 2009 study demonstrated that the alarm pheromone is also released by male bedbugs to repel other males who attempt to mate with them.[23]

C. lectularius and C. hemipterus will mate with each other given the opportunity, but the eggs then produced are usually sterile. In a 1988 study, 1 egg out of 479 was fertile and resulted in a hybrid, C. hemipterus × lectularius.[24][25]

Life stages

Slide of Cimex lectularius
Bedbug (4 mm length; 2.5 mm width), shown in a film roll plastic container. On the right is the recently sloughed skin from its nymph stage.

Bedbugs will shed their skins through a molting process (ecdysis) throughout multiple stages of their lives. The discarded outer-shells look as clear, empty exoskeletons of the bugs themselves. Bedbugs must molt six times before becoming fertile adults.[26]

Pesticide resistance

With the widespread use of DDT in the 1940s and 1950s, bedbugs mostly disappeared from the developed world in the mid-20th century,[27] though infestations remained common in many other parts of the world.[15] Rebounding populations present a challenge because of developed resistance to various pesticides including DDT, and organophosphates. [28] [29] Bed bug populations in Arkansas have been found to be highly resistant to DDT, with an LD50 of more than 100,000 PPM [30] DDT was seen to make bedbugs more active in studies done in Africa.[31]

Because some bedbug populations have developed a resistance to pyrethroid insecticides, there is growing interest in both synthetic pyrethroid and pyrrole insecticide chlorfenapyr; insect growth regulators such as hydroprene (Gentrol) are sometimes used.[26]

Bites

A typical bedbug bite.

Cimicosis is a skin condition caused by bedbug bites.[32]:446 Individual responses vary greatly. In about 50% of cases,[33] there is no visible sign of bites, and for those who do have a visible sign, it varies in size and itchiness, greatly increasing the difficulty of identifying and eradicating infestations.

Serious bedbug infestations and chronic attacks can cause anxiety, stress, and insomnia. Development of refractory delusional parasitosis is possible, as victims develop an overwhelming obsession with bedbugs.[34]

A bedbug nymph feeding on host

Patients given systemic corticosteroids and antihistamines for the itching associated with bites will still have visible signs of bites. Topical corticosteroids, such as hydrocortisone, can reduce lesions and decrease itching.[35]

The application of hot water may relieve symptoms.[36] The water temperature should be about 50 °C (122 °F), or this procedure may aggravate the symptoms. Disagreement exists as to why heat causes symptoms to abate. Heat might overwhelm the nerve endings that signal itch; it might neutralize the chemical causing inflammation, or it might trigger a large release of histamine, causing a temporary histamine deficit in the area.

Disease transmission

Bedbugs would seem to have all the prerequisites for passing diseases from one host to another, and at least twenty-seven known pathogens (some estimates are as high as forty-one) are capable of living inside a bedbug or on its mouthparts, yet there are no known cases of such transmission. Extensive laboratory testing indicates that bedbugs are unlikely to pass disease from one person to another.[33][37]

Other effects on health

The salivary fluid injected by bedbugs can cause skin to become irritated and inflamed, although individuals can differ in their sensitivity. A few cases of bullous eruptions have been reported.[38][39] Anaphylactoid reactions from the injection of serum and other nonspecific proteins are observed and the saliva of the bedbugs may cause anaphylactic shock, though rarely.[40] In rare cases of intense and neglected infestation, sustained feeding by bedbugs may lead to anemia.[41] Secondary bacterial infection (i.e., infections from scratching itchy skin too much) are possible.[26] Systemic poisoning may occur if the bites are numerous.[42]

The World Health Organization reported in 2008 that bedbugs may cause bronchial asthma through the release of airborne allergens and that numerous bedbug bites may cause victims to become more susceptible to other diseases, as well as causing "general malaise".[43]

History

An 1860 engraving of parts of a bedbug. A. Intestines.—B. Antenna of the Male.—C Eye.—D. Haustellum, or Sucker, closed.—E. Side view of Sucker.—F. Under Part of Head.—G. Under Lip.—GG. Hair of the Tube, and outside Cases.—H. Egg-Bag.—I. Worm emerging from the Eggs

C. lectularius may have originated in the Middle East, in caves inhabited by bats and humans.[11]

Bedbugs were mentioned in ancient Greece as early as 400 BC (later mentioned by Aristotle). Pliny's Natural History, first published c. 77 AD in Rome, claimed that bedbugs had medicinal value in treating ailments such as snake bites and ear infections. (Belief in the medicinal use of bedbugs persisted until at least the 18th century, when Guettard recommended their use in the treatment of hysteria.[44]) Bedbugs were first mentioned in Germany in the 11th century, in France in the 13th century, and in England in 1583,[11] though they remained rare in England until 1670. It was believed by some in the 18th century that bedbugs had been brought to London with supplies of wood to rebuild the city after the Great Fire of London (1666). Giovanni Antonio Scopoli noted their presence in Carniola (roughly equivalent to present-day Slovenia) in the 18th century.[45][46]

Bedbugs were known at least as early as 1726 in Jamaica.[47]

Eighteenth and 19th century Europeans believed bedbugs to feed on the sap of certain trees (especially fir), paste (which may have included tree sap), other insects, and Acari.[48][49]

Prior to the mid-twentieth century, bedbugs were very common. According to a report by the UK Ministry of Health, in 1933 there were many areas where all the houses had some degree of bedbug infestation.[50]

Traditional control methods

Plants traditionally used as bedbug repellents include black cohosh (Actaea racemosa), Pseudarthria hookeri, and Laggera alata (Chinese yángmáo cǎo | 羊毛草), though information about their effectiveness is lacking.[7] Eucalyptus saligna oil was reported by some Zairean researchers to kill bedbugs, among other insects.[51][52]

In the 18th century, turpentine was used in combination with henna (Lawsonia inermis, aka camphire) flowers and alcohol, as an insecticide that also reputedly killed bedbug eggs.[53]

Other items that were believed to kill bedbugs in the early 19th century include "infused oil of Melolontha vulgaris" (presumably a kind of cockchafer), fly agaric (Amanita muscaria), Actaea spp. (e.g. black cohosh), tobacco, "heated oil of Terebinthina" (i.e. true turpentine), wild mint (Mentha arvensis), narrow-leaved pepperwort (Lepidium ruderale), Myrica spp. (e.g. bayberry), Robert Geranium (Geranium robertianum), bugbane (Cimicifuga spp.), "herb and seeds of Cannabis", "Opulus" berries (possibly a kind of maple, or European cranberrybush), masked hunter bugs (Reduvius personatus), "and many others."[54] In the mid-19th century, smoke from peat fires was recommended.[55]

The use of black pepper to repel bedbugs is attested in George Orwell's 1933 non-fiction book Down and Out in Paris and London.

Dusts have been used to ward off insects from grain storage for centuries, including "plant ash, lime, dolomite, certain types of soil, and diatomaceous earth (DE) or Kieselguhr".[56] Of these, diatomaceous earth in particular has seen a revival as a non-toxic (when in amorphous form) residual pesticide for bedbug abatement. Insects exposed to diatomaceous earth may take several days to die.[56]

Basket-work panels were put around beds and shaken out in the morning, in the UK and in France in the 19th century. Scattering leaves of plants with microscopic hooked hairs around a bed at night, then sweeping them up in the morning and burning them, was a technique reportedly used in Southern Rhodesia and in the Balkans.[15]

Global resurgence

Bedbug cases have been on the rise across the world since the mid-1990s. Figures from one London borough show reported bedbug infestations doubling each year from 1995 to 2001. There is also evidence of a previous cycle of bedbug infestations in the U.K. in the mid-1980s.[57] The U.S. National Pest Management Association reported a 71% increase in bedbug calls between 2000 and 2005.[58] The Steritech Group, a pest-management company based in Charlotte, North Carolina, claimed that 25% of the 700 hotels they surveyed between 2002 and 2006 needed bedbug treatment. The resurgence led the United States Environmental Protection Agency to hold a National Bed Bug Summit in 2009.[59]

The cause of this resurgence is still uncertain, but it is thought to be related to increased international travel,[60][61] the use of new pest-control methods that do not affect bedbugs,[62] and increasing pesticide resistance.[63]

One recent theory about bedbug reappearance involves potential geographic epicentres. Investigators have found high populations of bed bugs at poultry facilities in Arkansas. Poultry workers at these facilities may be spreading bedbugs, unknowingly carrying them to their places of residence and elsewhere after leaving work.[64] [65]

Blood-fed Cimex lectularius (Note the differences in color with respect to digestion of blood meal)

Bedbug pesticide-resistance appears to be increasing dramatically. Bedbug populations sampled across the U.S. showed a tolerance for pyrethroids several thousands of times greater than laboratory bedbugs.[58] New York City bed bugs have been found to be 264 times more resistant to deltamethrin than Florida bedbugs due to nerve cell mutations.[66] Another problem with current insecticide use is that the broad-spectrum insecticide sprays for cockroaches and ants that are no longer used had a collateral impact on bedbug infestations. Recently, a switch has been made to bait insecticides that have proven effective against cockroaches but have allowed bedbugs to escape the indirect treatment.[50]

A population genetics study of bed bugs in the United States, Canada, and Australia using a mitochondrial DNA marker found high levels of genetic variation. [67] This suggests that the studied bed bug populations did not undergo a genetic bottleneck as one would expect from insecticide control during the 1940s and 1950s, but instead, that populations may have been maintained on other hosts such as birds and bats. In contrast to the high amount of genetic variation observed with the mitochondrial DNA marker, no genetic variation in a nuclear rRNA marker was observed. This suggests increased gene flow of previously isolated bed bug populations, and given the absence of barriers to gene flow, the spread of insecticide resistance may be rapid.

Social impact

The rise in infestations has been hard to track because bedbugs are not an easily identifiable problem. Most of the reports are collected from pest-control companies, local authorities, and hotel chains.[50] Therefore, the problem may be more severe than is currently believed.[35]

Bedbugs are an increasing cause for litigation.[68] Courts have, in some cases, exacted large punitive damage judgments on some hotels.[69][70][71] Many of Manhattan's Upper East Side home owners have been afflicted, but they tend to be silent publicly in order not to ruin their property values and be seen as suffering a blight typically associated with the lower classes.[72]

Numbers of reported incidents in New York City rose from 500 in 2004 to 10,000 in 2009. Some of those afflicted have been stigmatized as a result of the perceived uncleanliness and risk of spreading the insects.[73]

Infestation vectors

An engorged female bedbug (Cimex lectularius) with eggs, discovered in the screw hole of a wooden bed frame

Dwellings can become infested with bedbugs in a variety of ways:

Bedbugs can infest nursing homes, furniture rental stores, hospitals, jails, homeless shelters, movie theaters, cruise ships, public housing, moving vehicles, and public transportation.

Nesting locations

Bedbugs can be found on their own but often congregate once established. They usually remain close to hosts, commonly in or near beds or couches. Nesting locations can vary greatly, however, including luggage, vehicles, furniture and bedside clutter. Bedbugs may also nest near animals that have nested within a dwelling, such as bats, birds, or rodents.

Detection

Bedbugs are elusive and usually nocturnal, which can make them hard to spot. Bedbugs often lodge unnoticed in dark crevices, and eggs can be nestled in fabric seams. Aside from bite symptoms, signs include fecal spots, blood smears on sheets, and moults.

Attractant devices for detection use heat and/or carbon dioxide.[16]

Bed bug detection dogs are trained to pinpoint infestations, with an accuracy of 97.5%, and often in minutes where a pest control practitioner might need an hour.[76][7] In the United States, about 100 dogs are used to find bedbugs as of mid-2009.[77]

See also

References

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  2. ↑ 2.0 2.1 "What Are Bed Bugs? How To Kill Bed Bugs". Medical News Today. MediLexicon International Ltd. 20 Jul 2009. http://www.medicalnewstoday.com/articles/158065.php. Retrieved May 27, 2010. 
  3. ↑ Capinera, John L. (17 Sep 2008). Encyclopedia of Entomology, Volume 1 (2nd ed.). Springer. pp. 405–417. ISBN 1402062427.  (Article: "Bed Bugs (Hemiptera: Cimicidae: Cimex spp.", Dini Miller, Virginia Tech University, VA
  4. ↑ Kilpenen, O.; Vagn Jensen, K-M.; Kristensen, M.. Bed Bug Problems in Denmark, with a European Perspective. pp. 395–399. http://www.icup.org.uk/reports/ICUP858.pdf. Retrieved 27 May 2010.  In Robinson, WH; Bajomi, D. (eds) (2008). Proceedings of the Sixth International Conference on Urban Pests. Hungary: OOK-Press Kft. 
  5. ↑ Cranshaw, W.S.; Camper, M.; Peairs, F.B. (Feb 2009). "Bat Bugs and Bed Bugs". Colorado State University Extension. http://www.ext.colostate.edu/PUBS/INSECT/05574.html. Retrieved 27 May 2010. 
  6. ↑ "Augustine Exterminators". Augustine Exterminators. http://www.augustineexterminators.com/galleryDetail.asp?gallery_id=26. Retrieved 2010-09-01. 
  7. ↑ 7.0 7.1 7.2 7.3 7.4 IPM Practitioner, XXIX(3/4), March/April 2007 http://www.birc.org/MarApril2007.pdf
  8. ↑ Benoit, J. B.; del Grosso, N.; Yoder, J. A.; Denlinger, D. L. (2007). "Resistance to dehydration between bouts of blood feeding in the bedbug, Cimex lectularius, is enhanced by water conservation, aggregation, and quiescence". American Journal of Tropical Medicine and Hygiene 76 (5): 987–993. ISSN 0002-9637. PMID 17488928. http://www.ajtmh.org/cgi/content/full/76/5/987. Retrieved 27 May 2010. 
  9. ↑ Herrmann, J.; Adler, C.; Hoffmann, G.; Reichmuth, C. (1999). "Efficacy of controlled atmospheres on Cimex lectularius (L.) (Heteroptera: Cimicidae) and Argas reflexus Fab. (Acari: Argasidae)". In Robinson, Wm H.; Rettich, F.; Rambo, G.W.. Proceedings of the 3rd International Conference on Urban Pests. Hronov, Czech Republic: Grafické Závody. p. 637. http://www.icup.org.uk/reports/ICUP511.pdf. Retrieved 31 May 2010.  (abstracted from a poster presentation in Prague, Jul 19-22)
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  12. ↑ "Family CIMICIDAE". Australian Biological Resources Study: Australian Faunal Directory. Department of the Environment, Water, Heritage and the Arts (Australia). 2008. http://www.environment.gov.au/biodiversity/abrs/online-resources/fauna/afd/taxa/CIMICIDAE. Retrieved 27 May 2010. 
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  14. ↑ Loye, Jenella E. (1985). "The life history and ecology of the cliff swallow bug, Oeciacus vicarius (Hemiptera : Cimicidae)". Ent med. et Parasitol (Cah. OSTROM) 32 (2): 133–139. ISSN 0029-7224. http://horizon.documentation.ird.fr/exl-doc/pleins_textes/cahiers/entomo/28405.pdf. Retrieved 26 May 2010.  N.B. This paper reports an abandoned swallow colony with Oeciacus vicarius surviving three consecutive years. However, that does not preclude the availability of other species (e.g., bats, other mammals, other birds) to fall back on for occasional feeding.
  15. ↑ 15.0 15.1 15.2 Boase, C. (2001), "Bedbugs - back from the brink", Pesticide Outlook 12 (4): 159–162, doi:10.1039/b106301b, http://www.rsc.org/delivery/_ArticleLinking/DisplayArticleForFree.cfm?doi=b106301b, retrieved 2010-05-27 
  16. ↑ 16.0 16.1 Milius, Susan (16 Jan 2010). "Do-it-yourself bed-bug detector". Science News. Society for Science and the Public. p. 88. http://www.sciencenews.org/view/generic/id/51188/title/Do-it-yourself_bed-bug_detector. Retrieved 27 May 2010.  citing Polanco-Pinzón, Andrea; et al. (2009). "Survivorship and growth potential of modern bed bug populations (Cimex lectularius) in the United States". Conference proceedings of 57th Annual Meeting (Entomological Society of America). 
  17. ↑ Szalanski, A.L., J.W. Austin, J.A. McKern, C.D. Steelman and D. Miller. 2006. Time course analysis of bed bug, Cimex lectularius L., (Hemiptera: Cimicidae) blood meals using PCR. Journal of Agricultural and Urban Entomology 23: 237-241.
  18. ↑ Szalanski, A.L., J.W. Austin, J.A. McKern, D. Miller, C.D. Steelman, and R.E. Gold. 2006. Isolation and characterization of human DNA from the bed bug, Cimex lectularius L. (Heteroptera: Cimicidae). Journal of Agricultural and Urban Entomology 23: 189-194.
  19. ↑ Hahn, Jeffrey (November 1999). "Masked hunters". Yard & Garden Briefs. University of Minnesota Extension Service: Yard & Garden Clinic. http://www.extension.umn.edu/yardandgarden/ygbriefs/e608maskedhunter.html. Retrieved 27 May 2010. 
  20. ↑ Encyclopedia Americana, 1996 ed., v. 3, p. 413
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  23. ↑ Ryne, C. In press. "Homosexual interactions in bed bugs: Alarm pheromones as male recognition signals." Animal Behaviour. doi: 10.1016/j.anbehav.2009.09.033 Cited in Cited in Science News, November 21st, 2009; Vol.176 #11 (p. 13) "Scent of alarm identifies male bed bugs" by Susan Milius. http://www.sciencenews.org/view/generic/id/48927/title/Scent_of_alarm_identifies_male__bed_bugs
  24. ↑ "Production of a hybrid between the bedbugs Cimex hemipterus and Cimex lectularius". Medical and Veterinary Entomology (The Royal Entomological Society) 2 (3): 297–300. July 1988. doi:10.1111/j.1365-2915.1988.tb00199.x. http://www.ncbi.nlm.nih.gov/pubmed/2980186. 
  25. ↑ Walpole, Debra E.; Newberry, K. (July 1988). "A field study of mating between two species of bedbug in northern KwaZulu, South Africa". Medical and Veterinary Entomology (The Royal Entomological Society) 2 (3): 293–296. doi:10.1111/j.1365-2915.1988.tb00198.x. 
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  30. ↑ C. Dayton Steelman, Allen L. Szalanski, Rebecca Trout, Jackie A. McKern, Cesar Solorzano & James W. Austin (2008). "Susceptibility of the bed bug Cimex lectularius L. (Hemiptera: Cimicidae) to selected insecticides". Journal of Agricultural and Urban Entomology 25 (1): 45–51. doi:10.3954/1523-5475-25.1.41. 
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  32. ↑ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0. 
  33. ↑ 33.0 33.1 Jerome Goddard & Richard deShazo (2009). "Bed bugs (Cimex lectularius) and clinical consequences of their bites". Journal of the American Medical Association 301 (13): 1358–1366. doi:10.1001/jama.2009.405. PMID 19336711. http://jama.ama-assn.org/cgi/content/short/301/13/1358. 
  34. ↑ Susan C. Jones (January 2004). "Extension Fact Sheet "Bed Bugs, Injury"". Ohio State University. http://ohioline.osu.edu/hyg-fact/2000/pdf/2105.pdf. 
  35. ↑ 35.0 35.1 Scarupa, M.D.; Economides, A. (2006). "Bedbug bites masquerading as urticaria". Journal of Allergy and Clinical Immunology 117 (6): 1508–1509. doi:10.1016/j.jaci.2006.03.034. http://linkinghub.elsevier.com/retrieve/pii/S0091674906007408. 
  36. ↑ Sulzberger, M. B., et al. Dermatology: Diagnosis and Treatment. Chicago: Yearbook, 1961; p. 94
  37. ↑ Sean Rollo http://thebedbugresource.com/?page_id=50#6 The Bed Bug Resource "Can bed bugs pass diseases?" 2007
  38. ↑ Liebold, K; Schliemann-Willers, S; Wollina, U (Jul 2003). "Disseminated bullous eruption with systemic reaction caused by Cimex lectularius". J Eur Acad Dermatol Venereol (Blackwell Publishing) 17 (4): 461–3. doi:10.1046/j.1468-3083.2003.00778.x. 
  39. ↑ Leverkus, Martin; Jochim, Ryan C.; Schad, Susanne; et al. (2006). "Bullous allergic hypersensitivity to bed bug bites mediated by IgE against salivary nitrophorin.". J. Invest. Dermatol. 126: 91–96. PMID 16417223. 
  40. ↑ Bircher, Andreas J (2005). "Systemic Immediate Allergic Reactions to Arthropod Stings and Bites". Dermatology (Blackwell Publishing) 210: 119–127. doi:10.1159/000082567. 
  41. ↑ Pritchard, M. Jane; Hwang, Stephen W. (Sep 2001). "Severe anemia from bedbugs". Canadian Medical Association Journal 181 (5). doi:10.1503/cmaj.090482. http://canadianmedicaljournal.ca/cgi/content/full/181/5/287. 
  42. ↑ Encyclopedia Americana, 1996 ed., v. 3, p. 431
  43. ↑ "The Public Health Significance of Urban Pests" http:.//www.euro.who.int/en/what-we-publish/abstracts/public-health-significance-of-urban-pests
  44. ↑ William Smith and Charles Anthon, A dictionary of Greek and Roman antiquities, 1847, pp. 252-253 http://books.google.com/books?id=41oMAAAAYAAJ&dq=cimex&source=gbs_navlinks_s
  45. ↑ "That soon after the Fire of London, in some of the new-built Houses they were observ'd to appear, and were never noted to have been seen in the old, tho' they were then so few, as to be little taken notice of; yet as they were only seen in Firr-Timber, 'twas conjectured they were then first brought to England in them; of which most of the new Houses were partly built, instead of the good Oak destroy'd in the old." John Southall, A Treatise of Buggs [sic], pp. 16-17. http://www.archive.org/details/atreatisebuggss00soutgoog
  46. ↑ "According to Scopoli's 2nd work (loc. cit.), found in Carniola and adjoining regions. According to Linnaeus' 2nd work on exotic insects (loc. cit.), before the era of health, already in Europe, seldom observed in England before 1670." Johann Friedrich Wolff and Johann Philip Wolff, Icones Cimicum descriptionibus illustratae, fourth fascicle (1804), p. 127. http://www.archive.org/details/iconescimicumdes00wolf
  47. ↑ John Southall, A Treatise of Buggs [sic], pp. 16-17. http://www.archive.org/details/atreatisebuggss00soutgoog
  48. ↑ "Their beloved Foods are Blood, dry'd Paste, Size, Deal [fir], Beach [beech], Oiler, and some other Woods, the Sap of which they lick; and on any one of these will they live the year round. Oak, Walnut, Cedar and Mahogoney they will not feed upon; all Pairs I put up with those Woods for Food, having been soon starved to death." John Southall, A Treatise of Buggs, pp. 23-24 http://www.archive.org/details/atreatisebuggss00soutgoog
  49. ↑ "Many years ago I found numerous specimens in hidden places among wooden beams, where without a doubt Acari [mites and ticks] and a few other insects supplied them with nourishment." Johann Friedrich Wolff and Johann Philip Wolff, Icones Cimicum descriptionibus illustratae, fourth fascicle, 1804, p. 127 http://www.archive.org/details/iconescimicumdes00wolf
  50. ↑ 50.0 50.1 50.2 Boase, Clive J. (April 2004), "Bed-bugs – reclaiming our cities", Biologist 51: 1–4, http://scholar.google.com/scholar_alerts?view_op=create_alert_options, retrieved 2010-06-07 
  51. ↑ Schaefer, C.W.; Pazzini, A.R. (28 July 2000). Heteroptera of Economic Importance. Boca Raton, FL: CRC Press. p. 525. ISBN 0849306957. http://books.google.com/books?id=AVcBI0GL-fQC&lpg=PP1&ots=xVXyjFeZPR&dq=Heteroptera%20of%20Economic%20Importance&pg=PA525#v=onepage&q=eucalyptus&f=false. 
  52. ↑ Kambu, Kabangu; Di Phanzu, N.; Coune, Claude; Wauters, Jean-Noël; Angenot, Luc (1982). "Contribution à l'étude des propriétés insecticides et chimiques d'Eucalyptus saligna du Zaïre (Contribution to the study of insecticide and chemical properties of Eucalyptus saligna from Zaire ( Congo))". Plantes Médicinales et Phytothérapie (Paris: Jouve) 16 (1): 34–38. http://hdl.handle.net/2268/14438. 
  53. ↑ Rictor Norton, Early Eighteenth-Century Newspaper Reports: A Sourcebook, "Getting Rid of Bed-Bugs", 18 November 2001, updated 30 November 2001 <http://grubstreet.rictornorton.co.uk/bedbugs.htm>
  54. ↑ Johann Friedrich Wolff and Johann Philip Wolff, Icones Cimicum descriptionibus illustratae, fourth fascicle (1804), p. 127. http://www.archive.org/stream/iconescimicumdes00wolf#page/n163/mode/2up
  55. ↑ (no byline) (17 June 1848). "Peat and peat mosses". Scientific American 3 (39): 307. http://digital.library.cornell.edu/cgi/t/text/pageviewer-idx?c=scia&cc=scia&idno=scia0003-33&node=scia0003-33:1&frm=frameset&view=image&seq=309. Retrieved 26 May 2010. 
  56. ↑ 56.0 56.1 Hill, Stuart B. (May 1986). "Diatomaceous Earth: A Non Toxic Pesticide". Macdonald J. (Ste-Anne de Bellevue, QC: Macdonald College) 47 (2): 14–42. http://eap.mcgill.ca/publications/eap4.htm. Retrieved 26 May 2010. 
  57. ↑ King, F; Dick, I; Evans, P. Bed bugs in Britain. Parasitology Today. Vol. 5, no. 4, pp. 100–102. 1989. In the period 1985–1986, the Institution of Environmental Health Officers reported treating 7,771 infestations in England and Wales, and 6,179 infestations in 1986–1987. There were also reports of infestations in Belfast and in Scotland.
  58. ↑ 58.0 58.1 Voiland, Adam "You May not be Alone" U.S. News & World Report 7/16/2007, Vol. 143, Issue 2, p53–54.
  59. ↑ "National Bed Bug Summit". United States Environmental Protection Agency. http://www.epa.gov/pesticides/ppdc/bedbug-summit/. Retrieved 2009-04-22. 
  60. ↑ Doggett, S.L.; Geary, M.J.; Russell, R.C. (2004), "The Resurgence of Bed Bugs in Australia: With Notes on Their Ecology and Control", Environmental Health-Australian Institute of Environmental Health 4: 30–38, ISSN 1444-5212, http://medent.usyd.edu.au/bedbug/papers/jeh_bedbug_resurgence.pdf, retrieved 2010-05-31 
  61. ↑ Masetti, Massimo and Bruschi, Fab hell rizio, "Bedbug Infestations recorded in Central Italy", Parasitology International Volume 56, Issue 1, March 2007, p81–83
  62. ↑ Owen, James (13 May 2004). "Bloodthirsty Bedbugs Stage Comeback in U.S., Europe". National Geographic News. National Geographic. http://news.nationalgeographic.com/news/2004/05/0513_040513_bedbugs.html. Retrieved 31 May 2010. 
  63. ↑ Alvaro, Romero; Potter, Michael F.; Potter, Daniel A.; Haynes, Kenneth F. (2007). "Insecticide Resistance in the Bed Bug: A Factor in the Pest’s Sudden Resurgence". Journal of Medical Entomology 44 (2): 175–178. ISSN 0022-2585. PMID 17427684. http://www.thermal-remediation.com/users/thermal_remediation/files/Insecticide%20Resistance%20in%20the%20Bed%20Bug%20-%20A%20Factor%20in%20the%20Pests%20Sudden%20Resurgence.pdf. Retrieved 1 Jun 2010. 
  64. ↑ Austin, James (2008). "Bed Bugs". Urban and Structural Pests. Center for Urban & Structural Entomology, Department of Entomology, Texas A&M. http://urbanentomology.tamu.edu/bedbugs/bedbugs.cfm. Retrieved 31 May 2010. 
  65. ↑ Steelman, C.D., A.L. Szalanski, R. Trout, J.A. McKern, C. Solorzano, and J.W. Austin. 2008. Susceptibility of the bed bug Cimex lectularius L. (Hemiptera: Cimicidae) to selected insecticides. Journal of Agricultural and Urban Entomology 25: 41-51.
  66. ↑ "Biochemical and Molecular Analysis of Deltamethrin Resistance in the Common Bed Bug (Hemiptera: Cimicidae)" Journal of Medical Entomology, 45 (6), 2008, pp. 1092–1101
  67. ↑ Szalanski, A.L., J.W. Austin, J.A. McKern, C.D. Steelman, and R.E. Gold. 2008. Mitochondrial and ribosomal internal transcribed spacer (ITS1) diversity of the bed bug Cimex lectularius L. (Heteroptera: Cimicidae). Journal of Medical Entomology 45: 229-236.
  68. ↑ Initi, John "Sleeping with the Enemy" Maclean's, 1/14/2008, Vol. 121, Issue 1, p54–56
  69. ↑ Kimberly Stevens (2003-12-25). "Sleeping with the Enemy". New York Times. http://www.nytimes.com/2003/12/25/garden/sleeping-with-the-enemy.html?sec=&spon=&pagewanted=all. Retrieved 2010-01-16. 
  70. ↑ Judge Richard Posner (2003-10-21). "347 F.3d 672 BURL MATHIAS and DESIREE MATHIAS, Plaintiffs-Appellees/Cross-Appellants, v. ACCOR ECONOMY LODGING, INC. and MOTEL 6 OPERATING L.P., Defendants-Appellants/Cross-Appellees. UNITED STATES COURT OF APPEALS FOR THE SEVENTH CIRCUIT Nos. 03-1010, 03-1078". http://www.projectposner.org/case/2003/347F3d672. Retrieved 2010-01-16. 
  71. ↑ Shavell, Steven (2007), "On the Proper Magnitude of Punitive Damages: Mathias v. Accor Economy Lodging, Inc." (PDF), Harvard Law Review 120: 1223–1227, http://www.harvardlawreview.org/issues/120/march07/shavell.pdf, retrieved 2010-01-16 
  72. ↑ Marshall Sella (2010-05-02). "Bedbugs in the Duvet: An infestation on the Upper East Side". New York Magazine. http://nymag.com/news/features/65733/. Retrieved 2010-06-11. 
  73. ↑ Megan Gibson (2010-08-19). "Are Bedbugs Taking Over New York City?". Time Magazine. http://newsfeed.time.com/2010/08/19/are-bedbugs-taking-over-new-york-city/. 
  74. ↑ Potter, Michael F.. "BED BUGS". University of Kentucy College of Agriculture. http://www.ca.uky.edu/entomology/entfacts/ef636.asp. Retrieved 27 June2010. 
  75. ↑ Waldvogel, M., C Apperson. 2006 " Bed Bugs." http://www.ces.ncsu.edu/depts/ent/notes/Urban/bedbugs.htm 21 November 2008
  76. ↑ Pfiester, Margie; Koehler, Philip G.; Pereira, Roberto M. (Aug 2008). "Ability of Bed Bug-Detecting Canines to Locate Live Bed Bugs and Viable Bed Bug Eggs". Entomological Society of America. http://www.bioone.org/doi/abs/10.1603/0022-0493%282008%29101%5B1389%3AAOBBCT%5D2.0.CO%3B2?journalCode=ecen#FN1. Retrieved 26 Aug 2010. 
  77. ↑ Juliano, Michael C., "Dogs don't let the bed bugs bite", The Advocate of Stamford, Connecticut, p 1, August 21, 2009

Further reading

External links

Generic information

Health and control aspects

Psychophysiology: Sleep and sleep disorders (F51 and G47, 307.4 and 327)
Sleep stages
Rapid eye movement sleep · Non-rapid eye movement sleep · Slow-wave sleep
Brain waves
Alpha wave · Beta wave · Gamma wave · Delta wave · Theta rhythm · K-complex
Sleep
disorders
Dyssomnia
Insomnia · Narcolepsy · Sleep apnea (Obesity hypoventilation syndrome, Ondine's curse) · Hypersomnia · Kleine-Levin syndrome · Sleep state misperception
Circadian rhythm
sleep disorder
Advanced sleep phase syndrome · Delayed sleep phase syndrome · Non-24-hour sleep-wake syndrome · Jet lag
Parasomnia
Night terror · Sleepwalking · Somniloquy
Other/ungrouped
Night eating syndrome · Nocturia · Nocturnal myoclonus ·
Benign
phenomena
Dream · Exploding head syndrome · False awakening · Hypnagogia · Hypnic jerk · Lucid dream · Nightmare · Nocturnal emission · Nocturnal penile tumescence · Sleep paralysis · Somnolence
Related
topics
Bed (Bunk bed, Four poster bed, Futon, Daybed, Hammock, Mattress, Sleeping bag) · Bed bug · Bedding · Bedroom · Bedtime · Bedtime toy · Bedtime story · Caffeine nap · Chronotype · Dream journal · Hypnopompic state · Lullaby · Methods of falling asleep · Microsleep · Nap · Nightwear · Polyphasic sleep · Polysomnography · Power nap · Second wind · Siesta · Sleep and creativity · Sleep and learning · Sleep debt · Sleep deprivation · Sleep diary · Sleep inertia · Sleep medicine · Sleeping while on duty · Sleepover · Snoring · Excessive daytime sleepiness · ("Sleeping sickness", which is not a sleep disorder.)

: PSO/PSI

mepr

dsrd (o, p, m, p, a, d, s), sysi/, spvo

, drug(N5A/5B/5C/6A/6B/)

: CNS

anat(s,m,p,,e,b,d,c,,f,,g)/phys/devp/cell

noco(m,d,e,h,v,s)/cong/tumr,sysi/,injr

proc,drug(N1A/2AB/C/3/4/7A/B//)
Infectious diseases - Parasitic disease: ectoparasitic infestation / arthropod (B85-B89, 132-134)
Insecta

Pediculus humanus corporis/Pediculus humanus capitis (Pediculosis, Head-louse infestation, Pediculosis corporis)

Phthirus pubis (Phthiriasis)
Cimex (Cimicosis)
Dermatobia hominis/Cordylobia anthropophaga (Myiasis)
Tunga penetrans (Tungiasis)
Arachnida
Acariasis/mange (mites)

Trombidiformes: Trombicula (Trombiculosis, Chigger bite) · Demodex brevis/Demodex folliculorum (Demodicosis, Demodex mite bite) · Pyemotes herfsi · Cheyletiella (Cheyletiellosis)

Sarcoptiformes: Sarcoptes scabiei (Scabies)

Parasitiformes: Dermanyssus gallinae · Liponyssoides sanguineus
Tick infestation
Crustacea
Pentastomida
Linguatula serrata (Linguatulosis) · Porocephalus crotali/Armillifer armillatus (Porocephaliasis)

: IFT

helm,arth (acar)

helm, arth (lice), zoon

, arth