Mental disorder

Mental disorder
Classification and external resources
MeSH D001523

A mental disorder or mental illness is a psychological or behavioral pattern that occurs in an individual and is thought to cause distress or disability that is not expected as part of normal development or culture. The recognition and understanding of mental disorders have changed over time and across cultures. Definitions, assessments, and classifications of mental disorders can vary, but guideline criteria listed in the ICD, DSM and other manuals are widely accepted by mental health professionals. Categories of diagnoses in these schemes may include dissociative disorders, mood disorders, anxiety disorders, psychotic disorders, eating disorders, developmental disorders, personality disorders, and many other categories. In many cases there is no single accepted or consistent cause of mental disorders, although they are often explained in terms of a diathesis-stress model and biopsychosocial model. Mental disorders have been found to be common, with over a third of people in most countries reporting sufficient criteria at some point in their life. Services for mental disorders may be based in hospitals or in the community. Mental health professionals diagnose individuals using different methodologies, often relying on case history and interview. Psychotherapy and psychiatric medication are two major treatment options, as well as supportive interventions and self-help. Treatment may be involuntary where legislation allows. Several movements campaign for changes to services and attitudes, including the Consumer/Survivor Movement. There are widespread problems with stigma and discrimination.

Contents

Classification

Main article: Classification of mental disorders

The definition and classification of mental disorder is a key issue for the mental health professions and for users and providers of mental health services. Most international clinical documents use the term "mental disorder" rather than "mental illness". There is no single definition and the inclusion criteria are said to vary depending on the social, legal and political context. In general, however, a mental disorder has been characterized as a clinically significant behavioral or psychological pattern that occurs in an individual and is usually associated with distress, disability or increased risk of suffering. The term "serious mental illness" (SMI) is sometimes used to refer to more severe and long-lasting disorder. A broad definition can cover mental disorder, mental retardation, personality disorder and substance dependence. The phrase "mental health problems" may be used to refer only to milder or more transient issues. There is often a criterion that a condition should not be expected to occur as part of a person's usual culture or religion. Nevertheless, the term "mental" is not necessarily used to imply a distinction between mental (dys)functioning and brain (dys)functioning, or indeed between the brain and the rest of the body.

There are currently two widely established systems that classify mental disorders - Chapter V of the International Classification of Diseases (ICD-10), produced by the World Health Organization (WHO), and the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) produced by the American Psychiatric Association (APA). Both list categories of disorder and provide standardized criteria for diagnosis. They have deliberately converged their codes in recent revisions so that the manuals are often broadly comparable, although significant differences remain. Other classification schemes may be in use more locally, for example the Chinese Classification of Mental Disorders. Other manuals may be used by those of alternative theoretical persuasions, for example the Psychodynamic Diagnostic Manual.

Some approaches to classification do not employ distinct categories based on cut-offs separating the abnormal from the normal. They are variously referred to as spectrum, continuum or dimensional systems. There is a significant scientific debate about the relative merits of a categorical or a non-categorical system. There is also significant controversy about the role of science and values in classification schemes, and about the professional, legal and social uses to which they are put.

Disorders

There are many different categories of mental disorder, and many different facets of human behavior and personality that can become disordered.[1][2][3][4]

The state of anxiety or fear can become disordered, so that it is unusually intense or generalized over a prolonged period of time. Commonly recognized categories of anxiety disorders include specific phobia, Generalized anxiety disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Obsessive-Compulsive Disorder, Post-traumatic stress disorder. Relatively long lasting affective states can also become disordered. Mood disorder involving unusually intense and sustained sadness, melancholia or despair is know as Clinical depression (or Major depression), and may more generally be described as Emotional dysregulation. Milder but prolonged depression can be diagnosed as dysthymia. Bipolar disorder involves abnormally "high" or pressured mood states, known as mania or hypomania, alternating with normal or depressed mood. Whether unipolar and bipolar mood phenomena represent distinct categories of disorder, or whether they usually mix and merge together along a dimension or spectrum of mood, is under debate in the scientific literature.[5]

Patterns of belief, language use and perception can become disordered. Psychotic disorders centrally involving this domain include Schizophrenia and Delusional disorder. Schizoaffective disorder is a category used for individuals showing aspects of both schizophrenia and affective disorders. Schizotypy is a category used for individuals showing some of the traits associated with schizophrenia but without meeting cut-off criteria.

The fundamental characteristics of a person that influence his or her cognitions, motivations, and behaviors across situations and time - can be seen as disordered due to being abnormally rigid and maladaptive. Categorical schemes list a number of different personality disorders, such as those classed as eccentric (e.g. Paranoid personality disorder, Schizoid personality disorder, Schizotypal personality disorder), those described as dramatic or emotional (Antisocial personality disorder, Borderline personality disorder, Histrionic personality disorder, Narcissistic personality disorder) or those seen as fear-related (Avoidant personality disorder, Dependent personality disorder, Obsessive-compulsive personality disorder).

There may be an emerging consensus that personality disorders, like personality traits in the normal range, incorporate a mixture of more acute dysfunctional behaviors that resolve in relatively short periods, and maladaptive temperamental traits that are relatively more stable.[6] Non-categorical schemes may rate individuals via a profile across different dimensions of personality that are not seen as cut off from normal personality variation, commonly through schemes based on the Big Five personality traits.[7]

Other disorders may involve other attributes of human functioning. Eating practices can be disordered, at least in relatively rich industrialized areas, with either compulsive over-eating or under-eating or binging. Categories of disorder in this area include Anorexia nervosa, Bulimia nervosa, Exercise Bulimia or Binge eating disorder. Sleep disorders such as Insomnia also exist and can disrupt normal sleep patterns. Sexual and gender identity disorders, such as Dyspareunia or Gender identity disorder or ego-dystonic homosexuality. People who are abnormally unable to resist urges, or impulses, to perform acts that could be harmful to themselves or others, may be classed as having an impulse control disorder, including various kinds of Tic disorders such as Tourette's Syndrome, and disorders such as Kleptomania (stealing) or Pyromania (fire-setting). Substance-use disorders include Substance abuse disorder. Addictive gambling may be classed as a disorder. Inability to sufficiently adjust to life circumstances may be classed as an Adjustment disorder. The category of adjustment disorder is usually reserved for problems beginning within three months of the event or situation and ending within six months after the stressor stops or is eliminated. People who suffer severe disturbances of their self-identity, memory and general awareness of themselves and their surroundings may be classed as having a Dissociative identity disorder, such as Depersonalization disorder or Dissociative Identify Disorder itself (which has also been called multiple personality disorder, or "split personality".). Factitious disorders, such as Munchausen syndrome, also exist where symptoms are experienced and/or reported for personal gain.

Disorders appearing to originate in the body, but thought to be mental, are known as somatoform disorders, including Somatization disorder. There are also disorders of the perception of the body, including Body dysmorphic disorder. Neurasthenia is a category involving somatic complaints as well as fatigue and low spirits/depression, which is officially recognized by the ICD-10 but not by the DSM-IV.[8] Memory or cognitive disorders, such as amnesia or Alzheimer's disease exist.

Some disorders are thought to usually first occur in the context of early childhood development, although they may continue into adulthood. The category of Specific developmental disorder may be used to refer to circumscribed patterns of disorder in particular learning skills, motor skills, or communication skills. Disorders which appear more generalized may be classed as pervasive developmental disorders (PDD) also known as autism spectrum disorders (ASD); these include autism, Asperger's, Rett syndrome, childhood disintegrative disorder and other types of PDD whose exact diagnosis may not be specified. Other disorders mainly or first occurring in childhood include Reactive attachment disorder; Separation Anxiety Disorder; Oppositional Defiant Disorder; Attention Deficit Hyperactivity Disorder.

Other proposed disorders include: Self-defeating personality disorder, Sadistic personality disorder, Passive-aggressive personality disorder, Premenstrual dysphoric disorder, Video game addiction or Internet addiction disorder.

Causes

Main article: Causes of mental disorders

Numerous factors have been linked to the development of mental disorders. In many cases there is no single accepted or consistent cause currently established. A common view held is that disorders often result from genetic vulnerabilities combining with environmental stressors (Diathesis-stress model). An eclectic or pluralistic mix of models may be used to explain particular disorders. The primary paradigm of contemporary mainstream Western psychiatry is said to be the biopsychosocial (BPS) model - incorporating biological, psychological and social factors - although this may not be applied in practice. Biopsychiatry has tended to follow a biomedical model, focusing on "organic" or "hardware" pathology of the brain. Psychoanalytic theories have been popular but are now less so. Evolutionary psychology may be used as an overall explanatory theory. Attachment theory is another kind of evolutionary-psychological approach sometimes applied in the context for mental disorders. A distinction is sometimes made between a "medical model" or a "social model" of disorder and related disability.

Genetic studies have indicated that genes often play an important role in the development of mental disorders, via developmental pathways interacting with environmental factors. The reliable identification of connections between specific genes and specific categories of disorder has proven more difficult.

Environmental events surrounding pregnancy and birth have also been implicated. Traumatic brain injury may increase the risk of developing certain mental disorders. There have been some tentative inconsistent links found to certain viral infections, to substance misuse, and to general physical health.

Abnormal functioning of neurotransmitter systems has been implicated, including serotonin, norepinephrine, dopamine and glutamate systems. Differences have also been found in the size or activity of certain brains regions in some cases. Psychological mechanisms have also been implicated, such as cognitive and emotional processes, personality, temperament and coping style.

Social influences have been found to be important, including abuse, bullying and other negative or stressful life experiences. The specific risks and pathways to particular disorders are less clear, however. Aspects of the wider community have also been implicated, including employment problems, socioeconomic inequality, lack of social cohesion, problems linked to migration, and features of particular societies and cultures.

Culture

Mental disorders are often distinguished from experiences or behaviors said to be expected or "normal" within a culture. Criteria and concepts employed to achieve this, for example "incomprehensibility" or "bizarre", are ubiquitous but "infested" with ambiguity and subjectivity, especially across cultures.[9] The issue is particularly contentious with regard to religious, spiritual or transpersonal experiences and beliefs, especially given the diversity involved across cultures, and are often not defined as disordered especially if widely shared, despite the fact that many could easily be seen as delusional from a "rational" point of view.[10][11] There is also a more general overlap and ambiguity between clinical concepts and the realm of morality, and it has been argued that attempts to separate them cannot do so without altering the essence of what it means to be a particular person in society.[12]

Cultural processes can affect which behaviors are considered clinically relevant and how they are framed. The DSM has been said to have a Euro-American outlook, such that differing disorders or concepts from other countries or non-mainstream cultures are neglected or misrepresented; while the latter are described as "culture-bound syndromes", Western cultural phenomena are taken as universals.[13][14] The fact that diagnostic criteria sets are acceptable to or applied reliably across different cultures does not necessarily make the constructs themselves valid within those cultures, as this can be statistically achieved through an entirely illusory diagnostic construct. On the other hand, it is argued that if a diagnostic category is valid then cross-cultural factors are irrelevant, or only affect how symptoms are manifested.[15]

Cultural variation can suggest that the very construct of "mental disorder" is in fact culture-bound. Different societies, cultures, and even persons within a particular culture may disagree as to what constitutes optimal or pathological biological and psychological functioning, and indeed research has demonstrated variation across cultures in the relative importance placed on, for example, happiness, autonomy, or social relationships for pleasure. Likewise, the fact that a behavior pattern is valued, accepted, encouraged, or even statistically normative within a particular culture does not necessarily mean it is conducive to optimal psychological functioning. There may be a tendency to overstate or misinterpret neurophysiological findings and to understate the scientific importance of social-psychological variables,[15] and the cultural and ethnic diversity of individuals is often discounted by researchers and services providers.[16] Rather than indicating a disorder from within, distress and disability may be seen as an indicator of emotional struggle and the need to address social and structural problems[17][18] and some academics and clinicians have advocated a postmodernist conceptualization of mental distress and wellbeing[19][20] and "heretical" psychologies centered on alternative cultural and ethnic identities and experiences.[21]

Diagnosis

Many mental health professionals, particularly psychiatrists, seek to diagnose individuals by ascertaining their particular mental disorder. Some professionals, for example some clinical psychologists, may avoid diagnosis in favor of other assessment methods such as formulation of a client's difficulties and circumstances.[22] The majority of mental health problems are actually assessed and treated by family physicians during consultations, who may refer on for more specialist diagnosis in acute or chronic cases. Routine diagnostic practice in mental health services typically involves an interview (which may be referred to as a mental status examination), where judgments are made of the interviewee's appearance and behavior, self-reported symptoms, mental health history, and current life circumstances. The views of relatives or other third parties may be taken into account. A physical examination to check for ill health or the effects of medications or other drugs may be conducted. Psychological testing is sometimes used via paper-and-pen or computerized questionnaires, which may include algorithms based on ticking off standardized diagnostic criteria, and in relatively rare specialist cases neuroimaging tests may be requested, but these methods are more commonly found in research studies than routine clinical practice.[23][24] Time and budgetary constraints often limit practicing psychiatrists from conducting more thorough diagnostic evaluations.[25] It has been found that most clinicians evaluate patients using an unstructured, open-ended approach, with limited training in evidence-based assessment methods, and that inaccurate diagnosis may be common in routine practice.[26] Mental illness involving hallucinations or delusions (especially schizophrenia) are prone to misdiagnosis in developing countries due to the presence of psychotic symptoms instigated by nutritional deficiencies. Comorbidity is very common in psychiatric diagnosis, i.e. the same person given a diagnosis in more than one category of disorder.

Services and treatments

Main article: Treatment of mental disorders
Main article: Services for mental disorders

Treatment and support may be provided in psychiatric hospitals, clinics or any of a diverse range of community mental health services. Often an individual may engage in different treatment modalities. A strong sense of being part of an interdependent society in developing countries makes the community-based treatment model the most effective mode of treatment. A combination of community-based treatment and the use of typical antipsychotic drugs have been found to yield the most positive, cost-effective results. Individuals may be treated against their will in some cases. Services in some countries are increasingly based on a Recovery model that supports an individual's personal journey to regain a meaningful life.

Psychotherapy

A major option for many mental disorders is psychotherapy. There are several main types. Cognitive behavioral therapy (CBT) is widely used and is based on modifying the patterns of thought and behavior associated with a particular disorder. Psychoanalysis, addressing underlying psychic conflicts and defenses, has been a dominant school of psychotherapy and is still in use. Systemic therapy or family therapy is sometimes used, addressing a network of significant others as well as an individual. Some psychotherapies are based on a humanistic approach. There are a number of specific therapies used for particular disorders, which may be offshoots or hybrids of the above types. Mental health professionals often employ an eclectic or integrative approach. Much may depend on the therapeutic relationship, and there may be problems with trust, confidentiality and engagement.

Medication

A major option for many mental disorders is psychiatric medication. There are several main groups. Antidepressants are used for the treatment of clinical depression as well as often for anxiety and other disorders. There are a number of antidepressants beginning with the tricyclics, moving through a wide variety of drugs that modify various facets of the brain chemistry dealing with intercellular communication. Beta-blockers, developed as a heart medication, is also used as an antidepressant. Anxiolytics are used for anxiety disorders and related problems such as insomnia. Mood stabilizers are used primarily in bipolar disorder. Lithium A (a metal) and Lamictal (an epileptic drug) are notable for treating both mania and depression. The others, mainly targeting mania rather than depression, are a wide variety of epilepsy medications and antipsychotics. Antipsychotics are used for psychotic disorders, notably for positive symptoms in schizophrenia. Although there has not been any evidence of the superiority of newer, atypical antipsychotic drugs, they are being prescribed to individuals in impoverished areas who may not be able to afford them. The prescription of relatively cheaper, older typical antipsychotic drugs is the most desired method. Stimulants are commonly used, notably for ADHD. Despite the different conventional names of the drug groups, there can be considerable overlap in the kinds of disorders for which they are actually indicated. There may also be off-label use. There can be problems with adverse effects and adherence.

Other

Electroconvulsive therapy (ECT) is sometimes used in severe cases when other interventions for severe intractable depression have failed. Psychosurgery is considered experimental but is advocated by certain neurologists in certain rare cases.[27][28]

Psychoeducation may be used to provide people with the information to understand and manage their problems. Creative therapies are sometimes used, including music therapy, art therapy or drama therapy. Lifestyle adjustments and supportive measures are often used, including peer support, self-help groups for mental health and supported housing or supported employment (including social firms). Some advocate dietary supplements.[29] Many things have been found to help at least some people. A placebo effect may play a role in any intervention.

Prognosis

Prognosis depends on the disorder, the individual and numerous related factors. Some disorders may be transient, while some may last a lifetime in some cases. Some disorders may be very limited in their functional effects, while others may involve substantial disability and support needs. The degree of ability or disability may vary across different life domains. Continued disability has been linked to institutionalization, discrimination and social exclusion as well as to the inherent properties of disorders.

Even those disorders often considered the most serious and intractable have varied courses. Long-term international studies of schizophrenia have found that over a half of individuals recover in terms of symptoms, and around a fifth to a third in terms of symptoms and functioning, with some requiring no medication. At the same time, many have serious difficulties and support needs for many years, although "late" recovery is still possible. The WHO concluded that the findings joined others in "relieving patients, carers and clinicians of the chronicity paradigm which dominated thinking throughout much of the 20th century."[30][31] Around half of people initially diagnosed with bipolar disorder achieve syndromal recovery (no longer meeting criteria for the diagnosis) within six weeks, and nearly all achieve it within two years, with nearly a half regaining their prior occupational and residential status in that period. However, nearly a half go on to experience a new episode of mania or major depression within the next two years.[32] Functioning has been found to vary, being poor during periods of major depression or mania but otherwise fair to good, and possibly superior during periods of hypomania in Bipolar II.[33]

Despite often being characterized in purely negative terms, some mental states labeled as disorders can also involve above-average creativity, non-conformity, goal-striving, meticulousness, or empathy.[34] In addition, the public perception of the level of disability associated with mental disorders can change.[35]

Prevalence

Main article: Prevalence of mental disorders

Mental disorders have been found to be relatively common, with more than one in three people in most countries reporting sufficient criteria for at least one diagnosis at some point in their life up to the time they were assessed.[36] A new WHO global survey currently underway[1] indicates that anxiety disorders are the most common in all but 1 country, followed by mood disorders in all but 2 countries, while substance disorders and impulse-control disorders were consistently less prevalent. Rates varied by region.[37] Such statistics are widely believed to be underestimates, due to poor diagnosis (especially in countries without affordable access to mental health services) and low reporting rates, in part because of the predominant use of self-report data rather than semi-structured instruments. Actual lifetime prevalence rates for mental disorders are estimated to be between 65% and 85%.

A review of anxiety disorder surveys in different countries found average lifetime prevalence estimates of 16.6%, with women having higher rates on average.[38] A review of mood disorder surveys in different countries found lifetime rates of 6.7% for major depressive disorder (higher in some studies, and in women) and 0.8% for bipolar 1 disorder.[39]

The updated US National Comorbidity Survey (NCS) reported that nearly half of Americans (46.4%) meet criteria at some point in their life for either an anxiety disorder (28.8%), mood disorder (20.8%), impulse-control disorder (24.8%) or substance use disorder (14.6%).[40][41][42]

A 2004 cross-Europe study found that approximately one in four people reported meeting criteria at some point in their life for at least one of the DSM-IV disorders assessed, which included mood disorders (13.9%), anxiety disorders (13.6%) or alcohol disorder (5.2%). Approximately one in ten met criteria within a 12-month period. Women and younger people of either gender showed more cases of disorder.[43] A 2005 review of surveys in 16 European countries found that 27% of adult Europeans are affected by at least one mental disorder in a 12 month period.[44]

An international review of studies on the prevalence of schizophrenia found an average (median) figure of 0.4% for lifetime prevalence; it was consistently lower in poorer countries.[45]

Studies of the prevalence of personality disorders (PDs) have been fewer and smaller-scale, but one broad Norwegian survey found a five-year prevalence of almost 1 in 7 (13.4%). Rates for specific disorders ranged from 0.8% to 2.8%, differing across countries, and by gender, educational level and other factors.[46] A US survey that incidentally screened for personality disorder found a rate of 14.79%.[47]

Approximately 7% of a preschool pediatric sample were given a psychiatric diagnosis in one clinical study, and approximately 10% of 1- and 2-year-olds receiving developmental screening have been assessed as having significant emotional/behavioral problems based on parent and pediatrician reports.[48]

History

Eight women representing prominent mental diagnoses in the nineteenth century.
Main article: History of mental disorders

Ancient civilisations described and treated a number of mental disorders. The Greeks coined terms for melancholy, hysteria and phobia and developed humorism theory. Psychiatric theories and treatments developed in Persia, Arabia and the Muslim Empire, particularly in the medieval Islamic world from the 8th century, where the first psychiatric hospitals were built. Conceptions of madness in the Middle Ages in Christian Europe were a mixture of the divine, diabolical, magical and humoral, as well as more down to earth considerations. In the early modern period, some people with mental disorders may have been victims of the witch-hunts but were increasingly admitted to local workhouses and jails or sometimes to private madhouses. Many terms for mental disorder that found their way into everyday use first became popular the 16th and 17th centuries. By the end of the 17th century and into the enlightenment, madness was increasingly seen as an organic physical phenomenon with no connection to the soul or moral responsibility. Asylum care was often harsh and treated people like wild animals, but towards the end of the 18th century a moral treatment movement gradually developed. Clear descriptions of some syndromes may be relatively rare prior to the 1800s. Industrialization and population growth led to a massive expansion of the number and size of insane asylums in every Western country in the 19th century. Numerous different classification schemes and diagnostic terms were developed by different authorities, and the term psychiatry was coined, though medical superintendents were still known as alienists.

The turn of the 20th century saw the development of psychoanalysis, which would later come to the fore, along with Kraepelin's classification scheme. Asylum "inmates" were increasingly referred to as "patients" and asylums renamed as hospitals. In the United States, a mental hygiene movement aimed to prevent mental disorders. Clinical psychology and social work developed as professions. World War I saw a massive increase of conditions that came to be termed "shell shock." World War II saw the development in the U.S. of a new psychiatric manual for categorizing mental disorders, which along with existing systems for collecting census and hospital statistics led to the first Diagnostic and Statistical Manual of Mental Disorders (DSM). The International Classification of Diseases (ICD) followed suit with a section on mental disorders. The term stress, having emerged out of endocrinology work in the 1930s, was increasingly applied to mental disorders. Electroconvulsive therapy, insulin shock therapy, lobotomies and the "neuroleptic" chlorpromazine came to be used by mid-century. An antipsychiatry movement came to the fore in the 1960s. Deinstitutionalization gradually occurred in the West, with isolated psychiatric hospitals being closed down in favor of community mental health services. A consumer/survivor movement gained momentum. Other kinds of psychiatric medication gradually came into use, such as "psychic energizers" and lithium. Benzodiazepines gained widespread use in the 1970s for anxiety and depression, until dependency problems curtailed their popularity. Advances in neuroscience and genetics led to new research agendas. Cognitive behavioral therapy was developed. The DSM and then ICD adopted new criteria-based classifications, and the number of "official" diagnoses saw a large expansion. Through the 1990s, new SSRI antidepressants became some of the most widely prescribed drugs in the world. A recovery model developed.

Professions and fields

Main article: Mental health professional

A number of professions have developed that specialise in the treatment of mental disorders, including the medical speciality of psychiatry (including psychiatric nursing),[49][50][51] the division of psychology known as clinical psychology,[52] Social Work,[53] as well as Mental Health Counselors, Marriage and Family Therapists, Psychotherapists, Counselors and Public Health professionals. Those with personal experience of using mental health services are also increasingly involved in researching and delivering mental health services and working as mental health professionals.[54][55][56][57] The different clinical and scientific perspectives draw on diverse fields of research and theory, and different disciplines may favor differing models, explanations and goals.[34]

Movements

The Consumer/Survivor Movement (also known as user/survivor movement) is made up of individuals (and organizations representing them) who are clients of mental health services or who consider themselves "survivors" of mental health services. The movement campaigns for improved mental health services and for more involvement and empowerment within mental health services, policies and wider society.[58][59][60] Patient advocacy organizations have expanded with increasing deinstitutionalization in developed countries, working to challenge the stereotypes, stigma and exclusion associated with psychiatric conditions. An antipsychiatry movement fundamentally challenges mainstream psychiatric theory and practice, including the reality or utility of psychiatric diagnoses of mental illnesses.[61][62] [63]

Laws and policies

Three quarters of countries around the world have mental health legislation. Compulsory admission to mental health facilities (also known as Involuntary commitment or sectioning), is a controversial topic. From some points of view it can impinge on personal liberty and the right to choose, and carry the risk of abuse for political, social and other reasons; from other points of view, it can potentially prevent harm to self and others, and assist some people in attaining their right to healthcare when unable to decide in their own interests.[64]

All human-rights oriented mental health laws require proof of the presence of a mental disorder as defined by internationally accepted standards, but the type and severity of disorder that counts can vary in different jurisdictions. The two most often utilized grounds for involuntary admission are said to be serious likelihood of immediate or imminent danger to self or others, and the need for treatment. Applications for someone to be involuntarily admitted may usually come from a mental health practitioner, a family member, a close relative, or a guardian. Human-rights-oriented laws usually stipulate that independent medical practitioners or other accredited mental health practitioners must examine the patient separately and that there should be regular, time-bound review by an independent review body.[64] An individual must be shown to lack the capacity to give or withhold informed consent (i.e. to understand treatment information and its implications). Legal challenges in some areas have resulted in supreme court decisions that a person does NOT have to agree with a psychiatrist's characterization of their issues as an "illness", nor with a psychiatrist's conviction in medication, but only recognise the issues and the information about treatment options.[65]

Proxy consent (also known as substituted decision-making) may be given to a personal representative, a family member or a legally appointed guardian, or patients may have been able to enact an advance directive as to how they wish to be treated.[64] The right to supported decision-making may also be included in legislation.[66] Involuntary treatment laws are increasingly extended to those living in the community, for example outpatient commitment laws (known by different names) are used in New Zealand, Australia, United Kingdom and most of the United States.

The World Health Organization reports that in many instances national mental health legislation takes away the rights of persons with mental disorders rather than protecting rights, and is often outdated.[64] In 1991, the United Nations adopted the Principles for the Protection of Persons with Mental Illness and the Improvement of Mental Health Care, which established minimum human rights standards of practice in the mental health field. In 2006 the UN formally agreed the Convention on the Rights of Persons with Disabilities to protect and enhance the rights and opportunities of disabled people, including those with psychosocial disabilities[67]

The term insanity, sometimes used colloquially as a synonym for mental illness, is often used technically as a legal term.

Perception and discrimination

Stigma

The social stigma associated with mental disorders is a widespread problem. Some people believe those with serious mental illnesses cannot recover, or are to blame for problems.[68] The US Surgeon General stated in 1999 that: "Powerful and pervasive, stigma prevents people from acknowledging their own mental health problems, much less disclosing them to others.[69] Employment discrimination is reported to play a significant part in the high rate of unemployment among those with a diagnosis of mental illness.[70]

Efforts are being undertaken worldwide to eliminate the stigma of mental illness[71] Their methods and outcomes have sometimes been criticized as counterproductive.[72]

A study by Baylor University researchers found that clergy often deny or dismiss the existence of the mental illness. In a study published in Mental Health, Religion and Culture, researchers found that in a study of 293 Christians church members, more than 32 percent were told by their church pastor that they or their loved one did not really have a mental illness. The study found these church members were told the cause of their problem was solely spiritual in nature, such as a personal sin, lack of faith or demonic involvement. Baylor researchers also found that women were more likely than men to have their mental disorders dismissed by the church. All of the participants in both studies were previously diagnosed by a licensed mental health provider as having a serious mental illness, like bipolar disorder and schizophrenia, prior to approaching their local church for assistance.[73]

Media and general public

Main article: Mental disorders in art and literature

Media coverage of mental illness comprises predominantly negative depictions, for example, of incompetence, violence or criminality, with far less coverage of positive issues such as accomplishments or human rights issues.[74][75][76] Such negative depictions, including in children's cartoons, are thought to contribute to stigma and negative attitudes in the public and in those with mental health problems themselves, although more sensitive or serious cinematic portrayals have increased in prevalence.[77][78]

In the United States, The Carter Center has created fellowships for journalists in South Africa, the U.S., and Romania, to enable reporters to research and write stories on mental health topics.[79] Former U.S. First Lady Rosalynn Carter began the fellowships not only to train reporters in how to sensitively and accurately discuss mental health and mental illness, but also to increase the number of stories on these topics in the news media.[80] [81]

The general public have been found to hold a strong stereotype of dangerousness and desire for social distance from individuals described as mentally ill.[82]

Violence

People with mental disorders are often afraid of violence against them. Over a quarter of individuals diagnosed with "severe mental illness" accessing community mental health services in a US inner-city area were found to have been victims of at least one violent crime in a year, a proportion eleven times higher than the inner-city average. The proportion is many times greater in every category of crime, including rape/sexual assault, other violent assaults, and personal and property theft.[83][84] Findings consistently indicate that it is many times more likely that people diagnosed with a serious mental illness living in the community will be the victims rather than the perpetrators of violence.[85][86]

However, fear of unpredictable violent acts by people with mental illness is also common. One US national survey indicated that a far higher percentage of Americans rated individuals described as displaying the characteristics of a mental disorder (for example Schizophrenia or Substance Use Disorder) as "likely to do something violent to others" compared to those described as being 'troubled'.[87] Research indicates, on balance, a higher than average number of violent acts by some individuals with certain diagnoses, notably antisocial or psychopathic personality disorders, but conflicting findings about specific symptoms (for example links between psychosis and violence in community settings) - but the mediating factors of such acts are most consistently found to be mainly socio-demographic and socio-economic factors such as being young, male, of lower socio-economic status and, in particular, substance abuse (including alcohol).[85][88][34] For the most serious crimes, such as homicide, some diagnoses are over-represented in arrests/convictions; however, although high-profile cases have lead to fears that this has increased due to deinstitutionalization, this does not reflect the evidence.[89]

Violence related to mental disorder (in either direction) typically occurs in the context of complex social interactions, often in a family setting rather than between strangers.[90] It is also an issue in health care settings[91] and the wider community.[92]

Non-human

Psychopathology in non-human primates has been studied since the mid 20th century. Over 20 behavioral patterns in captive chimpanzees have been documented as (statistically) abnormal for their frequency, severity or oddness - some of which have also been observed in the wild. Captive great apes show gross behavioral abnormalities such as stereotypy of movements, self-mutilation, disturbed emotional reactions (mainly fear or aggression) towards companions, lack of species-typical communications, and generalized learned helplessness. In some cases such behaviors are hypothesized to be equivalent to symptoms associated with psychiatric disorders in humans such as depression, anxiety disorders, eating disorders and post-traumatic stress disorder. Concepts of antisocial, borderline and schizoid personality disorders have also been applied to non-human great apes.[93]

The risk of anthropomorphism is often raised with regard to such comparisons, and assessment of non-human animals cannot incorporate evidence from linguistic communication. However, available evidence may range from nonverbal behaviors - including physiological responses and homologous facial displays and acoustic utterances - to neurochemical studies. It is pointed out that human psychiatric classification is often based on statistical description and judgement of behaviors (especially when speech or language is impaired) and that the use of verbal self-report is itself problematic and unreliable.[93][94]

Psychopathology has generally been traced, at least in captivity, to adverse rearing conditions such as early separation of infants from mothers; early sensory deprivation; and extended periods of social isolation. Studies have also indicated individual variation in temperament, such as sociability or impulsiveness. Particular causes of problems in captivity have included integration of strangers in to existing groups and a lack of individual space, in which context some pathological behaviors have also been seen as coping mechanisms. Remedial interventions have included careful individually-tailored re-socialization programs, behavior therapy, environment enrichment, and on rare occasions psychiatric drugs. Socialization has been found to work 90% of the time in disturbed chimpanzees, although restoration of functional sexuality and care-giving is often not achieved.[93][95]

Laboratory researchers sometimes try to induce symptoms in animals through genetic, neurological or behavioral manipulation,[96][97] although this has been criticized on empirical grounds and opposed on animal rights grounds. The modern city, in connection with the psychological disorders of its residents, has been described as a human zoo.

See also

  • Allan Memorial Institute
  • Anti-psychiatry
  • Douglas Hospital
  • DSM-IV Codes
  • List of mentally ill monarchs
  • Mental disorder defence
  • Mental disorders and gender

Notes

  1. Gazzaniga, M.S., & Heatherton, T.F. (2006). Psychological Science. New York: W.W. Norton & Company, Inc.
  2. WebMD, Inc. (2005, July 01). Mental Health: Types of Mental Illness. Retrieved April 19, 2007, from http://www.webmd.com/mental-health/mental-health-types-illness
  3. United States Department of Health & Human Services. (1999). Overview of Mental Illness. Retrieved April 19, 2007
  4. NIMH (2005) Teacher's Guide: Information about Mental Illness and the Brain Curriculum supplement from The NIH Curriculum Supplements Series
  5. Akiskal, HS. & Benazzi, F. (2006) The DSM-IV and ICD-10 categories of recurrent (major) depressive and bipolar II disorders: evidence that they lie on a dimensional spectrum. Journal of Affective Disorders May;92(1):45-54.
  6. Lee Anna Clark (2007) Assessment and Diagnosis of Personality Disorder: Perennial Issues and an Emerging Reconceptualization Annual Review of Psychology Vol. 58: 227-257
  7. Morey LC, Hopwood CJ, Gunderson JG, Skodol AE, Shea MT, Yen S, Stout RL, Zanarini MC, Grilo CM, Sanislow CA, McGlashan TH. (2006) Comparison of alternative models for personality disorders. Psychol Med. Nov 23;:1-12
  8. Gamma A, Angst J, Ajdacic V, Eich D, Rossler W. (2007) The spectra of neurasthenia and depression: course, stability and transitions. Eur Arch Psychiatry Clin Neurosci. Mar;257(2):120-7.
  9. Markus Heinimaa (2002) Incomprehensibility: The role of the concept in DSM-IV definition of schizophrenic delusions Medicine, Health Care and Philosophy volume 5, Number 3/ October, p291-295 DOI 10.1023/A:1021164602485
  10. Pierre, J. (2001) Faith or Delusion? At the Crossroads of Religion and Psychosis Journal of Psychiatric Practice. 7(3):163-172, May 2001.
  11. Chad V. Johnson* and Harris L. Friedman (2008) Enlightened or Delusional? Differentiating Religious, Spiritual, and Transpersonal Experiences from Psychopathology Journal of Humanistic Psychology 2008, doi:10.1177/0022167808314174
  12. Lee Anna Clark (2006) The role of moral judgment in personality disorder diagnosis Journal of Personality Disorders, 20(2), 184–185
  13. Kleinman A. (1997) Triumph or pyrrhic victory? The inclusion of culture in DSM-IV. Harv Rev Psychiatry. 1997 Mar-Apr;4(6):343-4. PMID 9385013
  14. Bhugra, D. & Munro, A. (1997) Troublesome Disguises: Underdiagnosed Psychiatric Syndromes Blackwell Science Ltd
  15. 15.0 15.1 T. A. Widiger; L. M. Sankis (2000) Adult Psychopathology: Issues and Controversies Annual Review of Psychology, Vol. 51: 377-404 ISSN 00664308
  16. Shankar Vedantam Psychiatry's Missing Diagnosis: Patients' Diversity Is Often Discounted Washington Post: Mind and Culture, June 26
  17. Karasz A (April 2005). "Cultural differences in conceptual models of depression". Social Science in Medicine 60 (7): 1625–35. doi:10.1016/j.socscimed.2004.08.011. PMID 15652693. 
  18. Tilbury, F., Rapley, M. (2004) 'There are orphans in Africa still looking for my hands': African women refugees and the sources of emotional distress Health Sociology Review. Vol 13, Issue 1, 54–64
  19. Bracken P, Thomas P. Postpsychiatry: a new direction for mental health BMJ. 2001 Mar 24;322(7288):724-7.
  20. Lewis, B. (2000) Psychiatry and Postmodern Theory Journal of Medical Humanities, Vol. 21, No. 2, p.71-84
  21. Kwate NO. (2005) The heresy of African-centered psychology. J Med Humanit. 2005 Winter;26(4):215-35.
  22. Kinderman, P. and Lobban, F. (2000) Evolving formulations: Sharing complex information with clients. Behavioral and Cognitive Psychotherapy, 28(3), 307-310.
  23. HealthWise (2004) Mental Health Assessment. Yahoo! Health
  24. Davies, T. (1997) ABC of mental health: Mental health assessment British Medical Journal 314:1536
  25. Kashner TM, Rush AJ, Surís A, Biggs MM, Gajewski VL, Hooker DJ, Shoaf T, Altshuler KZ. (2003) Impact of structured clinical interviews on physicians' practices in community mental health settings. Psychiatr Serv. 2003 May;54(5):712-8. PMID 12719503
  26. Shear MK, Greeno C, Kang J, Ludewig D, Frank E, Swartz HA, Hanekamp M. (2000) Diagnosis of nonpsychotic patients in community clinics. Am J Psychiatry. Apr;157(4):581-7 PMID 10739417
  27. Mind Disorders Encyclopedia Psychosurgery [Retrieved on August 5th 2008]
  28. Mashour GA, Walker EE, Martuza RL. Psychosurgery, Past, Present, and Future. Brain Research Reviews 48 (2005) 409 - 419
  29. Lakhan SE; Vieira KF. Nutritional therapies for mental disorders. Nutrition Journal 2008;7(2).
  30. Harrison G, Hopper K, Craig T, et al (June 2001). "Recovery from psychotic illness: a 15- and 25-year international follow-up study". Br J Psychiatry 178: 506–17. doi:10.1192/bjp.178.6.506. PMID 11388966. http://bjp.rcpsych.org/cgi/pmidlookup?view=long&pmid=11388966. Retrieved on 2008-07-04. 
  31. Jobe TH, Harrow M (December 2005). "Long-term outcome of patients with schizophrenia: a review" (PDF). Canadian Journal of Psychiatry 50 (14): 892–900. PMID 16494258. http://ww1.cpa-apc.org:8080/Publications/Archives/CJP/2005/december/cjp-dec-05-Harrow-IR.pdf. Retrieved on 2008-07-05. 
  32. Tohen M, Zarate CA Jr, Hennen J, Khalsa HM, Strakowski SM, Gebre-Medhin P, Salvatore P, Baldessarini RJ. (2003) The McLean-Harvard First-Episode Mania Study: prediction of recovery and first recurrence Am J Psychiatry. Dec;160(12):2099-107.
  33. JUDD Lewis L.; AKISKAL Hagop S.; SCHETTLER Pamela J. ; ENDICOTT Jean; LEON Andrew C.; SOLOMON David A.; CORYELL William; MASER Jack D.; KELLER Martin B. (2005) Psychosocial disability in the course of bipolar I and II disorders : A prospective, comparative, longitudinal study Archives of General Psychiatry, vol. 62, no12, pp. 1322-1330
  34. 34.0 34.1 34.2 Rogers, A. & Pilgram, D. (2005) A Sociology of Mental Health and Illness, Open University Press, 3rd Edition. ISBN 0335215831
  35. Ferney, V. (2003) The Hierarchy of Mental Illness: Which diagnosis is the least debilitating? New York City Voices Jan/March
  36. WHO International Consortium in Psychiatric Epidemiology (2000) Cross-national comparisons of the prevalences and correlates of mental disorders Bulletin of the World Health Organization v.78 n.4
  37. WHO World Mental Health Survey Consortium. (2004) Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. JAMA. Jun 2;291(21):2581-90.
  38. Somers JM, Goldner EM, Waraich P, Hsu L. (2006) Prevalence and incidence studies of anxiety disorders: a systematic review of the literature. Can J Psychiatry. Feb;51(2):100-13.
  39. Waraich P, Goldner EM, Somers JM, Hsu L. (2004) Prevalence and incidence studies of mood disorders: a systematic review of the literature. Can J Psychiatry. Feb;49(2):124-38.
  40. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. Jun;62(6):593-602.
  41. Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters, EE. (2005) Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry. Jun;62(6):617-27.
  42. US National Institute of Mental Health (2006) The Numbers Count: Mental Disorders in America Retrieved May 2007
  43. ESEMeD/MHEDEA 2000 Investigators, European Study of the Epidemiology of Mental Disorders (ESEMeD) Project. (2004) Prevalence of mental disorders in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project. Acta Psychiatrica Scandinavica Suppl. (420):21-7.
  44. Wittchen, H.U. and Jacobi, F. (2005). Size and burden of mental disorders in Europe - a critical review and appraisal of 27 studies. European Neuropsychopharmacology, 15, 4, pp. 357-76.
  45. Saha S, Chant D, Welham J, McGrath J. (2005) A systematic review of the prevalence of schizophrenia. PLoS Med. 2005 May;2(5):e141.
  46. Torgersen S, Kringlen E, Cramer V. (2001) The prevalence of personality disorders in a community sample. Arch Gen Psychiatry. 2001
  47. Grant BF, Hasin DS, Stinson FS, Dawson DA,Chou SP, Ruan WJ, Pickering RP. (2004) Prevalence, correlates, and disability of personality disorders in the United States: results from the national epidemiologic survey on alcohol and related conditions. J Clin Psychiatry. Jul;65(7):948-58.
  48. Carter, AS., Briggs-Gowan, MJ. & Davis, NO. (2004) Assessment of young children's social-emotional development and psychopathology: recent advances and recommendations for practice. J Child Psychol Psychiatry. Jan;45(1):109-34.
  49. A, N.C. (1997). What is Psychiatry? The American Journal of Psychiatry, 154, 591-593.
  50. University of Melbourne. (2005, August 19). What is Psychiatry?. Retrieved April 19, 2007, from http://www.psychiatry.unimelb.edu.au/info/what_is_psych.html
  51. California Psychiatric Association. (2007, February 28). Frequently Asked Questions About Psychiatry & Psychiatrists. Retrieved April 19, 2007, from http://www.calpsych.org/publications/cpa/faqs.html
  52. American Psychological Association, Division 12, http://www.apa.org/divisions/div12/aboutcp.html
  53. Golightley, M. (2004) Social work and Mental Health Learning Matters, UK
  54. Goldstrom ID, Campbell J, Rogers JA, et al (2006) National estimates for mental health mutual support groups, self-help organizations, and consumer-operated services. Administration and Policy in Mental Health and Mental Health Services Research, 33:92–102
  55. The Joseph Rowntree Foundation (1998) The experiences of mental health service users as mental health professionals
  56. Chamberlin J. (2005) User/consumer involvement in mental health service delivery. Epidemiol Psichiatr Soc. Jan-Mar;14(1):10-4. PMID 15792289
  57. Terence V. McCann, John Baird, Eileen Clark, Sai Lu (2006) Beliefs about using consumer consultants in inpatient psychiatric units International Journal of Mental Health Nursing 15 (4), 258–265.
  58. Everett, B. (1994) Something is happening: the contemporary consumer and psychiatric survivor movement in historical context. Journal of Mind and Behavior, 15:55–7
  59. Rissmiller DJ & Rissmiller JH (2006) Evolution of the antipsychiatry movement into mental health consumerism. Psychiatric Services, Jun;57(6):863-6.
  60. Oaks, D. (2006) The Evolution of the Consumer Movement Psychiatric Services 57:1212
  61. The Antipsychiatry Coalition. (2005, November 26). The Antipsychiatry Coalition. Retrieved April 19, 2007, from www.antipsychiatry.org
  62. Anthony Paul O'Brien, Martin Woods, Christine Palmer (2001) The emancipation of nursing practice: Applying anti-psychiatry to the therapeutic community. Australian and New Zealand Journal of Mental Health Nursing 10 (1), 3–9.
  63. Weitz D. (2003) Call me antipsychiatry activist--not "consumer" Ethical Hum Sci Serv. Spring;5(1):71-2. PMID 15279009
  64. 64.0 64.1 64.2 64.3 World Health Organization (2005) WHO Resource Book on Mental Health: Human rights and legislation ISBN 924156282 (PDF)
  65. Sklar R. Starson v. Swayze: the Supreme Court speaks out (not all that clearly) on the question of "capacity". Can J Psychiatry. 2007 Jun;52(6):390-6.
  66. Manitoba Family Services and Housing. The Vulnerable Persons Living with a Mental Disability Act, 1996
  67. ENABLE website UN section on disability
  68. CAMH: Toronto Star Opinion Editorial: Ending stigma of mental illness
  69. Mental Health: A Report of the Surgeon General - Chapter 8
  70. Heather Stuart (2006) Mental Illness and Employment Discrimination Current Opinion in Psychiatry 19(5):522-526.
  71. Stop Stigma
  72. Read, J., Haslam, N., Sayce, L., Davies, E. (2006) Prejudice and schizophrenia: a review of the 'mental illness is an illness like any other' approach Acta Psychiatrica Scandinavica Nov;114(5):303-18
  73. Study Finds Serious Mental Illness Often Dismissed by Local Church Newswise, Retrieved on October 15, 2008.
  74. Coverdate, J., Nairn, R. & Claasen, D. (2001) Depictions of mental illness in print media: a prospective national sample Australian and New Zealand Journal of Psychiatry, 36 (5), 697–700.
  75. Edney, RD. (2004) Mass Media and Mental Illness: A Literature Review Canadian Mental Health Association
  76. Diefenbach, D.L. (1998) The portrayal of mental illness on prime-time television Journal of Community Psychology Vol 25, Issue 3, Pages 289-302
  77. Sieff, E. (2003) Media frames of mental illnesses: The potential impact of negative frames Journal of Mental Health, Vol 12(3) pp. 259-269
  78. Wahl, O.F. (2003) News Media Portrayal of Mental Illness: Implications for Public Policy American Behavioral Scientist Vol. 46, No. 12, 1594-1600
  79. The Carter Center (2008-07-18), "The Carter Center Awards 2008-2009 Rosalynn Carter Fellowships for Mental Health Journalism", http://www.cartercenter.com/news/pr/mental_health_fellows_2008_2009.html, retrieved on 2008-07-21 
  80. The Carter Center, "The Rosalynn Carter Fellowships For Mental Health Journalism", http://www.cartercenter.com/health/mental_health/fellowships/index.html, retrieved on 2008-07-21 
  81. The Carter Center, "Rosalynn Carter's Advocacy in Mental Health", http://www.cartercenter.com/health/mental_health/rc_advocacy.html, retrieved on 2008-07-21 
  82. Link BG, Phelan JC, Bresnahan M, Stueve A, Pescosolido BA. (1999) Public conceptions of mental illness: labels, causes, dangerousness, and social distance. Am J Public Health. Sep;89(9):1328-33.
  83. Linda A. Teplin, PhD; Gary M. McClelland, PhD; Karen M. Abram, PhD; Dana A. Weiner, PhD (2005) Crime Victimization in Adults With Severe Mental Illness: Comparison With the National Crime Victimization Survey Arch Gen Psychiatry. 62(8):911-921.
  84. Petersilia, J.R. (2001) Crime Victims With Developmental Disabilities: A Review Essay Criminal Justice and Behavior, Vol. 28, No. 6, 655-694 (2001)
  85. 85.0 85.1 Stuart, H. (2003) Violence and mental illness: an overview. World Psychiatry. June; 2(2): 121–124
  86. Brekke JS, Prindle C, Bae SW, Long JD (2001). Risks for individuals with schizophrenia who are living in the community. Psychiatric Services. Oct;52(10):1358–66. PMID 11585953
  87. Pescosolido BA, Monahan J, Link BG, Stueve A, Kikuzawa S. (1999) The public's view of the competence, dangerousness, and need for legal coercion of persons with mental health problems. American Journal of Public Health. Sep;89(9):1339-45.
  88. Steadman HJ, Mulvey EP, Monahan J, Robbins PC, Appelbaum PS, Grisso T, Roth LH, Silver E. (1998) Violence by people discharged from acute psychiatric inpatient facilities and by others in the same neighborhoods. Archives of General Psychiatry. May;55(5):393-401.
  89. Taylor, P.J., Gunn, J. (1999) Homicides by people with mental illness: Myth and reality British Journal of Psychiatry Volume 174, Issue JAN., 1999, Pages 9-14
  90. Solomon, PL., Cavanaugh, MM., Gelles, RJ. (2005) Family Violence among Adults with Severe Mental Illness. Trauma, Violence, & Abuse, Vol. 6, No. 1, 40-54
  91. Chou, KR., Lu, RB., Chang, M. (2001) Assaultive behavior by psychiatric in-patients and its related factors. Journal of Nursing Research. Dec;9(5):139-51
  92. B. Lögdberg, L.-L. Nilsson, M. T. Levander, S. Levander (2004) Schizophrenia, neighborhood, and crime. Acta Psychiatrica Scandinavica, 110(2) Page 92.
  93. 93.0 93.1 93.2 Brüne M, Brüne-Cohrs U, McGrew WC, Preuschoft S. (2006) "Psychopathology in great apes: concepts, treatment options and possible homologies to human psychiatric disorders." Neurosci Biobehav Rev. 30(8):1246-59. PMID 17141312
  94. Fabrega H Jr. (2006) "Making sense of behavioral irregularities of great apes." Neurosci Biobehav Rev. 30(8):1260-73; discussion 1274-7. PMID 17079015
  95. Lilienfeld SO, Gershon J, Duke M, Marino L, de Waal FB. (1999) "A Preliminary Investigation of the Construct of Psychopathic Personality (Psychopathy) in Chimpanzees (Pan troglodytes)" Journal of Comparative Psychology, 113(4), Dec, P365-375 PMID 10608560
  96. Moran, M. (2003) Animals Can Model Psychiatric Symptoms American Psychiatric Association: Psychiatric News June 20, 2003 Volume 38 Number 12
  97. Sanchez, MM, Ladd, CO, Plotsky et al. (2001) Early adverse experience as a developmental risk factor for later psychopathology: Evidence from rodent and primate models Development and Psychopathology (2001), 13: 419-449

Further reading

External links