Intersexuality

Intersexuality is the state of a living thing of a gonochoristic species whose sex chromosomes, genitalia, and/or secondary sex characteristics are determined to be neither exclusively male nor female. An intersex organism may have biological characteristics of both the male and female sexes.[1] Intersexuality is the term adopted by medicine during the 20th century applied to human beings who cannot be classified as either male or female.[2][3][4] Intersexuality is also the word adopted by the identitary-political movement, to criticize medical protocols in sex assignment and to claim the right to be heard in the construction of a new one.[5]

Contents

Language

Research in the late twentieth century has led to a growing medical consensus that diverse intersex physicalities are normal, but relatively rare, forms of human biology. Perhaps the most prominent researcher, Milton Diamond, stresses the importance of care in selection of language related to intersexuality.

“ Foremost, we advocate use of the terms "typical," "usual," or "most frequent" where it is more common to use the term "normal." When possible avoid expressions like maldeveloped or undeveloped, errors of development, defective genitals, abnormal, or mistakes of nature. Emphasize that all of these conditions are biologically understandable while they are statistically uncommon.[6] ”

Nomenclature

Hermaphrodite

The terms hermaphrodite and pseudohermaphrodite, introduced in the 19th century, are now considered problematic as hermaphrodism refers to people who are both completely male and completely female, something not possible.[7] The phrase '"ambiguous genitalia'" refers specifically to genital appearance, but not all intersex conditions result in atypical genital appearance.[8]

Disorders of sex development

The Intersex Society of North America and intersex activists have moved to eliminate the term "intersex" in medical usage, replacing it with "disorders of sex development" (DSD) in order to avoid conflating anatomy with identity.[9] Members of The Lawson Wilkins Pediatric Endocrine Society[10] and the European Society for Paediatric Endocrinology[11] accepted this term in their "Consensus statement on management of intersex disorders" published in the Archives of Disease in Children[12] and in Pediatrics.[13]

The term is defined by congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. However, this has been met with criticism from other activists who question a disease/disability model and advocate no legal definition of sexes, no gender assignments, no legal sex on birth certificates, and no official sexual orientation categories.[14] This particular view has also been cited by some as not only questionable, but offensive to intersex individuals, many of whom do not feel there is "something wrong with them". Alternatives to labeling these as "disorders" have been suggested, including "variations of sex development". [15]

Intersex people in society

History

Intersex individuals are treated in different ways by different cultures. In some cultures intersex people were included in larger "third gender" or gender-blending social roles along with other individuals. In most societies, intersexed individuals have been expected to conform to either a male or female gender role.[16]

Whether or not they were socially tolerated or accepted by any particular culture, the existence of intersex people was known to many ancient and pre-modern cultures.

As an example, one of the Sumerian creation myths from more than 4,000 years ago has Ninmah, a mother goddess, fashioning mankind out of clay.[17] She boasts that she will determine the fate – good or bad – for all she fashions. Enki, the father god, retorts as follows.

Enki answered Ninmah: "I will counterbalance whatever fate -- good or bad -- you happen to decide." Ninmah took clay from the top of the abzu [ab = water, zu = far] in her hand and she fashioned from it first a man who could not bend his outstretched weak hands. Enki looked at the man who cannot bend his outstretched weak hands, and decreed his fate: he appointed him as a servant of the king.
... [Three men and one woman with atypical biology are formed and Enki gives each of them various forms of status to ensure respect for their uniqueness] ...
Sixth, she fashioned one with neither penis nor vagina on its body. Enki looked at the one with neither penis nor vagina on its body and gave it the name Nibru [eunuch(?)], and decreed as its fate to stand before the king."

Since the rise of modern medical science in Western societies, some intersex people with ambiguous external genitalia have had their genitalia surgically modified to resemble either male or female genitals. Ironically since the advancements in surgery have made it possible for intersex conditions to be concealed, many people are not aware of how frequently intersex conditions arise in human beings or that they occur at all. [18] Contemporary social activists, scientists and health practitioners, among others, have begun to revisit the issue, and awareness of the existence of physical sexual variation in human beings is returning.

There are increasing calls for recognition of the various degrees of intersex as healthy variations which should not be subject to correction. Some have attacked the common Western practice of performing corrective surgery on the genitals of intersex people as a Western cultural equivalent of female genital cutting. Despite the attacks on the practice, most of the medical profession still supports it, although activism has radically altered medical policies and how intersex patients and their families are treated.[19] [20] Others, typically social conservatives, have claimed that the talk about third sexes represents an ideological agenda to deride gender as a social construct whereas they believe binary gender (i.e. there is only male and female) is a biological imperative.[21]

Depending on the type of intersex condition, corrective surgery may not be necessary for protection of life or health, but purely for aesthetic or social purposes. Unlike other aesthetic surgical procedures performed on infants, such as corrective surgery for a cleft lip (as opposed to a cleft palate), genital surgery may lead to negative consequences for sexual functioning in later life (such as loss of sensation in the genitals, for example, when a clitoris deemed too large/penile is reduced/removed, or feelings of freakishness and unacceptability) which would have been avoided without the surgery; in other cases negative consequences may be avoided with surgery. Opponents maintain that there is no compelling evidence that the presumed social benefits of such "normalizing" surgery outweigh the potential costs.[22](Similar attitudes are present in some cases of botched infant circumcision, in which the solution might involve intensive medical and parental efforts to reassign the male baby to a female identity, which opponents claim lead to the degrading interpretation that females are essentially castrated males. This view overlooks the embryological origin of the penis/clitoris.) Defenders of the practice argue that it is necessary for individuals to be clearly identified as male or female in order for them to function socially. However, many intersex individuals have resented the medical intervention, and some have been so discontented with their surgically assigned gender as to opt for sexual reassignment surgery later in life.

During the Victorian era, medical authors introduced the terms "true hermaphrodite" for an individual who has both ovarian and testicular gonadal histology, verified under a microscope, "male pseudo-hermaphrodite" for a person with testicular tissue, but either female or ambiguous sexual anatomy, and "female pseudo-hermaphrodite" for a person with ovarian tissue, but either male or ambiguous sexual anatomy. The writer Anne Fausto-Sterling coined the words herm (for "true hermaphrodite"), merm (for "male pseudo-hermaphrodite"), and ferm (for "female pseudo-hermaphrodite"), and proposed that these be recognized as sexes along with male and female. However, her use was "tongue-in-cheek"; she no longer advocates these terms even as a rhetorical device, and her proposed nomenclature was criticized by Cheryl Chase, in a letter to The Sciences which criticized the traditional standard of medical care as well as Fausto-Sterling's shorter names, and announced the creation of the Intersex Society of North America.

Intersex in popular culture

Beginning as early as 1989, intersex became a topic of interest for broadcast TV and radio in the United States and other countries. Jeffrey Eugenides' novel Middlesex (2002) is narrated by an intersex character who discusses the societal experience of an intersex person.[23] The Japanese manga series I.S., first published in 2003, features intersexual characters and how they deal with intersex-related issues and influence the lives of people around them.

Notable intersex people

Noted researchers on intersexed development

Intersex organizations

Response from society

Lack in education

In high school, most emphasis is placed upon the most common XX and XY genotypes. Thus, people nowadays may be more likely to look towards the sex chromosomes than, for example, the histology of the gonads. However, according to researcher Eric Vilain at the University of California, Los Angeles, "the biology of gender is far more complicated than XX or XY chromosomes".[29] Many different criteria have been proposed, and there is little consensus.[30]

Disorders and scope

An image from the Body morphology project shows the chest area of a 38-year-old intersex transgender person who is untreated (no surgery or hormones) for Klinefelter's 46,XY/47,XXY mosaic, which was diagnosed at age 19.

Sax's strict definition of intersex is most relevant to family practice and psychological research. Other interest groups serve different communities and concerns and so broaden the definition of intersex in these fields.

For instance, the Intersex Society of North America (ISNA) definition states that the following conditions "sometimes involve intersex anatomy":[31]

Some people with some of these conditions (such as Kallmann syndrome and Turner syndrome) do not self-identify as intersex. See also 17-beta-hydroxysteroid dehydrogenase deficiency.

Prevalence

The prevalence of intersex depends on which definition is used.

According to the ISNA definition above, 1 percent of live births exhibit some degree of sexual ambiguity, approximately one in every hundred births. [32] Between 0.1% and 0.2% of live births are ambiguous enough to become the subject of specialist medical attention, including surgery to disguise their sexual ambiguity.

According to Fausto-Sterling's definition of intersex[33], on the other hand, 1.7 percent of human births are intersex.[33] She writes,

“ While male and female stand on the extreme ends of a biological continuum, there are many bodies [...] that evidently mix together anatomical components conventionally attributed to both males and females. The implications of my argument for a sexual continuum are profound. If nature really offers us more than two sexes, then it follows that our current notions of masculinity and femininity are cultural conceits.

[...] Modern surgical techniques help maintain the two-sex system. Today children who are born "either/or-neither/both" — a fairly common phenomenon — usually disappear from view because doctors "correct" them right away with surgery.[33]

 ”

According to Leonard Sax the prevalence of intersex "restricted to those conditions in which chromosomal sex is inconsistent with phenotypic sex, or in which the phenotype is not classifiable as either male or female" is about 0.018%.[34]

Signs

Ambiguous genitalia

Ambiguous genitalia of a baby.

Ambiguous genitalia appear as a large clitoris or small penis and may or may not require surgery.

Because there is variation in all of the processes of the development of the sex organs, a child can be born with a sexual anatomy that is typically female, or feminine in appearance with a larger than average clitoris (clitoral hypertrophy); or typically male, masculine in appearance with a smaller than average penis that is open along the underside. The appearance may be quite ambiguous, describable as female genitals with a very large clitoris and partially fused labia, or as male genitals with a very small penis, completely open along the midline ("hypospadic"), and empty scrotum.

Fertility is variable. According to some,[35][36]the distinctions "male pseudohermaphrodite", "female pseudohermaphrodite" and especially "true hermaphrodite"[37] are vestiges of 19th century thinking. According to others, the terms "male pseudohermaphrodite", and "female pseudohermaphrodite" are used to define the gender in terms of the histology (microscopic appearance) of the gonads.[38]

"True hermaphroditism"

With some conditions of intersex, even the chromosomal sex may not be clear. A "true hermaphrodite" is defined as someone with both male gonadal tissue (testes) and female gonadal tissue (ovarian tissue).

In 2004, researchers at UCLA published their studies of a lateral gynandromorphic hermaphroditic bird, which had a testicle on the right and an ovary on the left. Its entire body was split down the middle between male and female, with hormones from both gonads running through the blood.[39]

This extreme example of hermaphroditism is quite rare.

Ovotestes

Although there are no definite reports on any true hermaphroditism in humans, there is, on the other hand, a spectrum of forms of ovotestes. The varieties range, including having two ovotestes or having one ovary and one ovotestis. This is often in the form of streak gonads. Phenotype is not determinable from the ovotestes; in some case the appearance is "fairly typically female," in others it is "fairly typically male," and it may also be "fairly in-between in terms of genital development."[40]

Intersex activist Cheryl Chase is an example of someone with ovotestes.[24]

Other diagnostic signs

In order to help in classification, other methods than a genitalia inspection can be performed:

For instance, a karyotype display of a tissue sample may determine which of the causes of intersex is prevalent in the case.

Management

Management of intersex can be categorized into one of the following two [41]:

  1. Treatments: Restore functionality (or potential functionality)
  2. Enhancements: Give the ability to identify with “mainstream” people e.g. breast enlargement surgery

However, there are other categorisation systems of management of intersexed, which falls into neither category.[42]

In any case, the most common procedure is surgery.

Surgery

The exact procedure of the surgery depends on what is the cause of a less common body phenotype in the first place. There is often concern whether surgery should be performed at all. A traditional approach to the management of Intersexuality has been socially motivated surgery. However, some [42] (Alice Dreger) say that surgical treatment is socially motivated and hence ethically questionable; without evidence doctors regularly assume that intersexed persons can not have a clear identity. This is often taken further with parents of intersexed babies advised that without surgery their child will be stigmatized. Further, since almost all such surgeries are undertaken to fashion female genitalia for the child, it is more difficult for the child to present as male if they later select a male gender identity. 20% to 30% of surgical cases result in a loss of sexual sensation (Newman 1991, 1992).

Conventionally, surgery is performed at birth. Intersex advocates such as Anne Fausto-Sterling in her Sexing the Body argue surgery on intersexed babies should wait until the child can make an informed decision, and label operation without consent as genital mutilation.

Causes

"Mainstream" sex development

Main article: Sexual differentiation

The common pathway of sexual differentiation, where a productive human female has an XX chromosome pair, and a productive male has an XY pair, is relevant to the development of intersexed conditions.

During fertilization, the sperm adds either an X (female) or Y (male) chromosome to the X in the ovum. This determines the genetic sex of the embryo.[43] During the first weeks of development, genetic male and female fetuses are "anatomically indistinguishable," with primitive gonads beginning to develop during approximately the sixth week of gestation. The gonads, in a "bipotential state," may develop into either testes (the male gonads) or ovaries (the female gonads) depending on the consequent events.[43] Through the seventh week, male and female fetuses appear identical.

At around eight weeks of gestation, the gonads of an XY embryo differentiate into functional testes, secreting testosterone. Ovarian differentiation, for XX embryos, does not occur until approximately Week 12 of gestation. In normal female differentiation the Müllerian duct system develops into the uterus, Fallopian tubes, and inner third of the vagina. In males the Müllerian duct-inhibiting hormone MIH causes this duct system to regress. Next, androgens cause the development of the Wolffian duct system, which develops into the vas deferens, seminal vesicles, and ejaculatory ducts.[43] By birth, the typical fetus has been completely "sexed" male or female, the hormones and genital development remaining consistent with the genetic sex.

Conditions

The final body appearance doesn't always correspond with what is dictated by the genes. In other words, there is sometimes an incongruence between genotypic (chromosomal) and phenotypic sex. Although there neither no less common chromosomal sex nor mosaicism/chimerism, but just the most common types (XY or XX), less common phenotypes still appear in such cases. In this sense, the common habit in the 21st century of elevating the role of the sex chromosomes above all other factors when determining gender may be analogous to the older habit of finding "true" sex in the gonads.

This phenomenon complicates the common XY sex-determination system, because it proves that genes don't always definitely correlate to one's perceived sex.[44]

X/Y Name Description
XX Congenital adrenal hyperplasia The most common cause of sexual ambiguity is congenital adrenal hyperplasia (CAH), an endocrine disorder in which the adrenal glands produce abnormally high levels of virilizing hormones. In genetic females, this leads to an appearance that may be slightly masculinized (large clitoris) to quite masculine.
XX Progestin-induced virilisation In this case, the male hormones are caused by use of progestin, a drug that was used in the 1950s and 1960s in order to prevent miscarriage. These individuals normally have internal and external female anatomy, with functional ovaries and will therefore have menstruation. They develop, however, some male secondary characteristics and they frequently have unusually large clitorises. In very advanced cases, such children have initially been identified as boys [45].
XX Freemartinism This condition occurs commonly in all species of cattle and affects most females born as a twin to a male. It is rare or unknown in other mammals, including humans. In cattle, the placentae of fraternal twins usually fuse at some time during the pregnancy, and the twins then share their blood supply. If the twins are of different sexes, male hormones produced in the body of the fetal bull find their way into the body of the fetal heifer (female), and masculinize her. Her sexual organs do not develop fully, and her ovaries may even contain testicular tissue. When adult, such a freemartin is very like a normal female in external appearance, but she is infertile, and behaves more like a castrated male (a steer). The male twin is not significantly affected, although (if he remains entire) his testes may be slightly reduced in size. The degree of masculinization of the freemartin depends on the stage of pregnancy at which the placental fusion occurs – in about ten percent of such births no fusion occurs and both calves develop normally as in other mammals.
XY Androgen insensitivity syndrome People with AIS have typically male chromosomes (XY), along with typically female appearance and genitalia.

Although people with AIS have a vagina, they lack a uterus, cervix of the uterus, and ovaries, and are thereby infertile. The vagina may be shorter than average; in some cases it is nearly absent. Instead of female internal reproductive organs, a person with AIS has undescended or partially descended testes, of which the person may not even be aware.

AIS may be called the genetic male's equivalent of CAH, since AIS affects people with XY genotype, while CAH affects people with XX genotype.

In complete androgen insensitivity syndrome ("CAIS"), the body reads no "male" hormones. In partial androgen insensitivity syndrome (PAIS), however, the body reads some androgens, so virilization occurs to a certain degree. PAIS results in genitalia that may be ambiguous, due to some, although limited, metabolization of the hormones produced by the testes. Ambiguous genitalia most frequently appear as a large clitoris, known as clitoromegaly, or a small penis, which is called as micropenis or microphallus.
XY 5-alpha-reductase deficiency In this condition, individuals have testes, as well as vagina and labia, but with a small penis capable of ejaculation instead of a clitoris (this penis, however, appears to be a clitoris at birth). These individuals are normally raised as girls. However, come puberty, their testes will descend, their voice will deepen and they often will develop a male sexual identity. People with this deficiency develop only limited facial hair.
XY Persistent Müllerian duct syndrome The child has XY chromosomes typical of a male. The child has a male body and an internal uterus and fallopian tubes because his body did not produce Müllerian inhibiting factor during fetal development.
XY Kallmann syndrome This is a specific type of hypogonadotropic hypogonadism (HH) in which the distinguishing symptom is anosmia or hyposmia in addition to the HH symptoms of low levels of pituitary hormones LH and FSH. Kallmann Syndrome is an intersex condition but does cause pubertal delay in both males and females. Some individuals with Kallmann's consider themselves as intersex though some do not. However, this is possibly because they have other conditions such as PAIS in addition to Kallmann's. Such synchronous conditions is only present in a minority of people with Kallmann's, who mostly have no genital abnormality at birth.
Other Less usual chromosomal sex In addition to the most common XX and XY chromosomal sexes, there are quite a few other possible combinations such as Turner syndrome (XO), Triple X syndrome (XXX), Klinefelter syndrome (XXY), XYY syndrome (XYY), XX male, Swyer syndrome (XY female), and there are many other individuals who do not follow the typical patterns (such as individuals with four or even more sex chromosomes).
Other Mosaicism and chimerism A mix can occur, where some of the cells of the body have the common XX or XY, while some have one of the less usual chromosomal contents above. Such a mixture is caused by either mosaicism or chimerism. In mosaicism, the mixture is caused by a mutation in one of the cells of the embryo after fertilization, while chimerism is a fusion of two embryos.

Alternatively, it is simply is a mixture between XX and XY, and doesn't have to involve any less common genotypes in individual cells. This, too, can occur both as a chimerism, or that one sex chromosome has mutated into the other.[46]

On the other hand, however, not all cases of mosaicism and chimerism involve intersex.

Complications

Furthermore, in the cases where nonfunctional testes are present, there is a risk that these develop cancer. Therefore, doctors either remove them by orchidectomy or monitor them carefully. This is the case for instance in androgen insensitivity syndrome.

It should be noted however that there is a growing political intersex movement which argues against labeling these categories as disorders.

See also

References

  1. ↑ On-Line Glossary of Technical Terms in Plant Pathology
  2. ↑ Marañón, Gregorio (1929). Los estados intersexuales en la especie humana. Madrid: Morata. 
  3. ↑ Money, John; Ehrhardt, Anke A. (1972). Man & Woman Boy & Girl. Differentiation and dimorphism of gender identity from conception to maturity. USA: The Johns Hopkins University Press. 
  4. ↑ Domurat Dreger, Alice (2001). Hermaphrodites and the Medical Invention of Sex. USA: Harvard University Press. 
  5. ↑ A world free of shame, secrecy, and unwanted genital surgery Intersex Society of North America
  6. ↑ Diamond, Milton; H. Keith Sigmundson (1997). "Management of intersexuality: Guidelines for dealing with individuals with ambiguous genitalia.". Archives of Pediatrics and Adolescent Medicine June. http://www.hawaii.edu/PCSS/online_artcls/intersex/apam.html. Retrieved on 2007-04-08. 
  7. ↑ Intersex Society of North America (May 24, 2006). Is a person who is intersex a hermaphrodite? Retrieved 25 November, 2006.
  8. ↑ Intersex Society of North America (May 24, 2006). Is intersex the same as "Ambiguous genitalia"? Retrieved 25 November, 2006.
  9. ↑ Intersex Society of North America (May 24, 2006). Why is ISNA using "DSD"? Retrieved June 4, 2006.
  10. ↑ http://www.lwpes.org/ LWPES
  11. ↑ http://www.eurospe.org/ ESPE
  12. ↑ Hughes IA, Houk C, Ahmed SF, Lee PA; LWPES Consensus Group; ESPE Consensus Group. Consensus statement on management of intersex disorders. Arch Dis Child. 2006 July;91(7):554-63. Epub 2006 April 19.
  13. ↑ Lee, P. A., C. P. Houk, S. F. Ahmed, and I. A. Hughes. 2006. Consensus statement on management of intersex disorders. Pediatrics 118 (2):e488-500. http://pediatrics.aappublications.org/cgi/reprint/118/2/e488
  14. ↑ French-speaking Intersex Network of Europe (July 12, 2005). Frequently Asked Questions. Translated from French-speaking by OII. Retrieved June 4, 2006.
  15. ↑ Diamond M, Beh HG (27 July 2006). Variations of Sex Development Instead of Disorders of Sex Development. Arch Dis Child
  16. ↑ Gagnon and Simon 1973
  17. ↑ "The Electronic Text Corpus of Sumerian Literature". Retrieved on 2007-12-09.
  18. ↑ "Ambiguous Sex"--or Ambivalent Medicine? by Alice Domurat Dreger, published in The Hastings Center Report May/Jun 1998, Volume 28, Issue 3 Pages 24-35.
  19. ↑ Richard Ekins, Male Femaling: A Grounded Theory Approach to Cross-dressing and Sex-changing. New York: Routledge 1997, Page 55-M
  20. ↑ Marjorie Garber, Vested Interests: Crossdressing and Cultural Anxiety. New York: Routledge 1992, Page 101
  21. ↑ Sex and Gender are Different: Sexual Identity and Gender Identity are Different, by Milton Diamond, Ph.D., published in Clinical Child Psychology & Psychiatry - Special Issue In Press for July 2002.
  22. ↑ Intersex Society of North America (May 24, 2006). What evidence is there that you can grow up psychologically healthy with intersex genitals (without "normalizing" surgeries)? Retrieved 25 November, 2006.
  23. ↑ Eugenides, Jeffrey (2002). Middlesex. New York: Farrar, Straus, and Giroux. ISBN 0-374-19969-8. 
  24. ↑ 24.0 24.1 Weil, Elizabeth (September, 2006). What if It's (Sort of) a Boy and (Sort of) a Girl? The New York Times Magazine
  25. ↑ Intersex: Case studies. Issue 15 of Cosmos, June 2007 by David Salt and Zoe Brain
  26. ↑ Sinclair, Jim (1997). Self-introduction to the Intersex Society of North America. Jim Sinclair's personal website. Retrieved on 2007-12-02
  27. ↑ "A very unladylike lady!" by Jenny Johnson Daily Mail 10 January 2008
  28. ↑ The gender trap
  29. ↑ Defining male and female
  30. ↑ ISNA. "What is intersex?"
  31. ↑ "Intersex conditions". Retrieved on 2007-12-08.
  32. ↑ How common is intersex? | Intersex Society of North America
  33. ↑ 33.0 33.1 33.2 Fausto-Sterling, Anne (2000). Sexing the Body: Gender Politics and the Construction of Sexuality. New York: Basic Books. 
  34. ↑ Sax, Leonard (2002). "How common is intersex? a response to Anne Fausto-Sterling.". Journal of Sex Research 39 (3): 174–178. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12476264&dopt=Abstract. Retrieved on 2007-04-08. 
  35. ↑ W. S. Alexander M.D., O. D. Beresford M.D,. M.R.C.P. (1953) wrote about extensively about 'female pseudohermaphrodite' origins in utera, in his paper MASCULINIZATION OF OVARIAN ORIGIN, published An International Journal of Obstetrics and Gynaecology Volume 60 Issue 2 Page 252-258, April 1953.
  36. ↑ Am J Psychiatry 164:1499-1505, October 2007: Noted Mayo Clinic researchers J.M. Bostwick, MD.. and Kari A Martin MD in A Man's Brain in an Ambiguous Body: A Case of Mistaken Gender wrote of the distinctions in male pseudohermaphrodite condition.
  37. ↑ Molina B Dayal, MD, MPH, Assistant Professor, Fertility and IVF Center, Division of Reproductive Endocrinology and Infertility, Medical Faculty Associates, George Washington University distingquishes what 'true hermaphroditism' encompases in their study of Ovotestis. Found here: http://www.emedicine.com/med/TOPIC1702.HTM
  38. ↑ Langman, Jan; Thomas Sadler (2006). Langman's medical embryology. Hagerstown, MD: Lippincott Williams & Wilkins. pp. 252. ISBN 0-7817-9485-4. 
  39. ↑ Sax, Leonard (2005). Why Gender Matters: What Parents and Teachers Need to Know About the Emerging Science of Sex Differences. New York: Doubleday. http://whygendermatters.com. 
  40. ↑ "ovo-testes (formerly called "true hermaphroditism")". Retrieved on 2007-12-09.
  41. ↑ Enhancing Human Traits: Ethical and Social Implications Edited by Erik Parens, Washington DC, Georgetown University Press, 1998
  42. ↑ 42.0 42.1 Holmes M. (2002). Rethinking the Meaning and Management of Intersexuality. Sexualities , 159-180."
  43. ↑ 43.0 43.1 43.2 Kolodny, Robert C.; Masters, William H.; Johnson, Virginia E. (1979), Textbook of Sexual Medicine (1st ed.), Little, Brown and Company 
  44. ↑ Intersex Society of North America (May 24, 2006). Does having a Y chromosome make someone a man? Retrieved 25 November, 2006.
  45. ↑ 2000 Intersex Society of North America - What is Progestin Induced Virilisation?
  46. ↑ De Marchi M, Carbonara AO, Carozzi F, et al (1976). "True hermaphroditism with XX/XY sex chromosome mosaicism: report of a case". Clin. Genet. 10 (5): 265–72. PMID 991437. 

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