Developmental biology

"Views of a Fetus in the Womb", Leonardo da Vinci, ca. 1510-1512. The subject of prenatal development is a major subset of developmental biology.

Developmental biology is the study of the process by which organisms grow and develop. Modern developmental biology studies the genetic control of cell growth, differentiation and "morphogenesis," which is the process that gives rise to tissues, organs and anatomy. Developmental biology is that branch of life science,which deals with the study of the process by which organisms grow and develop.

Related fields of study

Embryology is a subfield, the study of organisms between the one-cell stage (generally, the zygote) and the end of the embryonic stage. Embryology was originally a more descriptive science until the 20th century. Embryology and developmental biology today deal with the various steps necessary for the correct and complete formation of the body of a living organism.

The related field of evolutionary developmental biology was formed largely in the 1990s and is a synthesis of findings from molecular developmental biology and evolutionary biology which considers the diversity of organismal form in an evolutionary context.

Perspectives

Developmental genetics is a very helpful process. It studies the effect that genes have in a phenotype. The findings of developmental biology can help to understand developmental malfunctions such as chromosomal aberrations, for example, Down syndrome. An understanding of the specialization of cells during embryogenesis may yield information on how to specialize stem cells to specific tissues and organs, which could lead to the specific cloning of organs for medical purposes. Another biologically important process that occurs during development is apoptosis - programmed cell death or "suicide". For this reason, many developmental models are used to elucidate the physiology and molecular basis of this cellular process. Similarly, a deeper understanding of developmental biology can foster greater progress in the treatment of congenital disorders and diseases, e.g. studying human sex determination can lead to treatment for disorders such as congenital adrenal hyperplasia.

Concepts in developmental biology

Developmental model organisms

Often used model organisms in developmental biology include the following:

• Vertebrates
  • Zebrafish Danio rerio
  • Medakafish Oryzias latipes
  • Fugu Takifugu rubripes
  • Frogs Xenopus laevis
  • Chicken Gallus gallus
  • Mouse Mus musculus (Mammalian embryogenesis)
• Invertebrates
  • Lancelet Branchiostoma lanceolatum
  • Tunicates
  • Sea urchin
  • Round worm Caenorhabditis elegans
  • Fruit fly Drosophila melanogaster (Drosophila embryogenesis)
• Plants (Plant embryogenesis)
  • Arabidopsis thaliana
  • Maize
  • Snapdragon

Developmental systems biology

Computer simulation of multicellular development is a research methodology to understand the function of the very complex processes involved in the development of organisms. This includes simulation of cell signaling, multicell interactions and regulatory genomic networks in development of multicellular structures and processes (see French flag model or Biological Physics of the Developing Embryo for literature). Minimal genomes for minimal multicellular organisms may pave the way to understand such complex processes in vivo.

See also

• Evolutionary developmental biology
• altricial and precocial
• auxology
• fish development
• Important publications in developmental biology
• Plant Evolutionary Developmental Biology

• embryogenesis
• morphogenesis
• Body plan
• Cell signaling
• Signal transduction
• Cell signaling networks
• Transcription factor
• Enhancer
• Enhanceosome
• Promoter
• Gene regulatory network
• Developmental Noise

Sources

• Developmental Biology of Plants and Animals
• Developmental Biology - 8th Edition by Scott Gilbert (online textbook)
• Virtual Library - Developmental Biology
• Latest Developmental Biology News
• Max Planck Institute for Developmental Biology (Tübingen, Germany)