Depersonalization disorder

Depersonalization Disorder Classification and external resources
Goya, Los Caprichos, The Sleep of Reason Produces Monsters, depicts the helplessness an individual with Depersonalization disorder may endure.
ICD-10	F48.1
ICD-9	300.6

Depersonalization Disorder (DSM-IV Dissociative Disorders 300.6^[1]) (DPD) is a dissociative disorder in which the sufferer is affected by persistent or recurrent feelings of depersonalization and/or derealization. The symptoms include a sense of automation, going through the motions of life but not experiencing it, feeling as though one is in a movie, feeling as though one is in a dream, feeling a disconnection from one's body; out-of-body experience, a detachment from one's body, environment and difficulty relating oneself to reality. For all, it is a rather disturbing illness, since many feel that indeed, they are living in a "dream".

Occasional moments of depersonalization are sometimes normal; persistent or recurrent feelings are not. It becomes a disorder when the dissociation is persistent and interferes with the social and occupational functions necessary to everyday living. Often a victim of DPD feels as if he or she is going insane, though this is almost never the case. In most cases, Depersonalization disorder is caused by prolonged emotional, physical and/or sexual abuse. DPD can be considered a defense mechanism as the core symptoms of the disorder, are enforced to protect the victim from any more negative stimuli. Victims of the disorder relatively feel as though their 'individuality' has been lost or changed, occupying this an individual with the disorder may feel as though, when he/she looks in the mirror, he/she feels a "stranger" to him/her self. This is notably due to the detachment of the external environment and due to the detachment of the 'sense of self'.

Depersonalization disorder is often associated as a comorbid disorder of severe anxiety disorders, panic disorders, clinical depression and/or bipolar disorder. Anxiety can exacerbate depersonalization symptoms. In addition, DPD can cause anxiety since the person feels abnormal and uneasy at the loss of their sense of self.

Reality testing remains intact during episodes and continuous depersonalization, meaning that a person suffering from the disorder will be able to respond to questions and interact normally with his or her environment. This fact can be distressing for those with DPD; the friends and family of the victim do not realise that anything is wrong, because a person with DPD will usually not be visibly distraught. While a nuisance, and very distressing to the sufferer, people with depersonalization disorder represent no risk to society, since their grasp on reality remains intact.^[2]

Contents 1 Symptoms 1.1 List of symptoms 2 Causes 3 Pathophysiology 4 Diagnosis 4.1 DSM-IV-TR Criteria 4.2 Differential diagnosis 5 Epidemiology 6 Treatment 7 History 8 Society and culture 9 See also 10 References 11 External links

Symptoms

The core symptom of depersonalization disorder is the subjective experience of unreality. Common descriptions are: watching oneself from a distance; out-of-body experiences; a sense of just going through the motions; feeling as though one is in a dream or movie; not feeling in control of one's speech or physical movements; and feeling detached from one's own thoughts or emotions.^[3] Individuals with the disorder commonly describe a feeling as though time is 'passing' them by and they are not in the notion of the present. These experiences may cause a person to feel uneasy or anxious since they strike at the core of a person's identity and consciousness.

Sufferers retain the ability to distinguish between their own internal experiences and the objective reality of the outside world. Brief periods of depersonalization are notably caused by severe anxiety, stress, a lack of sleep, or a combination.

Some of the more common factors that exacerbate dissociative symptoms are negative effects, stress, subjective threatening social interaction, and unfamiliar environments. Factors that tend to diminish symptoms are comforting interpersonal interactions, intense physical or emotional stimulation, and relaxation.^[4] Fluorescent lighting is reported to increase the effects of depersonalization.

Fears of going crazy, brain damage, and losing control are common complaints. Individuals report occupational impairments as they feel they are working below their ability, and interpersonal troubles since they have an emotional disconnection from those they care about. Neuropsychological testing has shown deficits in attention, short-term memory and spatial-temporal reasoning.^[5]

An analogy is comparing real life to a game, a game everyone plays, all the time. Someone suffering from depersonalization disorder constantly feels as if they cannot get into the game; any stimulus feels contrived or artificial to them. The rules of this game seem to have been forcibly applied upon them (anything from movement, to gravity or hunger) instead of being inherently applicable to them. If understanding dawns upon them of what they should be experiencing, it is often through reason and observation, or the feeling of knowing what and why it is happening. This sort of insight seems to rob everything of its spontaneity, its importance already having been diminished because of their sense of detachment. They are perpetual, and almost all the time cynics of our reality, although unconsciously and involuntarily.

Common words to describe the condition are as follows. Feeling as though I am: a shell, dead, unreal, a zombie, a robot, an automaton. Other descriptives are: Inability to recognize oneself in the mirror and a distorted perception of the body. Most of these symptoms can lead on to making the individual feel as though they are 'invisible'. These symptoms can also be considered derealization and jamais vu. Many people who suffer from Depersonalization disorder also describe a sense of being an observer and participant. For instance, while the individual with the disorder undertakes a specific action or task, a part of him/her questions what he/she is doing. This persistent "nagging" a individual endures with the disorder again produces more anxiety and makes the person feel more mentally detached. Of course, these symptoms can vary with intensity and can have different effects on different people.

List of symptoms

The following list are symptoms of Depersonalization disorder that have been put together from those who suffer from it. Note those who suffer from Depersonalization disorder might not have all of these symptoms:

• Flavor of meals no longer gives a feeling of pleasure or distaste

• Smell of things no longer gives feeling of pleasure or dislike

• Being able to stare into space much more easily

• No emotions felt when weeping or laughing

• Unable to feel affection towards family and friends

• Feeling detached from bodily pain

• Feeling of being a detached observer of oneself

• Feeling of not having any thoughts at all

• Feeling of being outside the body

• Feeling mechanical and ‘robotic’ when moving

• Own voice sounds remote and unreal

• Unable to feel properly things touched with hands

• Urge to touch oneself to be reassured of bodily existence

• Body feels very light, as if it were floating on air

• See oneself outside, as if looking in a mirror

• Surroundings feel detached or unreal

• Things look flat, as if looking at a picture

• When in a new situation, feeling as if it had happened before

• Recently done things feel as if they took place a long time ago

• Unable to picture things in mind

• Personal memories feel as if one had not been involved in them

• Feeling unreal or cutoff from the world

• Body feels as if it didn't belong to oneself

• Not feeling frightened in normally frightening situations

• Favorite activities no longer enjoyable

• Feeling as though objects look smaller or further away

• Previously familiar places look unfamiliar

Causes

Depersonalization disorder has been associated with childhood interpersonal trauma, in particular sexual and emotional abuse. These are significant predictors of depersonalization disorder and depersonalization symptoms.^[6]

Feelings of depersonalization may arise due to life-threatening experiences, such as accidents, assault, or serious illness or injury. The most common immediate precipitants of the disorder are continued severe stress, severe anxiety, major depressive disorder and panic, high grade marijuana and hallucinogen ingestion.^[7]

Depersonalization disorder is most commonly associated with continuous trauma of any type, progressive trauma may lead to the individual dissociating multiple amounts of times and in some cases develop from then on to be distinctively persistent symptoms.

Pathophysiology

Not much is known about the neurobiology of depersonalization disorder; however, a few studies may explain the subjective sense of detachment that forms the core of this dissociative experience. A PET scan found functional abnormalities in the visual, auditory, and somatosensory cortex, as well as areas responsible for an integrated body schema.^[8] In an fMRI study of DPD patients, emotionally aversive scenes activated the right ventral prefrontal cortex. Participants demonstrated a reduced neural response in emotion-sensitive regions, as well as an increased response in regions associated with emotional regulation.^[9] In a similar test of emotional memory, depersonalization disorder patients did not process emotionally salient material in the same way as healthy controls.^[10] In a test of skin conductance responses to unpleasant stimuli, the subjects showed a selective inhibitory mechanism on emotional processing.^[11]

Depersonalization disorder may be associated with dysregulation of the hypothalamic-pituitary-adrenal axis, the area of the brain involved in the "fight-or-flight" response. Patients demonstrate abnormal cortisol levels and basal activity. Studies found that patients with DPD could be distinguished from patients with clinical depression and posttraumatic stress disorder.^[12][13]

Diagnosis

The diagnosis of DPD can be made with the use of various interviews and scales. The Structured Clinical Interview for DSM-IV Dissociative Disorders (SCID-D) is widely used, especially in research settings. This interview takes about 30 minutes to 1.5 hours, depending on individual's experiences.^[14]

The Dissociative Experiences Scale (DES) is a simple, quick, self-administered questionnaire that has been widely used to measure dissociative symptoms.^[15] It has been used in hundreds of dissociative studies, and can detect depersonalization and derealization experiences.

The Dissociative Disorders Interview Schedule (DDIS) is a highly structured interview which makes DSM-IV diagnoses of somatization disorder, borderline personality disorder and major depressive disorder, as well as all the dissociative disorders. It inquires about positive symptoms of schizophrenia, secondary features of dissociative identity disorder, extrasensory experiences, substance abuse and other items relevant to the dissociative disorders. The DDIS can usually be administered in 30–45 minutes.

DSM-IV-TR Criteria

The diagnostic criteria defined in section 300.6 of the Diagnostic and Statistical Manual of Mental Disorders are as follows:

1. Persistent or recurrent feelings of being detached from one’s mental processes or body; as if an observer
2. During depersonalization, reality testing is intact
3. Depersonalization causes significant distress, and impairment in social, occupational, or other functioning
4. Depersonalization is not related to another disorder, substance use, or general medical condition

Differential diagnosis

Some medical and psychiatric conditions mimic the symptoms of DPD. Clinicians must differentiate between and rule out the following to establish a precise diagnosis:

• Temporal lobe epilepsy
• Panic disorder
• Acute stress disorder
• Schizophrenia
• Migraine
• Drug use
• Brain tumour or lesion

Epidemiology

Men and women are affected equally by DPD.^[16] Onset is typically during the teenage years or early 20s, although some report being depersonalized as long as they can remember, and others report a later onset.^[16][4] One study estimates the prevalence of depersonalization disorder at 2.4% of the population.^[17] The onset can be acute or insidious. With acute onset, some individuals remember the exact time and place of their first experience of depersonalization. This may follow a prolonged period of severe stress, a traumatic event, an episode of another mental illness, or drug use. Insidious onset may reach back as far as can be remembered, or it may begin with smaller episodes of lesser severity that gradually become stronger. This disorder is episodic in about one-third of individuals, with each episode lasting from hours to months at a time. Depersonalization can begin episodically, and later become continuous at constant or varying intensity.

Treatment

To date, no treatment recommendations or guidelines for depersonalization disorder have been established. A variety of psychotherapeutic techniques has been used to treat depersonalization disorder (including trauma-focused therapy and cognitive-behavioural techniques), although none of these have established efficacy to date. Clinical pharmacotherapy research continues to explore a number of possible options.

Naloxone was used in a pilot study in 11 patients with chronic DPD. Of the 11 patients, three experienced complete remission, and seven had marked improvement of depersonalization symptoms.^[18] The study only reported immediate treatment results, which makes the efficacy of continued treatment unknown. Naloxone can only be administered intravenously, which makes long-term treatment difficult. Naltrexone was used in a preliminary study in 14 individuals with DPD.^[19] Participants were treated for 6-10 weeks, at a fairly high average dose of 120 milligrams per day. Three individuals were very much improved, another one was much improved, and on average a 30% decrease in depersonalization symptoms were reported. In another study in borderline personality disorder, doses of 200 milligrams per day of naltrexone was reported to decrease general dissociative symptoms over a 2-week period of treatment.^[20]

In a retrospective report of 117 subjects with DPD, 18 of 35 benzodiazepine trials were reported to have led to slight or definite improvement.^[4] Some individuals anecdotally appear to benefit from clonazepam in particular. These drugs are not known to affect the symptoms of dissociation at all, however they do target the often co-morbid anxiety and stress experienced by those with DPD. To date no clinical trials have studied the effectiveness of benzodiazepines.

A series of small studies have suggested a possible role of selective serotonin reuptake inhibitors in treating primary depersonalization disorder. However, a placebo-controlled trial failed to show benefit with fluoxetine in 54 patients with depersonalization disorder.^[21] SSRI treatment created an overall improvement in participants, but only by reducing anxiety and depression. Clomipramine is a tricyclic antidepressant that is helpful with both depression and obsessional disorders. In a study of four subjects treated with clomipramine, two showed clinically significant improvement of DPD.^[22]

History

The word depersonalization itself was first used by Henri Frédéric Amiel in The Journal Intime. The July 8, 1880 entry reads: "I find myself regarding existence as though from beyond the tomb, from another world; all is strange to me; I am, as it were, outside my own body and individuality; I am depersonalized, detached, cut adrift. Is this madness?"^[23]

Society and culture

• Jonathan Caouette, the director of the autobiographical documentary Tarnation, suffers from depersonalization disorder.
• The 2007 film Numb stars Matthew Perry as a screenwriter who suffers from DPD.
• The novel The Stranger by Albert Camus has a protagonist who displays an emotional deadness and view of the world as absurd is reminiscent of DPD.
• In the Bret Easton Ellis novel American Psycho and the 2000 film adaptation of the same name, the protagonist, serial killer Patrick Bateman, remarks repeatedly through first-person narration his feelings of depersonalization, which perhaps contribute to the cause of his murders. Throughout the story, Bateman experiences at some point or another most, if not all, the symptoms of DPD: he frequently experiences panic attacks, hallucinations, random fits of crying, and confusion over his personality (or lack thereof), the latter exacerbated by his compulsion to "fit in" and the inability of his acquaintances to tell him and others apart. Bateman occasionally addresses his ailment directly, including a monologue where he laments, "There wasn't a clear, identifiable emotion within me, except for greed and, possibly, total disgust. I had all the characteristics of a human being—flesh, blood, skin, hair—but my depersonalization was so intense, had gone so deep, that the normal ability to feel compassion had been eradicated, the victim of a slow, purposeful erasure. I was simply imitating reality, a rough resemblance of a human being, with only a dim corner of my mind functioning."
• Simeon D. & Abugel J. (2006) Feeling Unreal : Depersonalization Disorder and the Loss of the Self. Oxford University Press, USA ISBN 0-19-517022-9.

See also

• Dissociation (psychology)
• Dissociative Disorders

References

External links

• Depersonalization Research Abstracts – List of research articles concerning depersonalization disorder.
• Depersonalization Community – Support site for those suffering from depersonalization and derealization.
• DreamChild – Personal page of experiences and advice by one sufferer of chronic depersonalization disorder.
• www.depersonalization.info – Depersonalization disorder information.