Hippocampus

Brain: Hippocampus
Hippocampus.png
The hippocampus is located in the medial temporal lobe of the brain. (In this illustration of the inferior surface (underside) of the brain, the frontal lobe of the brain is at the top, while the occipital lobe is at the bottom.)
Hippocampus-mri.jpg
The location of one of the hippocampi is indicated by the crosshairs
NeuroNames hier-164
MeSH Hippocampus

The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain. In rodents, where it has been studied most extensively, the hippocampus is shaped something like a banana. In humans it has a curved and convoluted shape that reminded early anatomists of a seahorse. The name, in fact, derives from the Greek word for seahorse (Greek: ιππος, hippos = horse, καμπος, kampos = sea monster).

In Alzheimer's disease the hippocampus is one of the first regions of the brain to suffer damage; memory problems and disorientation appear among the first symptoms. Damage to the hippocampus can also result from oxygen starvation (anoxia), encephalitis, or medial temporal lobe epilepsy. People with extensive hippocampal damage may experience amnesia, that is, inability to form or retain new memories.

Contents

Functions of the hippocampus

Perhaps the earliest idea was that the hippocampus is involved in olfaction: this seems to have been suggested mainly by its location in the brain, next to the olfactory cortex. There continues to be some interest in hippocampal olfactory responses, but few people believe today that olfaction is the primary function of the hippocampus.

Over the years, three main ideas of hippocampal function have dominated the literature: inhibition, memory, and space. The behavioral inhibition theory (caricatured by O'Keefe and Nadel as "step on the brakes!") was very popular up to the 1960s. It derived much of its force from two observations: first, animals with hippocampal damage tend to be hyperactive; second, animals with hippocampal damage often have difficulty learning to inhibit responses that they have previously been taught. Jeffrey Gray developed this line of thought into a full-fledged theory of the role of the hippocampus in anxiety[1]. The inhibition theory is not, however, very popular at present.

The second important line of thought relates the hippocampus to memory. Although it has precursors, this idea derived its main force from a very well-known report by Scoville and Milner[2] of the results of surgical destruction of the hippocampus (in an attempt to relieve epileptic seizures), in Henry Gustav Molaison,[3] a patient known as H.M. The unexpected outcome was severe anterograde and partial retrograde amnesia: H.M. was unable to form new episodic memories after his surgery and could not remember any events that occurred just before his surgery, but had memories for things that happened years before such as his childhood. This case occasioned such enormous interest that H.M. is now said to be the most intensively studied medical case in history. In the ensuing years, other patients with similar levels of hippocampal damage and amnesia (caused by accident or disease) have been studied as well, and literally thousands of experiments have studied the physiology of neural plasticity in the hippocampus. There is now almost universal agreement that the hippocampus plays some sort of important role in memory; however, the precise nature of this role remains widely debated[4][5].

The third important line of thought relates the hippocampus to space. The spatial theory was originally championed by O'Keefe and Nadel, who were influenced by E. C. Tolman's theories about "cognitive maps" in humans and animals. O'Keefe and his student Dostrovsky in 1971 discovered neurons in the rat hippocampus that appeared to them to show activity that encoded the rat's location within its environment. O'Keefe and his co-workers, especially Lynn Nadel, continued to investigate this question, in a line of work that eventually led to their very influential 1978 book called "The hippocampus as a cognitive map"[6]. As with the memory theory, there is now almost universal agreement that spatial coding somehow plays an important role in hippocampal function, but the details are widely debated.

Role in general memory

Main article: Amnesia

Psychologists and neuroscientists generally agree that the hippocampus has an important role in the formation of new memories about experienced events (episodic or autobiographical memory)[5][7]. Some researchers prefer to consider the hippocampus as part of a larger medial temporal lobe memory system responsible for general declarative memory (memories that can be explicitly verbalized — these would include, for example, memory for facts in addition to episodic memory)[4].

Some evidence supports the idea that, although these forms of memory often last a lifetime, the hippocampus ceases to play a crucial role in the retention of the memory after a period of consolidation[8]. Damage to the hippocampus usually results in profound difficulties in forming new memories (anterograde amnesia), and normally also affects access to memories prior to the damage (retrograde amnesia). Although the retrograde effect normally extends some years prior to the brain damage, in some cases older memories remain - this sparing of older memories leads to the idea that consolidation over time involves the transfer of memories out of the hippocampus to other parts of the brain. However, experimentation has difficulties in testing the sparing of older memories; and, in some cases of retrograde amnesia, the sparing appears to affect memories formed decades before the damage to the hippocampus occurred, so its role in maintaining these older memories remains uncertain.

Damage to the hippocampus does not affect some aspects of memory, such as the ability to learn new skills (playing a musical instrument, for example), suggesting that such abilities depend on a different type of memory (procedural memory) and different brain regions. And there is evidence to suggest that patient H. M. (who had his medial temporal lobes removed bilaterally as a treatment for epilepsy[2]) can form new semantic memories.[9]

Role in spatial memory and navigation

Main article: Place cell
Spatial firing patterns of 7 place cells recorded from the same location in the dorsal CA1 layer of a rat.The rat ran several hundred laps clockwise around an elevated triangular track, stopping in the middle of each arm to eat a small portion of food reward. Black dots indicate positions of the rat's head; colored dots indicate action potentials from one of the cells, using a different color for each cell.[10]

Evidence suggests the hippocampus is used in storing and processing spatial information. Studies in rats have shown that neurons in the hippocampus have spatial firing fields. These cells are called place cells. Some cells fire when the animal finds itself in a particular location, regardless of direction of travel, while most are at least partially sensitive to head direction and direction of travel. In rats, some cells, termed context-dependent cells, may alter their firing depending on the animal's past (retrospective) or expected future (prospective). Different cells fire at different locations, so that, by looking at the firing of the cells alone, it becomes possible to tell where the animal is. Place cells have now been seen in humans involved in finding their way around in a virtual reality town. The findings resulted from research with individuals with electrodes implanted in their brains as a diagnostic part of surgical treatment for serious epilepsy.[11]

The discovery of place cells led to the idea that the hippocampus might act as a cognitive map — a neural representation of the layout of the environment. Studies with animals have shown that an intact hippocampus is required for simple spatial memory tasks (for instance, finding the way to a hidden goal)[12].

Without a fully functional hippocampus, humans may not remember where they have been and how to get where they are going: getting lost is one of the most common symptoms of amnesia. Brain imaging shows that people have more active hippocampi when correctly navigating, as tested in a computer-simulated "virtual" navigation task[13]. Also, there is evidence that the hippocampus plays a role in finding shortcuts and new routes between familiar places. For example, London's taxi drivers must learn a large number of places and the most direct routes between them (they have to pass a strict test, The Knowledge, before being licensed to drive the famous black cabs). A study at University College London by Maguire, et al (2000)[14] showed that part of the hippocampus is larger in taxi drivers than in the general public, and that more experienced drivers have bigger hippocampi. Whether having a bigger hippocampus helps an individual to become a cab driver or finding shortcuts for a living makes an individual's hippocampus grow is yet to be elucidated. However, in that study Maguire, et al examined the correlation between size of the grey matter and length of time that had been spent as a taxi driver, and found that the longer an individual had spent as a taxi driver, the larger the volume of the right hippocampus. It was found that the total volume of the hippocampus remained constant, from the control group vs. taxi drivers. That is to say that the posterior portion of a taxi driver's hippocampus is indeed increased, but at the expense of the anterior portion. There have been no known detrimental effects reported from this disparity in hippocampal proportions. [14] This finding suggested to the authors that the hippocampus increases in size with use over time.[14]

History

The anatomist Giulio Cesare Aranzi (circa 1564) first used the term hippocampus to describe the cerebral organ because of its visual resemblance to a seahorse. This organ was initially connected with the sense of smell, rather than with its known function in memory acquisition. The Russian Vladimir Bekhterev noted the role of the hippocampus in memory around 1900, based on observations of a patient with profound memory disturbances. However, for many years, the conventional view of the hippocampus was that, like the rest of the limbic system, it was responsible for emotion.

The importance of the hippocampus in memory was brought to the attention of researchers by patient HM. HM suffered from a number of anterograde and temporally-graded retrograde memory impairments (such impairments are the subject of the movie Memento) following the bilateral removal of various medial-temporal lobe structures (including bilateral ablation of his hippocampi) to relieve frequent epileptic seizures. Of particular importance is that HM was still able to learn procedural tasks (which are associated with the striatum) and had an above-average IQ. HM demonstrated a striking single-dissociation between intelligence and declarative memory. The relative size of the hippocampal formation in relation with the total volume of the brain is often conserved in most of the mammalian species. Nevertheless, it has been found that these areas are relatively hypotrophic in cetaceans.

Recently work has been done on creating an artificial version of the CA3 region of the hippocampus using VLSI integrated circuits.[15][16]

Anatomy

Main article: Hippocampus anatomy
Human hippocampus.
Nissl-stained coronal section of the brain of a macaque monkey, showing hippocampus (circled). Source: brainmaps.org

Anatomically, the hippocampus is an elaboration of the edge of the cortex. It can be distinguished as a zone where the cortex narrows into a single layer of very densely packed neurons, which curls into a tight S shape. The structures that line the edge of the cortex make up the so-called limbic system (Latin limbus = border): these include the hippocampus, cingulate cortex, olfactory cortex, and amygdala. Paul MacLean once suggested, as part of his triune brain theory, that the limbic structures comprise the neural basis of emotion. Most neuroscientists no longer believe that the concept of a unified "limbic system" is valid, though.

The hippocampus, as a whole, has the shape of a curved tube, which has been analogized variously to a seahorse, or a ram's horn (Cornu Ammonis), or a banana. It consists of a ventral and dorsal portion, both of which share similar composition but are parts of completely different neural circuits. This general layout holds across the full range of mammalian species, from hedgehog to human, although the details vary. In the rat, the two hippocampi look astonishingly like a pair of bananas, joined at the stem. In human or monkey brains, the portion of the hippocampus down at the bottom, near the base of the temporal lobe, is much broader than the part at the top. One of the consequences of this complex geometry is that cross-sections through the hippocampus can show a variety of shapes, depending on the angle and location of the cut.

The strongest connections of the hippocampus are with the entorhinal cortex (EC), which lies next to it in the temporal lobe. The superficial layers of the EC provide the most numerous inputs to the hippocampus, and the deep layers of the EC receive the most numerous outputs. The EC, in turn, is strongly, and reciprocally, connected with many other parts of the cortex. The hippocampus also receives a very important projection from the medial septal area. Destruction of the septal area abolishes the hippocampal theta rhythm, and severely impairs certain types of memory. (So-called "date rape" drugs are thought to exert their amnestic effects at least partly by antagonizing the cholinergic projection from the medial septum to the hippocampus.)

Physiology

Examples of rat hippocampal EEG and CA1 neural activity in the theta (awake/behaving) and LIA (slow-wave sleep) modes. Each plot show 20 seconds of data, with a hippocampal EEG trace at the top, spike rasters from 40 simultaneously recorded CA1 pyramidal cells in the middle (each raster line represents a different cell), and a plot of running speed at the bottom. The top plot represents a time period during which the rat was actively searching for scattered food pellets. For the bottom plot, the rat was asleep.

The hippocampus shows two major "modes" of activity, each associated with a distinct pattern of EEG waves and neural population activity. These modes are named after the EEG patterns associated with them: theta and large irregular activity (LIA). Here are some of their main characteristics in the rat, the animal that has been most extensively studied:[17]

The theta mode appears during states of active, alert behavior (especially locomotion), and also during REM (dreaming) sleep. In the theta mode, the EEG is dominated by large regular waves with a frequency range of 6-9 Hz, and the main groups of hippocampal neurons (pyramidal cells and granule cells) show sparse population activity, which means that in any short time interval, the great majority of cells are silent, while the small remaining fraction fire at relatively high rates, up to 50 spikes in one second for the most active of them. An active cell typically stays active for from half a second to a few seconds. As the rat behaves, the active cells fall silent and new cells become active, but the overall percentage of active cells remains more or less constant. In many situations, cell activity is determined largely by the spatial location of the animal, but other behavioral variables also clearly influence it.

The LIA mode appears during slow-wave (non-dreaming) sleep, and also during states of waking immobility, such as resting or eating. In the LIA mode, the EEG is dominated by sharp waves, which are randomly-timed large deflections of the EEG signal lasting for 200-300 msec. These sharp waves also determine the population neural activity patterns. Between them, pyramidal cells and granule cells are very quiet (but not silent). During a sharp wave, as many as 5-10% of the population may emit action potentials during a period of 50 msec; many of these cells emit not one but a burst of spikes.

These two hippocapampal activity modes can be seen in primates as well as rats, with the important exception that it has been difficult to see robust theta rhythmicity in the primate hippocampus. There are, however, qualitatively similar sharp waves, and similar state-dependent changes in neural population activity.[18].

The theta rhythm

Because of its densely packed neural layers, the hippocampus generates some of the largest EEG signals of any brain structure. In some situations the EEG is dominated by regular waves, often continuing for many seconds. This EEG pattern is known as the theta rhythm. It was one of the earliest EEG phenomena to be discovered: the first description came from Jung and Kornmuller, in 1938. It was not until 1954, however, with the publication by Green and Arduini of a long and thorough study of theta rhythm in rabbits, cats, and monkeys, that interest really took off.[19] Perhaps largely because they related the theta rhythm to arousal, which was the hot topic of the day, their paper provoked a flood of followup studies, resulting in the publication of literally hundreds of studies of the physiology and pharmacology of theta during the 1950s and 1960s. In spite of this rather daunting body of work, many questions remained unanswered, especially the question of function. Even at present this most critical of questions has not yet been convincingly answered.

Theta rhythmicity is very obvious in rabbits and rodents, and also clearly present in cats and dogs. Whether theta can be seen in primates is a vexing question. Green and Arduini reported only very short bursts of rather irregular rhythmicity in monkeys, and most later studies have seen little more. However, variations in methodology have made it difficult to draw strong conclusions.[20]

In rats (the animals that have been by far the most extensively studied), theta is seen mainly in two conditions: first, when an animal is walking or in some other way actively interacting with its surroundings; second, during REM sleep.[21] The frequency increases as a function of running speed, starting at about 6.5 Hz on the low end, and increasing to about 9 Hz on the high end, although higher frequencies are sometimes seen for dramatic movements such as jumps across wide gaps. In other, larger, species of animals, theta frequencies are generally a bit lower. The behavioral dependency also seems to vary by species: in cats and rabbits, theta is often observed during states of motionless alertness. This has been reported for rats as well, but only when they are severely frightened.[22]

Theta is not just confined to the hippocampus. In rats, it can be observed in many parts of the brain, including nearly all that interact strongly with the hippocampus. The pacemaker for the rhythm is thought to lie within the medial septal area: this area projects to all of the regions that show theta rhythmicity, and destruction of it eliminates theta throughout the brain. (There may be one exception, a small area in the hypothalamus called the supramamillary nucleus, which seems to be capable of sustaining theta independently of the septum in some situations.[23])

The function of theta, presuming it has one, has not yet been convincingly explained, although numerous theories have been proposed.[24] The most popular trend has been to relate it to learning and memory. It is well established that lesions of the medial septum---the central node of the theta system---cause severe disruptions of memory. However, the medium septum is more than just the controller of theta, it is also the main source of cholinergic projections to the hippocampus. It has not been established that septal lesions exert their effects specifically by eliminating theta.

Sharp waves

During sleep, or during waking states when an animal is resting or otherwise not engaged with its surroundings, the hippocampal EEG shows a pattern of irregular slow waves, somewhat larger in amplitude than theta waves. This pattern is occasionally interrupted by large surges called sharp waves. These events are associated with bursts of spike activity, lasting 50-100 msec, in pyramidal cells of CA3 and CA1. They are also associated with short-lasting high-frequency EEG oscillations called "ripples". Ripples, with frequencies in the range 150-200 Hz in rats, can usually be detected only by electrodes located either inside, or very close to, the CA1 cell body layer. In contrast, electrodes located anywhere inside the hippocampus, or even in neighboring brain structures, will often pick up sharp waves as large slow EEG deflections, lasting 200-400 msec.

In rats, sharp waves are most robust during sleep, when they occur at an average rate around 1 per second, but in a very irregular temporal pattern. Sharp waves also occur during inactive waking states, but they are less frequent then and usually smaller. Sharp waves have also been observed in the human temporal lobe and monkey hippocampus. In monkeys, sharp waves are quite robust, but do not occur nearly as frequently as in rats.

One of the most interesting aspects of sharp waves is that they appear to be associated with memory. Wilson and McNaughton 1994, and numerous later studies, reported that when hippocampal place cells have overlapping spatial firing fields (and therefore often fire in near-simultaneity), they tend to show correlated activity during sleep following the behavioral session. This enhancement of correlation, commonly known as reactivation, has been found to be confined mainly to sharp waves. It has been proposed that sharp waves are, in fact, reactivations of neural activity patterns that were memorized during behavior, driven by strengthening of synaptic connections within the hippocampus. This idea forms a key component of the "two-stage memory" theory, advocated by Buzsaki and others, which proposes that memories are stored within the hippocampus during behavior, and then later transferred to the neocortex during sleep: sharp waves are suggested to drive Hebbian synaptic changes in the neocortical targets of hippocampal output pathways.

Role in epilepsy

The hippocampus is often the focus of epileptic seizures: hippocampal sclerosis is the most commonly visible type of tissue damage in temporal lobe epilepsy.[25] It is not yet clear, though, whether the epilepsy is usually caused by hippocampal abnormalities, or the hippocampus is damaged by cumulative effects of seizures. In experimental settings where repetitive seizures are artificially induced in animals, hippocampal damage is a frequent result: this may be a consequence of the hippocampus being one of the most electrically excitable parts of the brain. It may also have something to do with the fact that the hippocampus is one of very few brain regions where new neurons continue to be created throughout life.

Evolution

The hippocampus has a generally similar appearance across the range of mammal species, from basal ones such as the hedgehog to the most "advanced" ones such as humans[26]. The hippocampal-size-to-body-size ratio broadly increases, being about twice as large for primates as for the hedgehog. It does not, however, increase at anywhere close to the rate of the neocortex-to-body-size ratio. Thus, the hippocampus takes up a much larger volume of the cortical mantle in rodents than in primates.

There is also a general relationship between the size of the hippocampus and spatial memory: when comparisons are made between similar species, ones that have a greater capacity for spatial memory tend to have larger hippocampal volumes.[27]. This relationship also extends to sex differences: in species where males and females show strong differences in spatial memory ability, they also tend to show corresponding differences in hippocampal volume[28]

Non-mammalian species do not have a brain structure that looks like the mammalian hippocampus, but they have one that is considered homologous to it. The hippocampus, as pointed out above, is essentially the medial edge of the cortex. Only mammals have a fully developed cortex, but the structure it evolved from, called the pallium, is present in all vertebrates, even the most primitive ones such as the lamprey or hagfish[29]. The pallium is usually divided into three zones: medial, lateral, and dorsal. The medial pallium forms the precursor of the hippocampus. It does not resemble the hippocampus visually, because the layers are not warped into an S shape or enwrapped by the dentate gyrus, but the homology is indicated by strong chemical and functional affinities. There is now evidence that these hippocampal-like structures are involved in spatial cognition in birds, reptiles, and fish.[30]

In birds, the correspondence is sufficiently well established that most anatomists refer to the medial pallial zone as the "avian hippocampus".[31] Numerous species of birds have strong spatial skills, particularly those that cache food. There is evidence that food-caching birds have a larger hippocampus than other types of birds, and that damage to the hippocampus causes impairments in spatial memory.[32].

The story for fish is more complex. In teleost fish (which make up the great majority of existing species), the forebrain is weirdly distorted in comparison to other types of vertebrates. Most neuroanatomists believe that the teleost forebrain is essentially everted, like a sock turned inside-out, so that structures that lie in the interior, next to the ventricles, for most vertebrates, are found on the outside in teleost fish, and vice versa.[33] One of the consequences of this is that the medial pallium ("hippocampal" zone) of a typical vertebrate is thought to correspond to the lateral pallium of a typical fish. Several types of fish (particularly goldfish) have been shown experimentally to have strong spatial memory abilities, even forming "cognitive maps" of the areas they inhabit.[27] There is evidence that damage to the lateral pallium impairs spatial memory.[34] [35] (Long-distance navigation, such as homing by salmon, seems to rely on different mechanisms, however.)

Thus, the role of the hippocampal region in navigation appears to begin far back in vertebrate evolution, predating splits that occurred hundreds of millions of years ago.[36] It is not yet known whether the medial pallium plays a similar role in even more primitive vertebrates, such as sharks and rays, or even lampreys and hagfish. Some types of insects, and molluscs such as the octopus, also have strong spatial learning and navigation abilities, but these appear to work differently from the mammalian spatial system, so there is as yet no good reason to think that they have a common evolutionary origin; nor is there sufficient similarity in brain structure to enable anything resembling a "hippocampus" to be identified in these species.

Notes

  1. ↑ Gray and McNaughton, 2000
  2. ↑ 2.0 2.1 Scoville and Milner, 1957
  3. ↑ "H. M., an Unforgettable Amnesiac, Dies at 82 - Obituary (Obit) - NYTimes.com". Retrieved on 2008-12-06.
  4. ↑ 4.0 4.1 Squire, 1992
  5. ↑ 5.0 5.1 Eichenbaum and Cohen, 1993
  6. ↑ O'Keefe and Nadel, 1978
  7. ↑ Squire and Schacter, 2002
  8. ↑ Squire and Schacter, 2002, Ch. 1
  9. ↑ O'Kane et al., 2004
  10. ↑ Skaggs et al., 1996
  11. ↑ Ekstrom et al., 2003
  12. ↑ Morris et al., 1982
  13. ↑ Maguire et al., 1998
  14. ↑ 14.0 14.1 14.2 Maguire et al., 2000
  15. ↑ "World's first brain prosthesis revealed", by Duncan Graham-Rowe, New Scientist, 12 March, 2003
  16. ↑ "Restoring Lost Cognitive Function--Hippocampal-Cortical Neural Prostheses", by Theodore Berger et al., IEEE Engineering in Medicine and Biology Magazine 24, 5, pp. 30-44, Sept.-Oct. 2005.
  17. ↑ Buzsaki, 2006
  18. ↑ Skaggs et al., 2007
  19. ↑ Green and Arduini, 1954
  20. ↑ Cantero et al., 2003
  21. ↑ Vanderwolf, 1969
  22. ↑ Sainsbury et al., 1987
  23. ↑ Kirk and McNaughton, 1991
  24. ↑ Buzsáki, 2006
  25. ↑ Chang and Lowenstein, 2003
  26. ↑ West, 1990
  27. ↑ 27.0 27.1 Jacobs, 2003
  28. ↑ Jacobs et al., 1990
  29. ↑ Aboitiz et al., 2003
  30. ↑ Rodríguez et al., 2002
  31. ↑ Colombo and Broadbent, 2000
  32. ↑ Shettleworth, 2003
  33. ↑ Nieuwenhuys, 1982
  34. ↑ Portavella et al., 2002
  35. ↑ Vargas et al., 2006
  36. ↑ Broglio et al., 2005

References

  • Aboitiz, F; Morales D, Montiel J (2003). "The evolutionary origin of the mammalian isocortex: Towards an integrated developmental and functional approach". Behav. Brain Sciences 26: 535–552. doi:10.1017/S0140525X03000128. PMID ref15179935. 
  • Amaral, D; Lavenex P (2006). "Ch 3. Hippocampal Neuroanatomy". in Andersen P, Morris R, Amaral D, Bliss T, O'Keefe J. The Hippocampus Book. Oxford University Press. ISBN 9780195100273. 
  • Broglio, C; Gómez A, Durán E, Ocaña FM, Jiménez-Moya F, Rodríguez F, Salas C (2002). "Hallmarks of a common forebrain vertebrate plan: Specialized pallial areas for spatial, temporal and emotional memory in actinopterygian fish". Brain Res. Bull. 57: 397–399. PMID 16144602. 
  • Colombo, M; Broadbent N (2000). "Is the avian hippocampus a functional homologue of the mammalian hippocampus?". Neurosci. Biobehav. Rev. 24: 465–484. doi:10.1016/S0149-7634(00)00016-6. PMID ref10817844. 
  • Eichnbaum, H; Cohen NJ (1993). Memory, Amnesia, and the Hippocampal System. MIT Press. 
  • Gray, JA; McNaughton N (2000). The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System. Oxford University Press. 
  • Jacobs, LF (2003). "The Evolution of the Cognitive Map". Brain Behav. Evol. 62: 128–139. doi:10.1159/000072443. PMID ref12937351. 
  • Kirk, IJ; McNaughton N (1991). "Supramammillary cell firing and hippocampal rhythmical slow activity". Neuroreport 11: 723–725. PMID 1810464. 
  • Morris, RGM; Garrud P, Rawlins JNP, O'Keefe J (1982). "Place navigation impaired in rats with hippocampal lesions.". Nature 297: 681-683. doi:10.1038/297681a0. PMID 7088155. 
  • Nieuwenhuys, R (1982). "An Overview of the Organization of the Brain of Actinopterygian Fishes". Am. Zool. 22: 287–310. doi:10.1093/icb/22.2.287. 
  • Portavella, M; Vargas JP, Torres B, Salas C (2002). "The effects of telencephalic pallial lesions on spatial, temporal, and emotional learning in goldfish". Brain Res. Bull. 57: 397–399. doi:10.1016/S0361-9230(01)00699-2. PMID 11922997. 
  • Rodríguez, F; Lópeza JC, Vargasa JP, Broglioa C, Gómeza Y, Salas C (2002). "Spatial memory and hippocampal pallium through vertebrate evolution: insights from reptiles and teleost fish". Brain Res. Bull. 57: 499–503. doi:10.1016/S0361-9230(01)00682-7. PMID ref11923018. 
  • Sainsbury, RS; Heynen A, Montoya CP (1987). "Behavioral correlates of hippocampal type 2 theta in the rat". Physiol. Behav. 39: 513–519. doi:10.1016/0031-9384(87)90382-9. PMID 3575499. 
  • Shettleworth, SJ (2003). "Memory and Hippocampal Specialization in Food-Storing Birds: Challenges for Research on Comparative Cognition". Brain Behav. Evol. 62: 108–116. doi:10.1159/000072441. PMID ref12937349. 
  • Squire, LR (1992). "Memory and the hippocampus: a synthesis from findings with rats, monkeys, and humans". Psych. Rev. 99: 195–231. doi:10.1037/0033-295X.99.2.195. 
  • Squire, LR; Schacter DL (2002). The Neuropsychology of Memory. Guilford Press. 
  • Vargas, JP; Bingman VP, Portavella M, López JC (2006). "Telencephalon and geometric space in goldfish". Eur. J. Neurosci. 24: 2870–2878. doi:10.1111/j.1460-9568.2006.05174.x. PMID 17156211. 
  • West, MJ (1990). "Stereological studies of the hippocampus: a comparison of the hippocampal subdivisions of diverse species including hedgehogs, laboratory rodents, wild mice and men.". Prog. Brain Res. 83: 13–36. PMID 2203095. 

Additional images

See also

External links

Human brain: Limbic system
Diencephalon
Hypothalamus · Mammillary body
Telencephalon
Limbic lobe
Archicortex: Hippocampal formation (Hippocampus, Alveus of the hippocampus, Subiculum, Perforant path, Fimbria, Dentate gyrus) · Paraterminal gyrus · Supracallosal gyrus
Cingulate gyrus · Parahippocampal gyrus · Uncus
Other
Amygdala · Nucleus accumbens · Orbitofrontal cortex
septum: Septum pellucidum, Septal nuclei
Papez circuit
Diencephalon
Mammillary body → Mammillothalamic tract → Anterior thalamic nucleus →
Telencephalon
Anterior limb of internal capsule → Cingulate gyrus → Cingulum → Parahippocampal gyrus → Entorhinal cortex → Perforant path → Hippocampus/Hippocampal formation (Subiculum) → Fornix →