ZynAddSubFX
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ZynAddSubFX is an open source software synthesizer for Linux and Microsoft Windows.
For sound generation it has three hybrid synth engines that combine additive, subtractive, Fourier and other synthesis methods. No external samples are used to produce the sound; everything is done by synthesis. The synthesizer has effects like: Reverberation, Echo, Chorus, Distortion, Equalizer and others and supports microtonal tunings. The author of ZynAddSubFX is a Romanian programmer, Paul Nasca. The work started by March 2002 and the first public release was version 1.0.0 in September 2002.
A limited Mac OS X version was released by Ben Powers. A windows port is in early stages, as well as a VST implementation.