ZWINT

From Wikipedia, the free encyclopedia

ZW10 interactor

Identifiers

ZWINT; HZwint-1; KNTC2AP; MGC117174

External IDs

OMIM: 609177 MGI: 1289227 HomoloGene: 48496

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• chromosome, pericentric region • nucleus
Biological Process:	• cell cycle • spindle organization and biogenesis • mitosis • phosphoinositide-mediated signaling • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001005413 (mRNA)
NP_001005413 (protein)

NM_025635 (mRNA)
NP_079911 (protein)

Location

Chr 10: 57.79 - 57.79 Mb

Chr 10: 72.05 - 72.07 Mb

Pubmed search

[1]

[2]

ZW10 interactor, also known as ZWINT, is a human gene.^[1]

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZWINT ZW10 interactor.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Starr DA, Saffery R, Li Z, et al. (2000). "HZwint-1, a novel human kinetochore component that interacts with HZW10.". J. Cell. Sci. 113 ( Pt 11): 1939–50. PMID 10806105.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Musio A, Mariani T, Montagna C, et al. (2004). "Recapitulation of the Roberts syndrome cellular phenotype by inhibition of INCENP, ZWINT-1 and ZW10 genes.". Gene 331: 33–40. doi:10.1016/j.gene.2004.01.028. PMID 15094189.
Cheeseman IM, Niessen S, Anderson S, et al. (2004). "A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.". Genes Dev. 18 (18): 2255–68. doi:10.1101/gad.1234104. PMID 15371340.
Wang H, Hu X, Ding X, et al. (2005). "Human Zwint-1 specifies localization of Zeste White 10 to kinetochores and is essential for mitotic checkpoint signaling.". J. Biol. Chem. 279 (52): 54590–8. doi:10.1074/jbc.M407588200. PMID 15485811.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Obuse C, Iwasaki O, Kiyomitsu T, et al. (2004). "A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1.". Nat. Cell Biol. 6 (11): 1135–41. doi:10.1038/ncb1187. PMID 15502821.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Kops GJ, Kim Y, Weaver BA, et al. (2005). "ZW10 links mitotic checkpoint signaling to the structural kinetochore.". J. Cell Biol. 169 (1): 49–60. doi:10.1083/jcb.200411118. PMID 15824131.
Lin YT, Chen Y, Wu G, Lee WH (2006). "Hec1 sequentially recruits Zwint-1 and ZW10 to kinetochores for faithful chromosome segregation and spindle checkpoint control.". Oncogene 25 (52): 6901–14. doi:10.1038/sj.onc.1209687. PMID 16732327.