ZRF1

From Wikipedia, the free encyclopedia

Zuotin related factor 1

Identifiers

ZRF1; MPP11; DNAJC2; MPHOSPH11; ZUO1

External IDs

OMIM: 605502 MGI: 99470 HomoloGene: 31656

Gene ontology
Molecular Function:	• DNA binding • heat shock protein binding • unfolded protein binding
Cellular Component:	• nucleus • membrane • integral to membrane
Biological Process:	• G2 phase of mitotic cell cycle • DNA replication • protein folding

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_014377 (mRNA)
NP_055192 (protein)

NM_009584 (mRNA)
NP_033610 (protein)

Location

n/a

Chr 5: 21.27 - 21.3 Mb

Pubmed search

[1]

[2]

Zuotin related factor 1, also known as ZRF1, is a human gene.^[1]

This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZRF1 zuotin related factor 1.

[edit] Further reading

Matsumoto-Taniura N, Pirollet F, Monroe R, et al. (1997). "Identification of novel M phase phosphoproteins by expression cloning.". Mol. Biol. Cell 7 (9): 1455-69. PMID 8885239.
Resto VA, Caballero OL, Buta MR, et al. (2000). "A putative oncogenic role for MPP11 in head and neck squamous cell cancer.". Cancer Res. 60 (19): 5529-35. PMID 11034098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Greiner J, Ringhoffer M, Taniguchi M, et al. (2003). "Characterization of several leukemia-associated antigens inducing humoral immune responses in acute and chronic myeloid leukemia.". Int. J. Cancer 106 (2): 224-31. doi:10.1002/ijc.11200. PMID 12800198.
Greiner J, Ringhoffer M, Taniguchi M, et al. (2004). "mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies.". Int. J. Cancer 108 (5): 704-11. doi:10.1002/ijc.11623. PMID 14696097.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Hundley HA, Walter W, Bairstow S, Craig EA (2005). "Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitous.". Science 308 (5724): 1032-4. doi:10.1126/science.1109247. PMID 15802566.
Otto H, Conz C, Maier P, et al. (2005). "The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex.". Proc. Natl. Acad. Sci. U.S.A. 102 (29): 10064-9. doi:10.1073/pnas.0504400102. PMID 16002468.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.