ZNRF1

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Zinc and ring finger 1
Identifiers
Symbol(s) ZNRF1; DKFZp434E229; FLJ14846; MGC15430; NIN283
External IDs MGI: 2177308 HomoloGene: 41858
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 84937 170737
Ensembl ENSG00000186187 ENSMUSG00000033545
Refseq NM_032268 (mRNA)
NP_115644 (protein)		 NM_133206 (mRNA)
NP_573469 (protein)
Location Chr 16: 73.59 - 73.7 Mb Chr 8: 114.42 - 114.51 Mb
Pubmed search [1] [2]

Zinc and ring finger 1, also known as ZNRF1, is a human gene.[1]

In a study identifying genes in rat that are upregulated in response to nerve damage, a gene which is highly expressed in ganglia and in the central nervous system was found. The protein encoded by the rat gene contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification. The protein encoded by this human gene is highly similar in sequence to that encoded by the rat gene.[1]

[edit] References

  1. ^ a b Entrez Gene: ZNRF1 zinc and ring finger 1.

[edit] Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863. 
  • Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166. 
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614. 
  • Araki T, Nagarajan R, Milbrandt J (2001). "Identification of genes induced in peripheral nerve after injury. Expression profiling and novel gene discovery.". J. Biol. Chem. 276 (36): 34131–41. doi:10.1074/jbc.M104271200. PMID 11427537. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Araki T, Milbrandt J (2003). "ZNRF proteins constitute a family of presynaptic E3 ubiquitin ligases.". J. Neurosci. 23 (28): 9385–94. PMID 14561866. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901. 
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