ZNF423

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Zinc finger protein 423
Identifiers
Symbol(s) ZNF423; OAZ; Ebfaz; KIAA0760; MGC138520; MGC138522; Roaz; Zfp104
External IDs OMIM: 604557 MGI: 1891217 HomoloGene: 9010
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23090 94187
Ensembl ENSG00000102935 ENSMUSG00000045333
Refseq NM_015069 (mRNA)
NP_055884 (protein)		 XM_001000774 (mRNA)
XP_001000774 (protein)
Location Chr 16: 48.08 - 48.42 Mb Chr 8: 90.58 - 90.79 Mb
Pubmed search [1] [2]

Zinc finger protein 423, also known as ZNF423, is a human gene.[1]

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development.[1]

[edit] References

  1. ^ a b Entrez Gene: ZNF423 zinc finger protein 423.

[edit] Further reading

  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Ku MC, Stewart S, Hata A (2004). "Poly(ADP-ribose) polymerase 1 interacts with OAZ and regulates BMP-target genes.". Biochem. Biophys. Res. Commun. 311 (3): 702–7. PMID 14623329. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Shim S, Bae N, Han JK (2002). "Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ).". Nucleic Acids Res. 30 (14): 3107–17. PMID 12136093. 
  • Hata A, Seoane J, Lagna G, et al. (2000). "OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.". Cell 100 (2): 229–40. PMID 10660046. 
  • Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452. 
  • Tsai RY, Reed RR (1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development.". J. Neurosci. 17 (11): 4159–69. PMID 9151733. 
  • Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. 
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