ZMYND11

From Wikipedia, the free encyclopedia

Zinc finger, MYND domain containing 11

Identifiers

ZMYND11; BRAM1; BS69; MGC111056; RP11-486H9.1

External IDs

OMIM: 608668 MGI: 1913755 HomoloGene: 4828

Gene ontology
Molecular Function:	• DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • ubiquitin cycle • cell cycle • cell proliferation • negative regulation of progression through cell cycle

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006624 (mRNA)
NP_006615 (protein)

NM_144516 (mRNA)
NP_653099 (protein)

Location

Chr 10: 0.17 - 0.29 Mb

Chr 13: 9.68 - 9.76 Mb

Pubmed search

[1]

[2]

Zinc finger, MYND domain containing 11, also known as ZMYND11, is a human gene.^[1]

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZMYND11 zinc finger, MYND domain containing 11.

[edit] Further reading

Hateboer G, Gennissen A, Ramos YF, et al. (1995). "BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation.". EMBO J. 14 (13): 3159–69. PMID 7621829.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Kurozumi K, Nishita M, Yamaguchi K, et al. (1998). "BRAM1, a BMP receptor-associated molecule involved in BMP signalling.". Genes Cells 3 (4): 257–64. PMID 9663660.
Masselink H, Bernards R (2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR.". Oncogene 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.
Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif.". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
Ansieau S, Leutz A (2002). "The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif.". J. Biol. Chem. 277 (7): 4906–10. doi:10.1074/jbc.M110078200. PMID 11733528.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Wei G, Schaffner AE, Baker KM, et al. (2003). "Ets-2 interacts with co-repressor BS69 to repress target gene expression.". Anticancer Res. 23 (3A): 2173–8. PMID 12894593.
Hughes-Davies L, Huntsman D, Ruas M, et al. (2004). "EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer.". Cell 115 (5): 523–35. PMID 14651845.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Isobe T, Uchida C, Hattori T, et al. (2006). "Ubiquitin-dependent degradation of adenovirus E1A protein is inhibited by BS69.". Biochem. Biophys. Res. Commun. 339 (1): 367–74. doi:10.1016/j.bbrc.2005.11.028. PMID 16300738.
Wan J, Zhang W, Wu L, et al. (2006). "BS69, a specific adaptor in the latent membrane protein 1-mediated c-Jun N-terminal kinase pathway.". Mol. Cell. Biol. 26 (2): 448–56. doi:10.1128/MCB.26.2.448-456.2006. PMID 16382137.
Velasco G, Grkovic S, Ansieau S (2006). "New insights into BS69 functions.". J. Biol. Chem. 281 (24): 16546–50. doi:10.1074/jbc.M600573200. PMID 16565076.