ZMYM2

From Wikipedia, the free encyclopedia

Zinc finger, MYM-type 2

Identifiers

ZMYM2; FIM; MYM; RAMP; SCLL; ZNF198

External IDs

OMIM: 602221 MGI: 1923257 HomoloGene: 12631

Gene ontology
Molecular Function:	• protein binding • zinc ion binding • metal ion binding
Cellular Component:	• cellular_component • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003453 (mRNA)
NP_003444 (protein)

NM_029498 (mRNA)
NP_083774 (protein)

Location

Chr 13: 19.43 - 19.56 Mb

Chr 14: 55.84 - 55.91 Mb

Pubmed search

[1]

[2]

Zinc finger, MYM-type 2, also known as ZMYM2, is a human gene.^[1]

[edit] References

^ Entrez Gene: ZMYM2 zinc finger, MYM-type 2.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Xiao S, Nalabolu SR, Aster JC, et al. (1998). "FGFR1 is fused with a novel zinc-finger gene, ZNF198, in the t(8;13) leukaemia/lymphoma syndrome.". Nat. Genet. 18 (1): 84–7. doi:10.1038/ng0198-84. PMID 9425908.
Smedley D, Hamoudi R, Clark J, et al. (1998). "The t(8;13)(p11;q11-12) rearrangement associated with an atypical myeloproliferative disorder fuses the fibroblast growth factor receptor 1 gene to a novel gene RAMP.". Hum. Mol. Genet. 7 (4): 637–42. PMID 9499416.
Popovici C, Adélaïde J, Ollendorff V, et al. (1998). "Fibroblast growth factor receptor 1 is fused to FIM in stem-cell myeloproliferative disorder with t(8;13).". Proc. Natl. Acad. Sci. U.S.A. 95 (10): 5712–7. PMID 9576949.
Still IH, Cowell JK (1998). "The t(8;13) atypical myeloproliferative disorder: further analysis of the ZNF198 gene and lack of evidence for multiple genes disrupted on chromosome 13.". Blood 92 (4): 1456–8. PMID 9694738.
Reiter A, Sohal J, Kulkarni S, et al. (1998). "Consistent fusion of ZNF198 to the fibroblast growth factor receptor-1 in the t(8;13)(p11;q12) myeloproliferative syndrome.". Blood 92 (5): 1735–42. PMID 9716603.
Kulkarni S, Reiter A, Smedley D, et al. (1999). "The genomic structure of ZNF198 and location of breakpoints in the t(8;13) myeloproliferative syndrome.". Genomics 55 (1): 118–21. doi:10.1006/geno.1998.5634. PMID 9889006.
Ollendorff V, Guasch G, Isnardon D, et al. (1999). "Characterization of FIM-FGFR1, the fusion product of the myeloproliferative disorder-associated t(8;13) translocation.". J. Biol. Chem. 274 (38): 26922–30. PMID 10480903.
Matsumoto K, Morita K, Takada S, et al. (2000). "A chronic myelogenous leukemia-like myeloproliferative disorder accompanied by T-cell lymphoblastic lymphoma with chromosome translocation t(8;13)(p11;q12): a Japanese case.". Int. J. Hematol. 70 (4): 278–82. PMID 10643154.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Hakimi MA, Dong Y, Lane WS, et al. (2003). "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes.". J. Biol. Chem. 278 (9): 7234–9. doi:10.1074/jbc.M208992200. PMID 12493763.
Baumann H, Kunapuli P, Tracy E, Cowell JK (2003). "The oncogenic fusion protein-tyrosine kinase ZNF198/fibroblast growth factor receptor-1 has signaling function comparable with interleukin-6 cytokine receptors.". J. Biol. Chem. 278 (18): 16198–208. doi:10.1074/jbc.M300018200. PMID 12594223.
Kunapuli P, Somerville R, Still IH, Cowell JK (2003). "ZNF198 protein, involved in rearrangement in myeloproliferative disease, forms complexes with the DNA repair-associated HHR6A/6B and RAD18 proteins.". Oncogene 22 (22): 3417–23. doi:10.1038/sj.onc.1206408. PMID 12776193.
Warner DR, Roberts EA, Greene RM, Pisano MM (2004). "Identification of novel Smad binding proteins.". Biochem. Biophys. Res. Commun. 312 (4): 1185–90. PMID 14651998.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13.". Nature 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.