ZHX3

From Wikipedia, the free encyclopedia

Zinc fingers and homeoboxes 3

PDB rendering based on 2da5.

Available structures: 2da5, 2dn0

Identifiers

Symbol(s)

ZHX3; KIAA0395; TIX1

External IDs

OMIM: 609598 MGI: 2444772 HomoloGene: 9000

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of transcription, DNA-dependent • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015035 (mRNA)
NP_055850 (protein)

NM_177263 (mRNA)
NP_796237 (protein)

Location

Chr 20: 39.24 - 39.38 Mb

Chr 2: 160.46 - 160.55 Mb

Pubmed search

[1]

[2]

Zinc fingers and homeoboxes 3, also known as ZHX3, is a human gene.^[1]

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZHX3 zinc fingers and homeoboxes 3.

[edit] Further reading

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99–106. PMID 12168954.
Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3.". Gene 323: 133–40. PMID 14659886.
Yamada K, Kawata H, Shou Z, et al. (2003). "Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3.". Biochem. J. 373 (Pt 1): 167–78. doi:10.1042/BJ20021866. PMID 12659632.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jia L, Young MF, Powell J, et al. (2002). "Gene expression profile of human bone marrow stromal cells: high-throughput expressed sequence tag sequencing analysis.". Genomics 79 (1): 7–17. doi:10.1006/geno.2001.6683. PMID 11827452.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. PMID 9455477.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.