ZHX2

From Wikipedia, the free encyclopedia

Zinc fingers and homeoboxes 2

PDB rendering based on 2dmp.

Available structures: 2dmp

Identifiers

Symbol(s)

ZHX2; KIAA0854

External IDs

OMIM: 609185 MGI: 2683087 HomoloGene: 8968

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• mRNA catabolic process • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014943 (mRNA)
NP_055758 (protein)

XM_989653 (mRNA)
XP_994747 (protein)

Location

Chr 8: 123.86 - 124.06 Mb

Chr 15: 57.52 - 57.67 Mb

Pubmed search

[1]

[2]

Zinc fingers and homeoboxes 2, also known as ZHX2, is a human gene.^[1]

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZHX2 zinc fingers and homeoboxes 2.

[edit] Further reading

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (6): 355–64. PMID 10048485.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kawata H, Yamada K, Shou Z, et al. (2003). "Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor.". Biochem. J. 373 (Pt 3): 747–57. doi:10.1042/BJ20030171. PMID 12741956.
Kawata H, Yamada K, Shou Z, et al. (2004). "The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3.". Gene 323: 133–40. PMID 14659886.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
de Andrade TG, Peterson KR, Cunha AF, et al. (2006). "Identification of novel candidate genes for globin regulation in erythroid cells containing large deletions of the human beta-globin gene cluster.". Blood Cells Mol. Dis. 37 (2): 82–90. doi:10.1016/j.bcmd.2006.07.003. PMID 16952470.
Liu G, Clement LC, Kanwar YS, et al. (2007). "ZHX proteins regulate podocyte gene expression during the development of nephrotic syndrome.". J. Biol. Chem. 281 (51): 39681–92. doi:10.1074/jbc.M606664200. PMID 17056598.
Hu S, Zhang M, Lv Z, et al. (2007). "Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis.". Neoplasma 54 (3): 207–11. PMID 17447851.