ZFY

From Wikipedia, the free encyclopedia

Zinc finger protein, Y-linked

PDB rendering based on 1klr.

Available structures: 1klr, 5znf

Identifiers

Symbol(s)

ZFY; MGC138710

External IDs

OMIM: 490000 HomoloGene: 88465

Gene ontology
Molecular Function:	• DNA binding • zinc ion binding • transcription regulator activity • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

n/a

Refseq

NM_003411 (mRNA)
NP_003402 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr Y: 2.86 - 2.91 Mb

n/a

Pubmed search

[1]

n/a

Zinc finger protein, Y-linked, also known as ZFY, is a human gene.^[1]

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZFY zinc finger protein, Y-linked.

[edit] Further reading

Merchant-Larios H, Moreno-Mendoza N (2002). "Onset of sex differentiation: dialog between genes and cells.". Arch. Med. Res. 32 (6): 553-8. PMID 11750730.
Kochoyan M, Havel TF, Nguyen DT, et al. (1991). "Alternating zinc fingers in the human male associated protein ZFY: 2D NMR structure of an even finger and implications for "jumping-linker" DNA recognition.". Biochemistry 30 (14): 3371-86. PMID 1849423.
Kochoyan M, Keutmann HT, Weiss MA (1991). "Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition.". Biochemistry 30 (29): 7063-72. PMID 1854720.
North M, Sargent C, O'Brien J, et al. (1991). "Comparison of ZFY and ZFX gene structure and analysis of alternative 3' untranslated regions of ZFY.". Nucleic Acids Res. 19 (10): 2579-86. PMID 2041734.
Palmer MS, Berta P, Sinclair AH, et al. (1990). "Comparison of human ZFY and ZFX transcripts.". Proc. Natl. Acad. Sci. U.S.A. 87 (5): 1681-5. PMID 2308929.
Müller G, Schempp W (1989). "Mapping the human ZFX locus to Xp21.3 by in situ hybridization.". Hum. Genet. 82 (1): 82-4. PMID 2497060.
Affara NA, Chambers D, O'Brien J, et al. (1989). "Evidence for distinguishable transcripts of the putative testis determining gene (ZFY) and mapping of homologous cDNA sequences to chromosomes X,Y and 9.". Nucleic Acids Res. 17 (8): 2987-99. PMID 2498838.
Lau YF, Chan KM (1990). "The putative testis-determining factor and related genes are expressed as discrete-sized transcripts in adult gonadal and somatic tissues.". Am. J. Hum. Genet. 45 (6): 942-52. PMID 2511751.
Page DC, Mosher R, Simpson EM, et al. (1988). "The sex-determining region of the human Y chromosome encodes a finger protein.". Cell 51 (6): 1091-104. PMID 3690661.
Tricoli JV, Bracken RB (1993). "ZFY gene expression and retention in human prostate adenocarcinoma.". Genes Chromosomes Cancer 6 (2): 65-72. PMID 7680890.
Erlandsson R, Wilson JF, Pääbo S (2000). "Sex chromosomal transposable element accumulation and male-driven substitutional evolution in humans.". Mol. Biol. Evol. 17 (5): 804-12. PMID 10779541.
Mittwoch U (2001). "Three thousand years of questioning sex determination.". Cytogenet. Cell Genet. 91 (1-4): 186-91. PMID 11173854.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003). "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.". Nature 423 (6942): 825-37. doi:10.1038/nature01722. PMID 12815422.
Agate RJ, Choe M, Arnold AP (2004). "Sex differences in structure and expression of the sex chromosome genes CHD1Z and CHD1W in zebra finches.". Mol. Biol. Evol. 21 (2): 384-96. doi:10.1093/molbev/msh027. PMID 14660691.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.