ZFYVE1

From Wikipedia, the free encyclopedia

Zinc finger, FYVE domain containing 1

Identifiers

ZFYVE1; DFCP1; KIAA1589; TAFF1; ZNFN2A1

External IDs

OMIM: 605471 MGI: 3026685 HomoloGene: 10945

Gene ontology
Molecular Function:	• phosphatidylinositol binding • phosphatidylinositol-3,4,5-triphosphate binding • zinc ion binding • phosphatidylinositol-3,4-bisphosphate binding • metal ion binding
Cellular Component:	• endoplasmic reticulum • Golgi stack • perinuclear region of cytoplasm
Biological Process:	• vesicle-mediated transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021260 (mRNA)
NP_067083 (protein)

NM_183154 (mRNA)
NP_898977 (protein)

Location

Chr 14: 72.51 - 72.56 Mb

Chr 12: 84.44 - 84.49 Mb

Pubmed search

[1]

[2]

Zinc finger, FYVE domain containing 1, also known as ZFYVE1, is a human gene.^[1]

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1.

[edit] Further reading

Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. PMID 10997877.
Derubeis AR, Young MF, Jia L, et al. (2000). "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library.". Gene 255 (2): 195–203. PMID 11024279.
Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (2001). "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi.". Biochem. J. 355 (Pt 1): 113–21. PMID 11256955.
Ridley SH, Ktistakis N, Davidson K, et al. (2002). "FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments.". J. Cell. Sci. 114 (Pt 22): 3991–4000. PMID 11739631.
Krugmann S, Anderson KE, Ridley SH, et al. (2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.". Mol. Cell 9 (1): 95–108. PMID 11804589.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14.". Nature 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874.