ZFYVE16

From Wikipedia, the free encyclopedia

Zinc finger, FYVE domain containing 16

Identifiers

ZFYVE16; DKFZp686E13162; ENDOFIN; KIAA0305

External IDs

OMIM: 608880 MGI: 2145181 HomoloGene: 8826

Gene ontology
Molecular Function:	• protein binding • phosphatidylinositol binding • zinc ion binding • protein transporter activity • metal ion binding
Cellular Component:	• early endosome • membrane
Biological Process:	• protein targeting to lysosome • signal transduction • vesicle organization and biogenesis • endosome transport • regulation of endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014733 (mRNA)
NP_055548 (protein)

NM_173392 (mRNA)
NP_775568 (protein)

Location

Chr 5: 79.74 - 79.81 Mb

Chr 13: 93.59 - 93.63 Mb

Pubmed search

[1]

[2]

Zinc finger, FYVE domain containing 16, also known as ZFYVE16, is a human gene.^[1]

The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule (Seet et al., 2004).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ZFYVE16 zinc finger, FYVE domain containing 16.

[edit] Further reading

Nagase T, Ishikawa K, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 4 (2): 141–50. PMID 9205841.
Seet LF, Hong W (2001). "Endofin, an endosomal FYVE domain protein.". J. Biol. Chem. 276 (45): 42445–54. doi:10.1074/jbc.M105917200. PMID 11546807.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Seet LF, Liu N, Hanson BJ, Hong W (2004). "Endofin recruits TOM1 to endosomes.". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. PMID 14613930.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Zhao BM, Hoffmann FM (2006). "Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA.". Mol. Biol. Cell 17 (9): 3819–31. doi:10.1091/mbc.E05-10-0990. PMID 16775010.
Chen YG, Wang Z, Ma J, et al. (2007). "Endofin, a FYVE domain protein, interacts with Smad4 and facilitates transforming growth factor-beta signaling.". J. Biol. Chem. 282 (13): 9688–95. doi:10.1074/jbc.M611704200. PMID 17272273.
Chen Y, Low TY, Choong LY, et al. (2007). "Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells.". Proteomics 7 (14): 2384–97. doi:10.1002/pmic.200600968. PMID 17570516.