ZFPM1

From Wikipedia, the free encyclopedia

Zinc finger protein, multitype 1

PDB rendering based on 1srk.

Available structures: 1srk

Identifiers

Symbol(s)

ZFPM1; ZNF408; FOG; FOG1; ZNF89A

External IDs

OMIM: 601950 MGI: 1095400 HomoloGene: 7606

Gene ontology
Molecular Function:	• DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • heart development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_153813 (mRNA)
NP_722520 (protein)

XM_001001818 (mRNA)
XP_001001818 (protein)

Location

Chr 16: 87.05 - 87.13 Mb

Chr 8: 125.17 - 125.22 Mb

Pubmed search

[1]

[2]

Zinc finger protein, multitype 1, also known as ZFPM1, is a human gene.^[1]

[edit] References

^ Entrez Gene: ZFPM1 zinc finger protein, multitype 1.

[edit] Further reading

Tsang AP, Visvader JE, Turner CA, et al. (1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation.". Cell 90 (1): 109-19. PMID 9230307.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129-40. doi:10.1093/emboj/17.17.5129. PMID 9724649.
Mehaffey MG, Newton AL, Gandhi MJ, et al. (2001). "X-linked thrombocytopenia caused by a novel mutation of GATA-1.". Blood 98 (9): 2681-8. PMID 11675338.
Yu C, Niakan KK, Matsushita M, et al. (2002). "X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction.". Blood 100 (6): 2040-5. doi:10.1182/blood-2002-02-0387. PMID 12200364.
Freson K, Thys C, Wittewrongel C, et al. (2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins carrying D218 substitutions.". Hum. Genet. 112 (1): 42-9. doi:10.1007/s00439-002-0832-1. PMID 12483298.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935.
Liew CK, Simpson RJ, Kwan AH, et al. (2005). "Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.". Proc. Natl. Acad. Sci. U.S.A. 102 (3): 583-8. doi:10.1073/pnas.0407511102. PMID 15644435.
Vannucchi AM, Pancrazzi A, Guglielmelli P, et al. (2005). "Abnormalities of GATA-1 in megakaryocytes from patients with idiopathic myelofibrosis.". Am. J. Pathol. 167 (3): 849-58. PMID 16127162.
Yang HY, Kim SH, Kim SH, et al. (2007). "The suppression of zfpm-1 accelerates the erythropoietic differentiation of human CD34+ cells.". Biochem. Biophys. Res. Commun. 353 (4): 978-84. doi:10.1016/j.bbrc.2006.12.155. PMID 17207461.