ZFP36

From Wikipedia, the free encyclopedia

Zinc finger protein 36, C3H type, homolog (mouse)

PDB rendering based on 1m9o.

Available structures: 1m9o

Identifiers

Symbol(s)

ZFP36; G0S24; GOS24; NUP475; RNF162A; TIS11; TTP

External IDs

OMIM: 190700 MGI: 99180 HomoloGene: 2558

Gene ontology
Molecular Function:	• DNA binding • single-stranded RNA binding • mRNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm • cytosol
Biological Process:	• mRNA catabolic process • protein kinase cascade • regulation of mRNA stability • negative regulation of myeloid cell differentiation • negative regulation of inflammatory response • RNA destabilization

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003407 (mRNA)
NP_003398 (protein)

NM_011756 (mRNA)
NP_035886 (protein)

Location

Chr 19: 44.59 - 44.59 Mb

Chr 7: 28.09 - 28.09 Mb

Pubmed search

[1]

[2]

Zinc finger protein 36, C3H type, homolog (mouse), also known as ZFP36, is a human gene.^[1]

[edit] References

^ Entrez Gene: ZFP36 zinc finger protein 36, C3H type, homolog (mouse).

[edit] Further reading

Blackshear PJ (2003). "Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover.". Biochem. Soc. Trans. 30 (Pt 6): 945-52. doi:10.1042/. PMID 12440952.
Carrick DM, Lai WS, Blackshear PJ (2005). "The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis.". Arthritis Res. Ther. 6 (6): 248-64. doi:10.1186/ar1441. PMID 15535838.
Makar AB, McMartin KE, Palese M, Tephly TR (1976). "Formate assay in body fluids: application in methanol poisoning.". Biochemical medicine 13 (2): 117-26. PMID 1.
DuBois RN, McLane MW, Ryder K, et al. (1990). "A growth factor-inducible nuclear protein with a novel cysteine/histidine repetitive sequence.". J. Biol. Chem. 265 (31): 19185-91. PMID 1699942.
Taylor GA, Lai WS, Oakey RJ, et al. (1991). "The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes.". Nucleic Acids Res. 19 (12): 3454. PMID 2062660.
Lai WS, Stumpo DJ, Blackshear PJ (1990). "Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein.". J. Biol. Chem. 265 (27): 16556-63. PMID 2204625.
Taylor GA, Thompson MJ, Lai WS, Blackshear PJ (1995). "Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro.". J. Biol. Chem. 270 (22): 13341-7. PMID 7768935.
Heximer SP, Forsdyke DR (1993). "A human putative lymphocyte G0/G1 switch gene homologous to a rodent gene encoding a zinc-binding potential transcription factor.". DNA Cell Biol. 12 (1): 73-88. PMID 8422274.
Huebner K, Druck T, LaForgia S, et al. (1993). "Chromosomal localization of four human zinc finger cDNAs.". Hum. Genet. 91 (3): 217-22. PMID 8478004.
Carballo E, Lai WS, Blackshear PJ (1998). "Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin.". Science 281 (5379): 1001-5. PMID 9703499.
Lai WS, Carballo E, Thorn JM, et al. (2000). "Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA.". J. Biol. Chem. 275 (23): 17827-37. doi:10.1074/jbc.M001696200. PMID 10751406.
Dintilhac A, Bernués J (2002). "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021-8. doi:10.1074/jbc.M108417200. PMID 11748221.
Lai WS, Kennington EA, Blackshear PJ (2002). "Interactions of CCCH zinc finger proteins with mRNA: non-binding tristetraprolin mutants exert an inhibitory effect on degradation of AU-rich element-containing mRNAs.". J. Biol. Chem. 277 (11): 9606-13. doi:10.1074/jbc.M110395200. PMID 11782475.
Johnson BA, Stehn JR, Yaffe MB, Blackwell TK (2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.". J. Biol. Chem. 277 (20): 18029-36. doi:10.1074/jbc.M110465200. PMID 11886850.
Brooks SA, Connolly JE, Diegel RJ, et al. (2002). "Analysis of the function, expression, and subcellular distribution of human tristetraprolin.". Arthritis Rheum. 46 (5): 1362-70. doi:10.1002/art.10235. PMID 12115244.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Amann BT, Worthington MT, Berg JM (2003). "A Cys3His zinc-binding domain from Nup475/tristetraprolin: a novel fold with a disklike structure.". Biochemistry 42 (1): 217-21. doi:10.1021/bi026988m. PMID 12515557.
Yu H, Stasinopoulos S, Leedman P, Medcalf RL (2003). "Inherent instability of plasminogen activator inhibitor type 2 mRNA is regulated by tristetraprolin.". J. Biol. Chem. 278 (16): 13912-8. doi:10.1074/jbc.M213027200. PMID 12578825.
Sawaoka H, Dixon DA, Oates JA, Boutaud O (2003). "Tristetraprolin binds to the 3'-untranslated region of cyclooxygenase-2 mRNA. A polyadenylation variant in a cancer cell line lacks the binding site.". J. Biol. Chem. 278 (16): 13928-35. doi:10.1074/jbc.M300016200. PMID 12578839.