ZFP36L1

From Wikipedia, the free encyclopedia

Zinc finger protein 36, C3H type-like 1

PDB rendering based on 1rgo.

Available structures: 1rgo

Identifiers

Symbol(s)

ZFP36L1; BRF1; Berg36; ERF-1; ERF1; RNF162B; TIS11B; cMG1

External IDs

OMIM: 601064 MGI: 107946 HomoloGene: 31276

Gene ontology
Molecular Function:	• transcription factor activity • mRNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• regulation of mRNA stability

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004926 (mRNA)
NP_004917 (protein)

NM_007564 (mRNA)
NP_031590 (protein)

Location

Chr 14: 68.33 - 68.33 Mb

Chr 12: 81.03 - 81.03 Mb

Pubmed search

[1]

[2]

Zinc finger protein 36, C3H type-like 1, also known as ZFP36L1, is a human gene.^[1]

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZFP36L1 zinc finger protein 36, C3H type-like 1.

[edit] Further reading

Bustin SA, Nie XF, Barnard RC, et al. (1994). "Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.". DNA Cell Biol. 13 (5): 449-59. PMID 8024689.
Barnard RC, Pascall JC, Brown KD, et al. (1993). "Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes.". Nucleic Acids Res. 21 (15): 3580. PMID 8346037.
Maclean KN, See CG, McKay IA, Bustin SA (1996). "The human immediate early gene BRF1 maps to chromosome 14q22-q24.". Genomics 30 (1): 89-90. doi:10.1006/geno.1995.0014. PMID 8595910.
Ning ZQ, Norton JD, Li J, Murphy JJ (1996). "Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.". Eur. J. Immunol. 26 (10): 2356-63. PMID 8898945.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Blackshear PJ, Phillips RS, Vazquez-Matias J, Mohrenweiser H (2004). "Polymorphisms in the genes encoding members of the tristetraprolin family of human tandem CCCH zinc finger proteins.". Prog. Nucleic Acid Res. Mol. Biol. 75: 43-68. PMID 14604009.
Reppe S, Olstad OK, Rian E, et al. (2004). "Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells.". Biochem. Biophys. Res. Commun. 324 (1): 218-23. doi:10.1016/j.bbrc.2004.09.030. PMID 15465005.
Ciais D, Cherradi N, Bailly S, et al. (2004). "Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b.". Oncogene 23 (53): 8673-80. doi:10.1038/sj.onc.1207939. PMID 15467755.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.