ZEB1

From Wikipedia, the free encyclopedia

Zinc finger E-box binding homeobox 1

PDB rendering based on 2e19.

Available structures: 2e19

Identifiers

Symbol(s)

ZEB1; AREB6; BZP; MGC133261; NIL-2-A; NIL-2A; TCF8; ZEB; ZFHEP; ZFHX1A

External IDs

OMIM: 189909 MGI: 1344313 HomoloGene: 31779

Gene ontology
Molecular Function:	• nucleic acid binding • transcription factor activity • transcription coactivator activity • transcription corepressor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • transcription • regulation of transcription, DNA-dependent • immune response • central nervous system development • cell proliferation • embryonic morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030751 (mRNA)
NP_110378 (protein)

NM_011546 (mRNA)
NP_035676 (protein)

Location

Chr 10: 31.65 - 31.86 Mb

Chr 18: 5.59 - 5.77 Mb

Pubmed search

[1]

[2]

Zinc finger E-box binding homeobox 1, also known as ZEB1, is a human gene.^[1]

TCF8 encodes a human zinc finger transcription factor that represses T-lymphocyte-specific IL2 gene (MIM 147680) expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 transcription start site (Williams et al., 1991).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ZEB1 zinc finger E-box binding homeobox 1.

[edit] Further reading

Williams TM, Montoya G, Wu Y, et al. (1992). "The TCF8 gene encoding a zinc finger protein (Nil-2-a) resides on human chromosome 10p11.2.". Genomics 14 (1): 194–6. PMID 1427828.
Williams TM, Moolten D, Burlein J, et al. (1992). "Identification of a zinc finger protein that inhibits IL-2 gene expression.". Science 254 (5039): 1791–4. PMID 1840704.
Franklin AJ, Jetton TL, Shelton KD, Magnuson MA (1994). "BZP, a novel serum-responsive zinc finger protein that inhibits gene transcription.". Mol. Cell. Biol. 14 (10): 6773–88. PMID 7935395.
Watanabe Y, Kawakami K, Hirayama Y, Nagano K (1994). "Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene.". J. Biochem. 114 (6): 849–55. PMID 8138542.
Ikeda K, Halle JP, Stelzer G, et al. (1998). "Involvement of negative cofactor NC2 in active repression by zinc finger-homeodomain transcription factor AREB6.". Mol. Cell. Biol. 18 (1): 10–8. PMID 9418848.
Turner J, Crossley M (1998). "Cloning and characterization of mCtBP2, a co-repressor that associates with basic Krüppel-like factor and other mammalian transcriptional regulators.". EMBO J. 17 (17): 5129–40. doi:10.1093/emboj/17.17.5129. PMID 9724649.
Postigo AA, Dean DC (1999). "ZEB represses transcription through interaction with the corepressor CtBP.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6683–8. PMID 10359772.
Hlubek F, Löhberg C, Meiler J, et al. (2001). "Tip60 is a cell-type-specific transcriptional regulator.". J. Biochem. 129 (4): 635–41. PMID 11275565.
Locklin RM, Riggs BL, Hicok KC, et al. (2002). "Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology.". J. Bone Miner. Res. 16 (12): 2192–204. PMID 11760832.
Shaheduzzaman S, Krishnan V, Petrovic A, et al. (2002). "Effects of HIV-1 Nef on cellular gene expression profiles.". J. Biomed. Sci. 9 (1): 82–96. PMID 11810028.
Guaita S, Puig I, Franci C, et al. (2002). "Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression.". J. Biol. Chem. 277 (42): 39209–16. doi:10.1074/jbc.M206400200. PMID 12161443.
Costantino ME, Stearman RP, Smith GE, Darling DS (2002). "Cell-specific phosphorylation of Zfhep transcription factor.". Biochem. Biophys. Res. Commun. 296 (2): 368–73. PMID 12163027.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Postigo AA (2003). "Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway.". EMBO J. 22 (10): 2443–52. doi:10.1093/emboj/cdg225. PMID 12743038.
Postigo AA, Depp JL, Taylor JJ, Kroll KL (2003). "Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins.". EMBO J. 22 (10): 2453–62. doi:10.1093/emboj/cdg226. PMID 12743039.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dillner NB, Sanders MM (2004). "Transcriptional activation by the zinc-finger homeodomain protein delta EF1 in estrogen signaling cascades.". DNA Cell Biol. 23 (1): 25–34. doi:10.1089/104454904322745907. PMID 14965470.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Shimizu S, Krafchak C, Fuse N, et al. (2005). "A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10.". Am. J. Med. Genet. A 130 (4): 372–7. doi:10.1002/ajmg.a.30267. PMID 15384081.
Eger A, Aigner K, Sonderegger S, et al. (2005). "DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.". Oncogene 24 (14): 2375–85. doi:10.1038/sj.onc.1208429. PMID 15674322.