ZDHHC8

From Wikipedia, the free encyclopedia

Zinc finger, DHHC-type containing 8

Identifiers

ZDHHC8; ZDHHCL1; ZNF378

External IDs

OMIM: 608784 MGI: 1338012 HomoloGene: 8363

Gene ontology
Molecular Function:	• zinc ion binding • acyltransferase activity • transferase activity • metal ion binding
Cellular Component:	• membrane • integral to membrane

Orthologs

Human

Mouse

Refseq

NM_013373 (mRNA)
NP_037505 (protein)

XM_985512 (mRNA)
XP_990606 (protein)

Location

Chr 22: 18.5 - 18.52 Mb

Chr 16: 18.13 - 18.15 Mb

Pubmed search

[1]

[2]

Zinc finger, DHHC-type containing 8, also known as ZDHHC8, is a human gene.^[1]

[edit] References

^ Entrez Gene: ZDHHC8 zinc finger, DHHC-type containing 8.

[edit] Further reading

Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (5): 337–45. PMID 10574462.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Mukai J, Liu H, Burt RA, et al. (2004). "Evidence that the gene encoding ZDHHC8 contributes to the risk of schizophrenia.". Nat. Genet. 36 (7): 725–31. doi:10.1038/ng1375. PMID 15184899.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
Chen WY, Shi YY, Zheng YL, et al. (2005). "Case-control study and transmission disequilibrium test provide consistent evidence for association between schizophrenia and genetic variation in the 22q11 gene ZDHHC8.". Hum. Mol. Genet. 13 (23): 2991–5. doi:10.1093/hmg/ddh322. PMID 15489219.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Saito S, Ikeda M, Iwata N, et al. (2005). "No association was found between a functional SNP in ZDHHC8 and schizophrenia in a Japanese case-control population.". Neurosci. Lett. 374 (1): 21–4. doi:10.1016/j.neulet.2004.10.015. PMID 15631889.
Glaser B, Schumacher J, Williams HJ, et al. (2005). "No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.". Biol. Psychiatry 58 (1): 78–80. doi:10.1016/j.biopsych.2005.03.017. PMID 15992527.
Otani K, Ujike H, Tanaka Y, et al. (2006). "The ZDHHC8 gene did not associate with bipolar disorder or schizophrenia.". Neurosci. Lett. 390 (3): 166–70. doi:10.1016/j.neulet.2005.08.019. PMID 16150541.
Demily C, Legallic S, Bou J, et al. (2007). "ZDHHC8 single nucleotide polymorphism rs175174 is not associated with psychiatric features of the 22q11 deletion syndrome or schizophrenia.". Psychiatr. Genet. 17 (5): 311–2. doi:10.1097/YPG.0b013e328133f369. PMID 17728672.