ZC3HAV1

From Wikipedia, the free encyclopedia

Zinc finger CCCH-type, antiviral 1

Identifiers

ZC3HAV1; ZAP; DKFZp686F2052; DKFZp686H1869; DKFZp686O19171; FLB6421; FLJ13288; MGC48898; ZC3H2; ZC3HDC2

External IDs

OMIM: 607312 MGI: 1926031 HomoloGene: 10585

Gene ontology
Molecular Function:	• nucleic acid binding • NAD+ ADP-ribosyltransferase activity • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• protein amino acid ADP-ribosylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_020119 (mRNA)
NP_064504 (protein)

NM_028864 (mRNA)
NP_083140 (protein)

Location

Chr 7: 138.38 - 138.45 Mb

Chr 6: 38.24 - 38.28 Mb

Pubmed search

[1]

[2]

Zinc finger CCCH-type, antiviral 1, also known as ZC3HAV1, is a human gene.^[1]

This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral infection. Alternative splicing occurs at this locus and two variants, each encoding distinct isoforms, are described.^[1]

[edit] References

^ ^a ^b Entrez Gene: ZC3HAV1 zinc finger CCCH-type, antiviral 1.

[edit] Further reading

Yu Y, Zhang C, Zhou G, et al. (2001). "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs.". Genome Res. 11 (8): 1392–403. doi:10.1101/gr.175501. PMID 11483580.
Gao G, Guo X, Goff SP (2002). "Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein.". Science 297 (5587): 1703–6. doi:10.1126/science.1074276. PMID 12215647.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Katoh M, Katoh M (2004). "Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31.". Int. J. Oncol. 23 (2): 541–7. PMID 12851707.
Bick MJ, Carroll JW, Gao G, et al. (2003). "Expression of the zinc-finger antiviral protein inhibits alphavirus replication.". J. Virol. 77 (21): 11555–62. PMID 14557641.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
MacDonald MR, Machlin ES, Albin OR, Levy DE (2007). "The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses.". J. Virol. 81 (24): 13509–18. doi:10.1128/JVI.00402-07. PMID 17928353.