ZBP1

From Wikipedia, the free encyclopedia

Z-DNA binding protein 1

Identifiers

ZBP1; C20orf183; DLM-1; DLM1

External IDs

OMIM: 606750 MGI: 1927449 HomoloGene: 10972

Gene ontology
Molecular Function:	• DNA binding • left-handed Z-DNA binding • RNA binding • double-stranded RNA adenosine deaminase activity
Cellular Component:	• cellular_component
Biological Process:	• biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030776 (mRNA)
NP_110403 (protein)

NM_021394 (mRNA)
NP_067369 (protein)

Location

Chr 20: 55.6 - 55.63 Mb

Chr 2: 172.85 - 172.86 Mb

Pubmed search

[1]

[2]

Z-DNA binding protein 1, also known as ZBP1, is a human gene.^[1]

DLM1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: ZBP1 Z-DNA binding protein 1.

[edit] Further reading

Ha SC, Van Quyen D, Hwang HY, et al. (2006). "Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA.". Biochim. Biophys. Acta 1764 (2): 320-3. doi:10.1016/j.bbapap.2005.12.012. PMID 16448869.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Rothenburg S, Schwartz T, Koch-Nolte F, Haag F (2002). "Complex regulation of the human gene for the Z-DNA binding protein DLM-1.". Nucleic Acids Res. 30 (4): 993-1000. PMID 11842111.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052.
Schwartz T, Behlke J, Lowenhaupt K, et al. (2001). "Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins.". Nat. Struct. Biol. 8 (9): 761-5. doi:10.1038/nsb0901-761. PMID 11524677.
Schwartz T, Rould MA, Lowenhaupt K, et al. (1999). "Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.". Science 284 (5421): 1841-5. PMID 10364558.