Talk:Zalcitabine

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I've overhauled this page. Some points which aren't immediately obvious:

• The statement on potency compared with other antiretrovirals isn't supported by the major clinical trials of ddC, where there's no statistically significant difference between the ddC arms and the other nRTI arms. See eg Moyle 1998 for a review. The major reasons why ddC isn't used are the high frequency of peripheral neuropathy and the tid frequency.

• I'm not sure where the "only use with ZDV" statement originated; I can find no evidence for this. I've recast this to say "don't use with ZDV, ddI, d4T", as it states in the latest tx guidelines.

Espresso Addict 14:48, 18 May 2006 (UTC)