Talk:Z-factor

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Mathematics rating:	Start Class	Low Priority	Field: Probability and statistics
Please update this rating as the article progresses, or if the rating is inaccurate. Click to show/hide comments. Please add to or update the comments to suggest improvements to the article. Geometry guy 17:17, 2 June 2007 (UTC)

There is a z-factor for real gas compressibility which expresses the deviation from ideal behaviour of a gas when compressed. The Ideal gas formula P.V=n.R.T is reformulated to P.V=z.n.R.T where z is a variable dependant on the gas and the pressure. Several equations have been proposed for the calculation of z.

[edit] contact this person for expert advice

You say that this article requires expert attention. I suggest you contact zwu@stat.brown.edu since he / she has published on this topic. See Journal of Biomolecular Screening vol 12, page 229 (1997)

Abstract is free to all and is quoted here:

High-throughput screening is an essential process in drug discovery. The ability to identify true active compounds depends on the high quality of assays and proper analysis of data. The Z factor, presented by Zhang et al. in 1999, provides an easy and useful summary of assay quality and has been a widely accepted standard. However, as data analysis has undergone much improvement recently, the assessment of assay quality has not evolved in parallel. In this article, the authors study the implications of Z factor values under different conditions and link the Z factor with the power of discovering true active compounds. They discuss the different interpretations of Z factor depending on error distributions and advocate direct analysis of power as assay quality assessment. They also propose that in estimating assay quality parameters, adjustments in data analysis should be taken into account. Studying the power of identifying true “hits” gives a more direct interpretation of assay quality and may provide guidance in assay optimization on some occasions. (Journal of Biomolecular Screening 2007:229-234)