YWHAZ

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Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
PDB rendering based on 1a37.
Available structures: 1a37, 1a38, 1a4o, 1ib1, 1qja, 1qjb, 2c1j, 2c1n
Identifiers
Symbol(s) YWHAZ; KCIP-1; MGC111427; MGC126532; MGC138156
External IDs OMIM: 601288 MGI: 109484 HomoloGene: 56528
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7534 22631
Ensembl ENSG00000164924 ENSMUSG00000022285
Uniprot P63104 Q3UA58
Refseq NM_003406 (mRNA)
NP_003397 (protein)		 NM_011740 (mRNA)
NP_035870 (protein)
Location Chr 8: 102 - 102.03 Mb Chr 15: 36.72 - 36.74 Mb
Pubmed search [1] [2]

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide, also known as YWHAZ, is a human gene.

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.[1]

[edit] See also

[edit] References

  1. ^ Entrez Gene: YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide.

[edit] Further reading

  • Kino T, Pavlakis GN (2004). "Partner molecules of accessory protein Vpr of the human immunodeficiency virus type 1.". DNA Cell Biol. 23 (4): 193–205. doi:10.1089/104454904773819789. PMID 15142377. 
  • Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780. 
  • Calinisan V, Gravem D, Chen RP, et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.". Front. Biosci. 11: 1646–66. PMID 16368544. 
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