YWHAQ

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Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
PDB rendering based on 2btp.
Available structures: 2btp
Identifiers
Symbol(s) YWHAQ; HS1; 14-3-3; 1C5
External IDs OMIM: 609009 MGI: 891963 HomoloGene: 48407
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10971 22630
Ensembl ENSG00000134308 n/a
Uniprot P27348 n/a
Refseq NM_006826 (mRNA)
NP_006817 (protein)		 NM_011739 (mRNA)
NP_035869 (protein)
Location Chr 2: 9.64 - 9.69 Mb n/a
Pubmed search [1] [2]

Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide, also known as YWHAQ, is a human gene.

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.[1]

[edit] References

  1. ^ Entrez Gene: YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide.

[edit] Further reading

  • Kino T, Chrousos GP (2004). "Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS-related insulin resistance/lipodystrophy syndrome?". Ann. N. Y. Acad. Sci. 1024: 153–67. doi:10.1196/annals.1321.013. PMID 15265780. 
  • Calinisan V, Gravem D, Chen RP, et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.". Front. Biosci. 11: 1646–66. PMID 16368544. 
  • Nielsen PJ (1991). "Primary structure of a human protein kinase regulator protein.". Biochim. Biophys. Acta 1088 (3): 425–8. PMID 2015305. 
  • Bonnefoy-Bérard N, Liu YC, von Willebrand M, et al. (1995). "Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10142–6. PMID 7479742. 
  • Xiao B, Smerdon SJ, Jones DH, et al. (1995). "Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways.". Nature 376 (6536): 188–91. doi:10.1038/376188a0. PMID 7603573. 
  • Leffers H, Madsen P, Rasmussen HH, et al. (1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.". J. Mol. Biol. 231 (4): 982–98. doi:10.1006/jmbi.1993.1346. PMID 8515476. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Liu YC, Elly C, Yoshida H, et al. (1996). "Activation-modulated association of 14-3-3 proteins with Cbl in T cells.". J. Biol. Chem. 271 (24): 14591–5. PMID 8663231. 
  • Papin C, Denouel A, Calothy G, Eychène A (1996). "Identification of signalling proteins interacting with B-Raf in the yeast two-hybrid system.". Oncogene 12 (10): 2213–21. PMID 8668348. 
  • Zha J, Harada H, Yang E, et al. (1997). "Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)". Cell 87 (4): 619–28. PMID 8929531. 
  • Suzuki Y, Demoliere C, Kitamura D, et al. (1997). "HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases.". J. Immunol. 158 (6): 2736–44. PMID 9058808. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174. 
  • Dubois T, Rommel C, Howell S, et al. (1997). "14-3-3 is phosphorylated by casein kinase I on residue 233. Phosphorylation at this site in vivo regulates Raf/14-3-3 interaction.". J. Biol. Chem. 272 (46): 28882–8. PMID 9360956. 
  • Hsu SY, Kaipia A, Zhu L, Hsueh AJ (1997). "Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11.". Mol. Endocrinol. 11 (12): 1858–67. PMID 9369453. 
  • Brunati AM, Donella-Deana A, James P, et al. (1999). "Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase.". J. Biol. Chem. 274 (11): 7557–64. PMID 10066823. 
  • Hausser A, Storz P, Link G, et al. (1999). "Protein kinase C mu is negatively regulated by 14-3-3 signal transduction proteins.". J. Biol. Chem. 274 (14): 9258–64. PMID 10092600. 
  • Finlin BS, Andres DA (1999). "Phosphorylation-dependent association of the Ras-related GTP-binding protein Rem with 14-3-3 proteins.". Arch. Biochem. Biophys. 368 (2): 401–12. doi:10.1006/abbi.1999.1316. PMID 10441394. 
  • Chow CW, Davis RJ (2000). "Integration of calcium and cyclic AMP signaling pathways by 14-3-3.". Mol. Cell. Biol. 20 (2): 702–12. PMID 10611249. 
  • Mori H, Inoue M, Yano M, et al. (2000). "14-3-3tau associates with a translational control factor FKBP12-rapamycin-associated protein in T-cells after stimulation by pervanadate.". FEBS Lett. 467 (1): 61–4. PMID 10664457. 
  • Mils V, Baldin V, Goubin F, et al. (2000). "Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase.". Oncogene 19 (10): 1257–65. doi:10.1038/sj.onc.1203419. PMID 10713667. 
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.