YKT6

From Wikipedia, the free encyclopedia

YKT6 v-SNARE homolog (S. cerevisiae)

Identifiers

External IDs

OMIM: 606209 MGI: 1927550 HomoloGene: 4778

Gene ontology
Molecular Function:	• SNAP receptor activity • protein-cysteine S-palmitoleyltransferase activity
Cellular Component:	• endoplasmic reticulum • integral to plasma membrane
Biological Process:	• ER to Golgi vesicle-mediated transport • vesicle targeting • vesicle docking during exocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006555 (mRNA)
NP_006546 (protein)

NM_019661 (mRNA)
NP_062635 (protein)

Location

Chr 7: 44.21 - 44.22 Mb

Chr 11: 5.86 - 5.87 Mb

Pubmed search

[1]

[2]

YKT6 v-SNARE homolog (S. cerevisiae), also known as YKT6, is a human gene.^[1]

This gene product is one of the SNARE recognition molecules implicated in vesicular transport between secretory compartments. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. This protein is highly conserved from yeast to human and can functionally complement the loss of the yeast homolog in the yeast secretory pathway.^[1]

[edit] References

^ ^a ^b Entrez Gene: YKT6 YKT6 v-SNARE homolog (S. cerevisiae).

[edit] Further reading

Rossi V, Banfield DK, Vacca M, et al. (2005). "Longins and their longin domains: regulated SNAREs and multifunctional SNARE regulators.". Trends Biochem. Sci. 29 (12): 682–8. doi:10.1016/j.tibs.2004.10.002. PMID 15544955.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
McNew JA, Sogaard M, Lampen NM, et al. (1997). "Ykt6p, a prenylated SNARE essential for endoplasmic reticulum-Golgi transport.". J. Biol. Chem. 272 (28): 17776–83. PMID 9211930.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Tochio H, Tsui MM, Banfield DK, Zhang M (2001). "An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p.". Science 293 (5530): 698–702. doi:10.1126/science.1062950. PMID 11474112.
Honer WG, Falkai P, Bayer TA, et al. (2002). "Abnormalities of SNARE mechanism proteins in anterior frontal cortex in severe mental illness.". Cereb. Cortex 12 (4): 349–56. PMID 11884350.
Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603.
Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.". Mol. Biol. Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMID 12388752.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Puri N, Kruhlak MJ, Whiteheart SW, Roche PA (2004). "Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly.". J. Immunol. 171 (10): 5345–52. PMID 14607937.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Fukasawa M, Varlamov O, Eng WS, et al. (2004). "Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation.". Proc. Natl. Acad. Sci. U.S.A. 101 (14): 4815–20. doi:10.1073/pnas.0401183101. PMID 15044687.
Tai G, Lu L, Wang TL, et al. (2005). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network.". Mol. Biol. Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMID 15215310.
Veit M (2005). "The human SNARE protein Ykt6 mediates its own palmitoylation at C-terminal cysteine residues.". Biochem. J. 384 (Pt 2): 233–7. doi:10.1042/BJ20041474. PMID 15479160.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Okumura AJ, Hatsuzawa K, Tamura T, et al. (2006). "Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system.". J. Biol. Chem. 281 (7): 4495–506. doi:10.1074/jbc.M509715200. PMID 16354670.
Ooe A, Kato K, Noguchi S (2007). "Possible involvement of CCT5, RGS3, and YKT6 genes up-regulated in p53-mutated tumors in resistance to docetaxel in human breast cancers.". Breast Cancer Res. Treat. 101 (3): 305–15. doi:10.1007/s10549-006-9293-x. PMID 16821082.