YES1

From Wikipedia, the free encyclopedia

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

PDB rendering based on 2hda.

Available structures: 2hda, 2hwo, 2hwp, 2oiq

Identifiers

Symbol(s)

YES1; HsT441; P61-YES; Yes; c-yes

External IDs

OMIM: 164880 MGI: 99147 HomoloGene: 55900

Gene ontology
Molecular Function:	• nucleotide binding • protein-tyrosine kinase activity • protein binding • ATP binding • transferase activity
Biological Process:	• protein amino acid phosphorylation • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005433 (mRNA)
NP_005424 (protein)

NM_009535 (mRNA)
NP_033561 (protein)

Location

Chr 18: 0.71 - 0.8 Mb

Chr 5: 32.89 - 32.96 Mb

Pubmed search

[1]

[2]

V-yes-1 Yamaguchi sarcoma viral oncogene homolog 1, also known as YES1, is a human gene.^[1]

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.^[1]

[edit] References

^ ^a ^b Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1.

[edit] Further reading

Brickell PM (1992). "The p60c-src family of protein-tyrosine kinases: structure, regulation, and function.". Critical reviews in oncogenesis 3 (4): 401–46. PMID 1384720.
Toyoshima K, Semba K, Nishizawa M, et al. (1988). "Nakahara memorial lecture. Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family.". Int. Symp. Princess Takamatsu Cancer Res. Fund 17: 11–20. PMID 3332005.
Sudol M, Chen HI, Bougeret C, et al. (1995). "Characterization of a novel protein-binding module--the WW domain.". FEBS Lett. 369 (1): 67–71. PMID 7641887.
Summy JM, Sudol M, Eck MJ, et al. (2004). "Specificity in signaling by c-Yes.". Front. Biosci. 8: s185–205. PMID 12456296.
Cichowski K, McCormick F, Brugge JS (1992). "p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets.". J. Biol. Chem. 267 (8): 5025–8. PMID 1544885.
Huang MM, Bolen JB, Barnwell JW, et al. (1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets.". Proc. Natl. Acad. Sci. U.S.A. 88 (17): 7844–8. PMID 1715582.
Holtrich U, Bräuninger A, Strebhardt K, Rübsamen-Waigmann H (1992). "Two additional protein-tyrosine kinases expressed in human lung: fourth member of the fibroblast growth factor receptor family and an intracellular protein-tyrosine kinase.". Proc. Natl. Acad. Sci. U.S.A. 88 (23): 10411–5. PMID 1720539.
Krueger J, Zhao YH, Murphy D, Sudol M (1991). "Differential expression of p62c-yes in normal, hyperplastic and neoplastic human epidermis.". Oncogene 6 (6): 933–40. PMID 2067846.
Zhao YH, Krueger JG, Sudol M (1991). "Expression of cellular-yes protein in mammalian tissues.". Oncogene 5 (11): 1629–35. PMID 2267131.
Sukegawa J, Semba K, Yamanashi Y, et al. (1987). "Characterization of cDNA clones for the human c-yes gene.". Mol. Cell. Biol. 7 (1): 41–7. PMID 2436037.
Semba K, Yamanashi Y, Nishizawa M, et al. (1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues.". Science 227 (4690): 1038–40. PMID 2983418.
Bull HA, Brickell PM, Dowd PM (1994). "Src-related protein tyrosine kinases are physically associated with the surface antigen CD36 in human dermal microvascular endothelial cells.". FEBS Lett. 351 (1): 41–4. PMID 7521304.
Toshima J, Ohashi K, Iwashita S, Mizuno K (1995). "Autophosphorylation activity and association with Src family kinase of Sky receptor tyrosine kinase.". Biochem. Biophys. Res. Commun. 209 (2): 656–63. doi:10.1006/bbrc.1995.1549. PMID 7537495.
Courtneidge SA, Dhand R, Pilat D, et al. (1993). "Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.". EMBO J. 12 (3): 943–50. PMID 7681396.
Mori S, Rönnstrand L, Yokote K, et al. (1993). "Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases.". EMBO J. 12 (6): 2257–64. PMID 7685273.
Waltenberger J, Claesson-Welsh L, Siegbahn A, et al. (1994). "Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.". J. Biol. Chem. 269 (43): 26988–95. PMID 7929439.
Silverman GA, Kuo WL, Taillon-Miller P, Gray JW (1993). "Chromosomal reassignment: YACs containing both YES1 and thymidylate synthase map to the short arm of chromosome 18.". Genomics 15 (2): 442–5. doi:10.1006/geno.1993.1086. PMID 8449516.