Yeast U1 spliceosomal RNA

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Yeast U1 spliceosomal RNA

Type:	Gene; snRNA; splicing;
2° structure:	Published; PubMed
Seed alignment:	Zwieb C, The uRNA database, PubMed
Avg length:	553.2 nucleotides
Avg identity:	61%

U1 is a small nuclear RNA (snRNA) component of the spliceosome and is involved in pre-mRNA splicing.

In the splicing process the 5' end of the U1 snRNA forms complementary base pairing with the 5' splice junction of the inton to be excised, thus defining the 5' donor site of an intron.

There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV ^[1]^[2]. The secondary structure model shows the structure prediction for the larger yeast sequences.

[edit] References

^ Zwieb C (1997). "The uRNA database". Nucleic Acids Res. 25 (1): 102–3. PMID 9016512.
^ Kretzner L, Krol A, Rosbash M (1990). "Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 851–5. PMID 2405391.