YAP1

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Yes-associated protein 1, 65kDa
PDB rendering based on 1jmq.
Available structures: 1jmq, 1k5r, 1k9q, 1k9r
Identifiers
Symbol(s) YAP1; YAP; YAP2; YAP65
External IDs OMIM: 606608 MGI: 103262 HomoloGene: 4452
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10413 22601
Ensembl ENSG00000137693 ENSMUSG00000053110
Uniprot P46937 Q3TUW1
Refseq NM_006106 (mRNA)
NP_006097 (protein)		 NM_009534 (mRNA)
NP_033560 (protein)
Location Chr 11: 101.49 - 101.61 Mb Chr 9: 7.94 - 8.01 Mb
Pubmed search [1] [2]

Yes-associated protein 1, 65kDa, also known as YAP1, is a human gene.[1]

This gene encodes the human ortholog of chicken YAP protein which binds to the SH3 domain of the Yes proto-oncogene product. This protein contains a WW domain that is found in various structural, regulatory and signaling molecules in yeast, nematode, and mammals, and may be involved in protein-protein interaction.[1]

[edit] References

  1. ^ a b Entrez Gene: YAP1 Yes-associated protein 1, 65kDa.

[edit] Further reading

  • Sudol M, Chen HI, Bougeret C, et al. (1995). "Characterization of a novel protein-binding module--the WW domain.". FEBS Lett. 369 (1): 67–71. PMID 7641887. 
  • Chen HI, Sudol M (1995). "The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7819–23. PMID 7644498. 
  • Sudol M, Bork P, Einbond A, et al. (1995). "Characterization of the mammalian YAP (Yes-associated protein) gene and its role in defining a novel protein module, the WW domain.". J. Biol. Chem. 270 (24): 14733–41. PMID 7782338. 
  • Chen HI, Einbond A, Kwak SJ, et al. (1997). "Characterization of the WW domain of human yes-associated protein and its polyproline-containing ligands.". J. Biol. Chem. 272 (27): 17070–7. PMID 9202023. 
  • Gavva NR, Gavva R, Ermekova K, et al. (1997). "Interaction of WW domains with hematopoietic transcription factor p45/NF-E2 and RNA polymerase II.". J. Biol. Chem. 272 (39): 24105–8. PMID 9305852. 
  • Yagi R, Chen LF, Shigesada K, et al. (1999). "A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator.". EMBO J. 18 (9): 2551–62. doi:10.1093/emboj/18.9.2551. PMID 10228168. 
  • Mohler PJ, Kreda SM, Boucher RC, et al. (1999). "Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50.". J. Cell Biol. 147 (4): 879–90. PMID 10562288. 
  • Espanel X, Sudol M (2001). "Yes-associated protein and p53-binding protein-2 interact through their WW and SH3 domains.". J. Biol. Chem. 276 (17): 14514–23. doi:10.1074/jbc.M008568200. PMID 11278422. 
  • Strano S, Munarriz E, Rossi M, et al. (2001). "Physical interaction with Yes-associated protein enhances p73 transcriptional activity.". J. Biol. Chem. 276 (18): 15164–73. doi:10.1074/jbc.M010484200. PMID 11278685. 
  • Vassilev A, Kaneko KJ, Shu H, et al. (2001). "TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm.". Genes Dev. 15 (10): 1229–41. doi:10.1101/gad.888601. PMID 11358867. 
  • Pires JR, Taha-Nejad F, Toepert F, et al. (2002). "Solution structures of the YAP65 WW domain and the variant L30 K in complex with the peptides GTPPPPYTVG, N-(n-octyl)-GPPPY and PLPPY and the application of peptide libraries reveal a minimal binding epitope.". J. Mol. Biol. 314 (5): 1147–56. doi:10.1006/jmbi.2000.5199. PMID 11743730. 
  • Ferrigno O, Lallemand F, Verrecchia F, et al. (2002). "Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.". Oncogene 21 (32): 4879–84. doi:10.1038/sj.onc.1205623. PMID 12118366. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Basu S, Totty NF, Irwin MS, et al. (2003). "Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.". Mol. Cell 11 (1): 11–23. PMID 12535517. 
  • Komuro A, Nagai M, Navin NE, Sudol M (2003). "WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus.". J. Biol. Chem. 278 (35): 33334–41. doi:10.1074/jbc.M305597200. PMID 12807903. 
  • Omerovic J, Puggioni EM, Napoletano S, et al. (2004). "Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level.". Exp. Cell Res. 294 (2): 469–79. doi:10.1016/j.yexcr.2003.12.002. PMID 15023535. 
  • Howell M, Borchers C, Milgram SL (2004). "Heterogeneous nuclear ribonuclear protein U associates with YAP and regulates its co-activation of Bax transcription.". J. Biol. Chem. 279 (25): 26300–6. doi:10.1074/jbc.M401070200. PMID 15096513. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660. 
  • Levy D, Adamovich Y, Reuven N, Shaul Y. (2007). "The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73.". Cell Death and Differentiation. 14 (4): 743–51. doi:10.1038/sj.cdd.4402063. PMID 17110958. 
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