YAF2

From Wikipedia, the free encyclopedia

YY1 associated factor 2

PDB rendering based on 2d9g.

Available structures: 2d9g

Identifiers

Symbol(s)

YAF2; MGC41856

External IDs

OMIM: 607534 MGI: 1914307 HomoloGene: 4203

Gene ontology
Molecular Function:	• transcription coactivator activity • transcription corepressor activity • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• intracellular • nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent • negative regulation of transcription • positive regulation of transcription

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001012424 (mRNA)
NP_001012424 (protein)

XM_001003112 (mRNA)
XP_001003112 (protein)

Location

Chr 12: 40.84 - 40.92 Mb

Chr 15: 93.11 - 93.17 Mb

Pubmed search

[1]

[2]

YY1 associated factor 2, also known as YAF2, is a human gene.^[1]

The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1.^[1]

[edit] References

^ ^a ^b Entrez Gene: YAF2 YY1 associated factor 2.

[edit] Further reading

Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mädge B, Geisen C, Möröy T, Schwab M (2003). "Yaf2 inhibits Myc biological function.". Cancer Lett. 193 (2): 171–6. PMID 12706874.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ogawa H, Ishiguro K, Gaubatz S, et al. (2002). "A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells.". Science 296 (5570): 1132–6. doi:10.1126/science.1069861. PMID 12004135.
Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
Bannasch D, Mädge B, Schwab M (2001). "Functional interaction of Yaf2 with the central region of MycN.". Oncogene 20 (41): 5913–9. doi:10.1038/sj.onc.1204747. PMID 11593398.
Kalenik JL, Chen D, Bradley ME, et al. (1997). "Yeast two-hybrid cloning of a novel zinc finger protein that interacts with the multifunctional transcription factor YY1.". Nucleic Acids Res. 25 (4): 843–9. PMID 9016636.