XRCC6

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X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa)
PDB rendering based on 1jeq.
Available structures: 1jeq, 1jey
Identifiers
Symbol(s)	XRCC6; CTC75; CTCBF; G22P1; KU70; ML8; TLAA
External IDs	OMIM: 152690 MGI: 95606 HomoloGene: 37483
Gene ontology Molecular Function: • DNA binding • double-stranded DNA binding • ATP-dependent DNA helicase activity • protein binding Cellular Component: • membrane fraction • nucleus • transcription factor complex • DNA-dependent protein kinase complex Biological Process: • DNA ligation • DNA repair • double-strand break repair via nonhomologous end joining • DNA recombination • positive regulation of transcription, DNA-dependent
Orthologs
	Human	Mouse
Entrez	2547	14375
Ensembl	n/a	ENSMUSG00000022471
Uniprot	n/a	Q3UJL8
Refseq	NM_001469 (mRNA) NP_001460 (protein)	NM_010247 (mRNA) NP_034377 (protein)
Location	n/a	Chr 15: 81.84 - 81.87 Mb
Pubmed search	[1]	[2]

X-ray repair complementing defective repair in Chinese hamster cells 6 (Ku autoantigen, 70kDa), also known as XRCC6, is a human gene.

The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus.^[1]

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