XRCC3

From Wikipedia, the free encyclopedia

X-ray repair complementing defective repair in Chinese hamster cells 3

Identifiers

External IDs

OMIM: 600675 MGI: 1921585 HomoloGene: 36178

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • ATP binding • DNA-dependent ATPase activity
Cellular Component:	• nucleus
Biological Process:	• DNA repair • DNA recombination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005432 (mRNA)
NP_005423 (protein)

NM_028875 (mRNA)
NP_083151 (protein)

Location

Chr 14: 103.23 - 103.25 Mb

Chr 12: 112.25 - 112.26 Mb

Pubmed search

[1]

[2]

X-ray repair complementing defective repair in Chinese hamster cells 3, also known as XRCC3, is a human gene.

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.^[1]

[edit] References

^ Entrez Gene: XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3.

[edit] Further reading

Kopecný J (1976). "[Rational approaches to the treatment of urinary incontinence (author's transl)]". Ceskoslovenská gynekologie 41 (6): 408–9. PMID 975276.
Tebbs RS, Zhao Y, Tucker JD, et al. (1995). "Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene.". Proc. Natl. Acad. Sci. U.S.A. 92 (14): 6354–8. PMID 7603995.
Price EA, Bourne SL, Radbourne R, et al. (1998). "Rare microsatellite polymorphisms in the DNA repair genes XRCC1, XRCC3 and XRCC5 associated with cancer in patients of varying radiosensitivity.". Somat. Cell Mol. Genet. 23 (4): 237–47. PMID 9542526.
Liu N, Lamerdin JE, Tebbs RS, et al. (1998). "XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages.". Mol. Cell 1 (6): 783–93. PMID 9660962.
Pierce AJ, Johnson RD, Thompson LH, Jasin M (1999). "XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.". Genes Dev. 13 (20): 2633–8. PMID 10541549.
Winsey SL, Haldar NA, Marsh HP, et al. (2000). "A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.". Cancer Res. 60 (20): 5612–6. PMID 11059748.
Kurumizaka H, Ikawa S, Nakada M, et al. (2001). "Homologous-pairing activity of the human DNA-repair proteins Xrcc3.Rad51C.". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5538–43. doi:10.1073/pnas.091603098. PMID 11331762.
Masson JY, Stasiak AZ, Stasiak A, et al. (2001). "Complex formation by the human RAD51C and XRCC3 recombination repair proteins.". Proc. Natl. Acad. Sci. U.S.A. 98 (15): 8440–6. doi:10.1073/pnas.111005698. PMID 11459987.
Miller KA, Yoshikawa DM, McConnell IR, et al. (2002). "RAD51C interacts with RAD51B and is central to a larger protein complex in vivo exclusive of RAD51.". J. Biol. Chem. 277 (10): 8406–11. doi:10.1074/jbc.M108306200. PMID 11744692.
Liu N, Schild D, Thelen MP, Thompson LH (2002). "Involvement of Rad51C in two distinct protein complexes of Rad51 paralogs in human cells.". Nucleic Acids Res. 30 (4): 1009–15. PMID 11842113.
Shen H, Sturgis EM, Dahlstrom KR, et al. (2002). "A variant of the DNA repair gene XRCC3 and risk of squamous cell carcinoma of the head and neck: a case-control analysis.". Int. J. Cancer 99 (6): 869–72. doi:10.1002/ijc.10413. PMID 12115490.
Duan Z, Shen H, Lee JE, et al. (2002). "DNA repair gene XRCC3 241Met variant is not associated with risk of cutaneous malignant melanoma.". Cancer Epidemiol. Biomarkers Prev. 11 (10 Pt 1): 1142–3. PMID 12376526.
Seedhouse C, Bainton R, Lewis M, et al. (2003). "The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia.". Blood 100 (10): 3761–6. doi:10.1182/blood-2002-04-1152. PMID 12393447.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Smith TR, Miller MS, Lohman K, et al. (2003). "Polymorphisms of XRCC1 and XRCC3 genes and susceptibility to breast cancer.". Cancer Lett. 190 (2): 183–90. PMID 12565173.
Jacobsen NR, Nexø BA, Olsen A, et al. (2004). "No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer.". Cancer Epidemiol. Biomarkers Prev. 12 (6): 584–5. PMID 12815008.
Zhu G, Duffy DL, Turner DR, et al. (2005). "Linkage and association analysis of radiation damage repair genes XRCC3 and XRCC5 with nevus density in adolescent twins.". Twin research : the official journal of the International Society for Twin Studies 6 (4): 315–21. doi:10.1375/136905203322296683. PMID 14511439.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bertram CG, Gaut RM, Barrett JH, et al. (2004). "An assessment of a variant of the DNA repair gene XRCC3 as a possible nevus or melanoma susceptibility genotype.". J. Invest. Dermatol. 122 (2): 429–32. doi:10.1046/j.0022-202X.2003.12541.x. PMID 15009726.
Tarsounas M, Davies AA, West SC (2004). "RAD51 localization and activation following DNA damage.". Philos. Trans. R. Soc. Lond., B, Biol. Sci. 359 (1441): 87–93. doi:10.1098/rstb.2003.1368. PMID 15065660.