XPOT

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Exportin, tRNA (nuclear export receptor for tRNAs)
Identifiers
Symbol(s) XPOT; XPO3
External IDs OMIM: 603180 MGI: 1920442 HomoloGene: 38291
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 11260 73192
Ensembl ENSG00000184575 ENSMUSG00000034667
Uniprot O43592 Q9CRT8
Refseq NM_007235 (mRNA)
NP_009166 (protein)		 XM_125902 (mRNA)
XP_125902 (protein)
Location Chr 12: 63.08 - 63.13 Mb Chr 10: 120.99 - 121.02 Mb
Pubmed search [1] [2]

Exportin, tRNA (nuclear export receptor for tRNAs), also known as XPOT, is a human gene.[1]

This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.[1]

[edit] References

  1. ^ a b Entrez Gene: XPOT exportin, tRNA (nuclear export receptor for tRNAs).

[edit] Further reading

  • Arts GJ, Fornerod M, Mattaj IW (1998). "Identification of a nuclear export receptor for tRNA.". Curr. Biol. 8 (6): 305–14. PMID 9512417. 
  • Kutay U, Lipowsky G, Izaurralde E, et al. (1998). "Identification of a tRNA-specific nuclear export receptor.". Mol. Cell 1 (3): 359–69. PMID 9660920. 
  • Arts GJ, Kuersten S, Romby P, et al. (1999). "The role of exportin-t in selective nuclear export of mature tRNAs.". EMBO J. 17 (24): 7430–41. doi:10.1093/emboj/17.24.7430. PMID 9857198. 
  • Kruse C, Willkomm DK, Grünweller A, et al. (2000). "Export and transport of tRNA are coupled to a multi-protein complex.". Biochem. J. 346 Pt 1: 107–15. PMID 10657246. 
  • Kutay U, Hartmann E, Treichel N, et al. (2001). "Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.". J. Biol. Chem. 275 (51): 40163–8. doi:10.1074/jbc.M006242200. PMID 11024021. 
  • Kuersten S, Arts GJ, Walther TC, et al. (2002). "Steady-state nuclear localization of exportin-t involves RanGTP binding and two distinct nuclear pore complex interaction domains.". Mol. Cell. Biol. 22 (16): 5708–20. PMID 12138183. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Suzuki T, Koyama Y, Hayakawa S, et al. (2006). "1,25-Dihydroxyvitamin D3 suppresses exportin expression in human promyelocytic leukemia HL-60 cells.". Biomed. Res. 27 (2): 89–92. PMID 16707848. 
  • Li S, Sprinzl M (2007). "Interaction of immobilized human exportin-t with calf liver tRNA.". RNA Biol 3 (4): 145–9. PMID 17224653. 
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