XPO1

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Exportin 1 (CRM1 homolog, yeast)
PDB rendering based on 1w9c.
Available structures: 1w9c
Identifiers
Symbol(s)	XPO1; CRM1; DKFZp686B1823
External IDs	OMIM: 602559 MGI: 2144013 HomoloGene: 2554
Gene ontology Molecular Function: • RNA binding • protein binding • protein transporter activity Cellular Component: • nucleus • nuclear envelope • nuclear pore • nucleoplasm • cytoplasm Biological Process: • protein import into nucleus, docking • protein export from nucleus • intracellular protein transport • mRNA transport
RNA expression pattern
More reference expression data
Orthologs
	Human	Mouse
Entrez	7514	103573
Ensembl	ENSG00000082898	ENSMUSG00000020290
Uniprot	O14980	Q8BYY5
Refseq	NM_003400 (mRNA) NP_003391 (protein)	NM_001035226 (mRNA) NP_001030303 (protein)
Location	Chr 2: 61.56 - 61.62 Mb	Chr 11: 23.16 - 23.2 Mb
Pubmed search	[1]	[2]

Exportin 1 (CRM1 homolog, yeast), also known as XPO1, is a human gene.

The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.^[1]

[edit] See also

• Karyopherin

[edit] References

[edit] Further reading