XPC (gene)

From Wikipedia, the free encyclopedia

Xeroderma pigmentosum, complementation group C

Identifiers

XPC; XP3; XPCC

External IDs

OMIM: 278720 MGI: 103557 HomoloGene: 3401

Gene ontology
Molecular Function:	• damaged DNA binding • single-stranded DNA binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• nucleotide-excision repair • intra-S DNA damage checkpoint

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004628 (mRNA)
NP_004619 (protein)

NM_009531 (mRNA)
NP_033557 (protein)

Location

Chr 3: 14.16 - 14.2 Mb

Chr 6: 91.45 - 91.48 Mb

Pubmed search

[1]

[2]

Xeroderma pigmentosum, complementation group C, also known as XPC, is a human gene involved in the recognition of bulky DNA adducts in Nucleotide Excision Repair.^[1]

[edit] References

^ Entrez Gene: XPC xeroderma pigmentosum, complementation group C.

[edit] Further reading

Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.". Hum. Mutat. 14 (1): 9-22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
El-Deiry WS (2003). "Transactivation of repair genes by BRCA1.". Cancer Biol. Ther. 1 (5): 490-1. PMID 12496474.
Sugasawa K (2007). "UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair.". J. Mol. Histol. 37 (5-7): 189-202. doi:10.1007/s10735-006-9044-7. PMID 16858626.
Legerski R, Peterson C (1993). "Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C.". Nature 360 (6404): 610. doi:10.1038/360610b0. PMID 1461286.
Legerski R, Peterson C (1992). "Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C.". Nature 359 (6390): 70-3. doi:10.1038/359070a0. PMID 1522891.
Legerski RJ, Liu P, Li L, et al. (1994). "Assignment of xeroderma pigmentosum group C (XPC) gene to chromosome 3p25.". Genomics 21 (1): 266-9. doi:10.1006/geno.1994.1256. PMID 8088800.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Masutani C, Sugasawa K, Yanagisawa J, et al. (1994). "Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.". EMBO J. 13 (8): 1831-43. PMID 8168482.
Li L, Bales ES, Peterson CA, Legerski RJ (1994). "Characterization of molecular defects in xeroderma pigmentosum group C.". Nat. Genet. 5 (4): 413-7. doi:10.1038/ng1293-413. PMID 8298653.
Li L, Peterson C, Legerski R (1996). "Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene.". Nucleic Acids Res. 24 (6): 1026-8. PMID 8604333.
van der Spek PJ, Eker A, Rademakers S, et al. (1996). "XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes.". Nucleic Acids Res. 24 (13): 2551-9. PMID 8692695.
Li L, Lu X, Peterson C, Legerski R (1997). "XPC interacts with both HHR23B and HHR23A in vivo.". Mutat. Res. 383 (3): 197-203. PMID 9164480.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Zeng L, Quilliet X, Chevallier-Lagente O, et al. (1998). "Retrovirus-mediated gene transfer corrects DNA repair defect of xeroderma pigmentosum cells of complementation groups A, B and C.". Gene Ther. 4 (10): 1077-84. doi:10.1038/sj.gt.3300495. PMID 9415314.
Khan SG, Levy HL, Legerski R, et al. (1998). "Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia.". J. Invest. Dermatol. 111 (5): 791-6. doi:10.1046/j.1523-1747.1998.00391.x. PMID 9804340.
Yokoi M, Masutani C, Maekawa T, et al. (2000). "The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA.". J. Biol. Chem. 275 (13): 9870-5. PMID 10734143.
Batty D, Rapic'-Otrin V, Levine AS, Wood RD (2000). "Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.". J. Mol. Biol. 300 (2): 275-90. doi:10.1006/jmbi.2000.3857. PMID 10873465.
Araújo SJ, Nigg EA, Wood RD (2001). "Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.". Mol. Cell. Biol. 21 (7): 2281-91. doi:10.1128/MCB.21.7.2281-2291.2001. PMID 11259578.
Araki M, Masutani C, Takemura M, et al. (2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair.". J. Biol. Chem. 276 (22): 18665-72. doi:10.1074/jbc.M100855200. PMID 11279143.