XPA

From Wikipedia, the free encyclopedia

Xeroderma pigmentosum, complementation group A

PDB rendering based on 1d4u.

Available structures: 1d4u, 1xpa

Identifiers

Symbol(s)

XPA; XP1; XPAC

External IDs

OMIM: 278700 MGI: 99135 HomoloGene: 37298

Gene ontology
Molecular Function:	• damaged DNA binding • protein binding • zinc ion binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• nucleotide-excision repair • response to oxidative stress

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000380 (mRNA)
NP_000371 (protein)

NM_011728 (mRNA)
NP_035858 (protein)

Location

Chr 9: 99.48 - 99.5 Mb

Chr 4: 46.18 - 46.22 Mb

Pubmed search

[1]

[2]

Xeroderma pigmentosum, complementation group A, also known as XPA, is a human gene.^[1]

[edit] References

^ Entrez Gene: XPA xeroderma pigmentosum, complementation group A.

[edit] Further reading

Cleaver JE, Thompson LH, Richardson AS, States JC (1999). "A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy.". Hum. Mutat. 14 (1): 9–22. doi:10.1002/(SICI)1098-1004(1999)14:1<9::AID-HUMU2>3.0.CO;2-6. PMID 10447254.
Morikawa K, Shirakawa M (2000). "Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA.". Mutat. Res. 460 (3-4): 257–75. PMID 10946233.
Satokata I, Tanaka K, Okada Y (1992). "Molecular basis of group A xeroderma pigmentosum: a missense mutation and two deletions located in a zinc finger consensus sequence of the XPAC gene.". Hum. Genet. 88 (6): 603–7. PMID 1339397.
Satokata I, Tanaka K, Yuba S, Okada Y (1992). "Identification of splicing mutations of the last nucleotides of exons, a nonsense mutation, and a missense mutation of the XPAC gene as causes of group A xeroderma pigmentosum.". Mutat. Res. 273 (2): 203–12. PMID 1372103.
Miyamoto I, Miura N, Niwa H, et al. (1992). "Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair.". J. Biol. Chem. 267 (17): 12182–7. PMID 1601884.
Satokata I, Tanaka K, Miura N, et al. (1991). "Characterization of a splicing mutation in group A xeroderma pigmentosum.". Proc. Natl. Acad. Sci. U.S.A. 87 (24): 9908–12. PMID 1702221.
Miura N, Miyamoto I, Asahina H, et al. (1991). "Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene.". J. Biol. Chem. 266 (29): 19786–9. PMID 1918083.
Tanaka K, Miura N, Satokata I, et al. (1990). "Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain.". Nature 348 (6296): 73–6. doi:10.1038/348073a0. PMID 2234061.
Li L, Lu X, Peterson CA, Legerski RJ (1995). "An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair.". Mol. Cell. Biol. 15 (10): 5396–402. PMID 7565690.
Nagai A, Saijo M, Kuraoka I, et al. (1995). "Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein.". Biochem. Biophys. Res. Commun. 211 (3): 960–6. PMID 7598728.
Farndon PA, Morris DJ, Hardy C, et al. (1995). "Analysis of 133 meioses places the genes for nevoid basal cell carcinoma (Gorlin) syndrome and Fanconi anemia group C in a 2.6-cM interval and contributes to the fine map of 9q22.3.". Genomics 23 (2): 486–9. doi:10.1006/geno.1994.1528. PMID 7835901.
Park CH, Mu D, Reardon JT, Sancar A (1995). "The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor.". J. Biol. Chem. 270 (9): 4896–902. PMID 7876263.
Li L, Elledge SJ, Peterson CA, et al. (1994). "Specific association between the human DNA repair proteins XPA and ERCC1.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5012–6. PMID 8197174.
Park CH, Sancar A (1994). "Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins.". Proc. Natl. Acad. Sci. U.S.A. 91 (11): 5017–21. PMID 8197175.
Satokata I, Iwai K, Matsuda T, et al. (1994). "Genomic characterization of the human DNA excision repair-controlling gene XPAC.". Gene 136 (1-2): 345–8. PMID 8294029.
Tanaka K (1993). "The Japan Society of Human Genetics Award Lecture. Molecular analysis of xeroderma pigmentosum group A gene.". Jpn. J. Hum. Genet. 38 (1): 1–14. PMID 8504220.
Topping RS, Myrand SP, Williams BL, et al. (1996). "Characterization of the human XPA promoter.". Gene 166 (2): 341–2. PMID 8543191.
Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3.". Genomics 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
Selby CP, Sancar A (1997). "Human transcription-repair coupling factor CSB/ERCC6 is a DNA-stimulated ATPase but is not a helicase and does not disrupt the ternary transcription complex of stalled RNA polymerase II.". J. Biol. Chem. 272 (3): 1885–90. PMID 8999876.
Hayashi T, Takao M, Tanaka K, Yasui A (1998). "ERCC1 mutations in UV-sensitive Chinese hamster ovary (CHO) cell lines.". Mutat. Res. 407 (3): 269–76. PMID 9653453.