Xenobiotic-transporting ATPase

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In enzymology, a xenobiotic-transporting ATPase (EC 3.6.3.44) is an enzyme that catalyzes the chemical reaction

ATP + H₂O + xenobioticin $\rightleftharpoons$ ADP + phosphate + xenobioticout

The 3 substrates of this enzyme are ATP, H₂O, and xenobiotic, whereas its 3 products are ADP, phosphate, and xenobiotic.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (xenobiotic-exporting). Other names in common use include multidrug-resistance protein, MDR protein, P-glycoprotein, pleiotropic-drug-resistance protein, PDR protein, steroid-transporting ATPase, and ATP phosphohydrolase (steroid-exporting).

[edit] References

IUBMB entry for 3.6.3.44
BRENDA references for 3.6.3.44 (Recommended.)
PubMed references for 3.6.3.44
PubMed Central references for 3.6.3.44
Google Scholar references for 3.6.3.44
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Mahe Y, Lemoine Y, Kuchler K (1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo". J. Biol. Chem. 271: 25167–72. doi:10.1074/jbc.271.41.25167. PMID 8810273.