XAGE1D

From Wikipedia, the free encyclopedia

X antigen family, member 1

Identifiers

XAGE1; GAGED2; XAGE-1

External IDs

Gene ontology

Orthologs

Human

Mouse

Entrez

9503

n/a

Refseq

NM_020411 (mRNA)
NP_065144 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

X antigen family, member 1, also known as XAGE1, is a human gene.^[1]

This gene is a member of the XAGE subfamily, which belongs to the GAGE family. The GAGE genes are expressed in a variety of tumors and in some fetal and reproductive tissues. This gene is strongly expressed in Ewing's sarcoma, alveolar rhabdomyosarcoma and normal testis. The protein encoded by this gene contains a nuclear localization signal and shares a sequence similarity with other GAGE/PAGE proteins. Because of the expression pattern and the sequence similarity, this protein also belongs to a family of CT (cancer-testis) antigens. Alternative splicing of this gene generates 3 transcript variants, and one of which includes 2 transcripts generated from alternate transcription initiation sites.^[1]

[edit] References

^ ^a ^b Entrez Gene: XAGE1 X antigen family, member 1.

[edit] Further reading

Brinkmann U, Vasmatzis G, Lee B, Pastan I (1999). "Novel genes in the PAGE and GAGE family of tumor antigens found by homology walking in the dbEST database.". Cancer Res. 59 (7): 1445–8. PMID 10197611.
Liu XF, Helman LJ, Yeung C, et al. (2000). "XAGE-1, a new gene that is frequently expressed in Ewing's sarcoma.". Cancer Res. 60 (17): 4752–5. PMID 10987281.
Zendman AJ, van Kraats AA, den Hollander AI, et al. (2002). "Characterization of XAGE-1b, a short major transcript of cancer/testis-associated gene XAGE-1, induced in melanoma metastasis.". Int. J. Cancer 97 (2): 195–204. PMID 11774264.
Zendman AJ, Van Kraats AA, Weidle UH, et al. (2002). "The XAGE family of cancer/testis-associated genes: alignment and expression profile in normal tissues, melanoma lesions and Ewing's sarcoma.". Int. J. Cancer 99 (3): 361–9. doi:10.1002/ijc.10371. PMID 11992404.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Egland KA, Kumar V, Duray P, Pastan I (2003). "Characterization of overlapping XAGE-1 transcripts encoding a cancer testis antigen expressed in lung, breast, and other types of cancers.". Mol. Cancer Ther. 1 (7): 441–50. PMID 12479262.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651.
Lim JH, Kim SP, Gabrielson E, et al. (2005). "Activation of human cancer/testis antigen gene, XAGE-1, in tumor cells is correlated with CpG island hypomethylation.". Int. J. Cancer 116 (2): 200–6. doi:10.1002/ijc.21007. PMID 15800911.
Nakagawa K, Noguchi Y, Uenaka A, et al. (2006). "XAGE-1 expression in non-small cell lung cancer and antibody response in patients.". Clin. Cancer Res. 11 (15): 5496–503. doi:10.1158/1078-0432.CCR-05-0216. PMID 16061866.
Sato S, Noguchi Y, Ohara N, et al. (2007). "Identification of XAGE-1 isoforms: predominant expression of XAGE-1b in testis and tumors.". Cancer Immun. 7: 5. PMID 17335148.