WTAP (gene)

From Wikipedia, the free encyclopedia


Wilms tumor 1 associated protein
Identifiers
Symbol(s) WTAP; DKFZp686F20131; KIAA0105; MGC3925
External IDs OMIM: 605442 MGI: 1926395 HomoloGene: 68422
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9589 60532
Ensembl ENSG00000146457 ENSMUSG00000061897
Uniprot Q15007 n/a
Refseq NM_004906 (mRNA)
NP_004897 (protein)		 NM_175394 (mRNA)
NP_780603 (protein)
Location Chr 6: 160.07 - 160.1 Mb Chr 2: 179.11 - 179.11 Mb
Pubmed search [1] [2]

Wilms tumor 1 associated protein, also known as WTAP, is a human gene.[1]

The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in three transcript variants, two of which encode the same isoform.[1]

[edit] References

  1. ^ a b Entrez Gene: WTAP Wilms tumor 1 associated protein.

[edit] Further reading

  • Small TW, Bolender Z, Bueno C, et al. (2007). "Wilms' tumor 1-associating protein regulates the proliferation of vascular smooth muscle cells.". Circ. Res. 99 (12): 1338–46. doi:10.1161/01.RES.0000252289.79841.d3. PMID 17095724. 
  • Horiuchi K, Umetani M, Minami T, et al. (2007). "Wilms' tumor 1-associating protein regulates G2/M transition through stabilization of cyclin A2 mRNA.". Proc. Natl. Acad. Sci. U.S.A. 103 (46): 17278–83. doi:10.1073/pnas.0608357103. PMID 17088532. 
  • Rong Y, Cheng L, Ning H, et al. (2007). "Wilms' tumor 1 and signal transducers and activators of transcription 3 synergistically promote cell proliferation: a possible mechanism in sporadic Wilms' tumor.". Cancer Res. 66 (16): 8049–57. doi:10.1158/0008-5472.CAN-06-1172. PMID 16912181. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Obuse C, Yang H, Nozaki N, et al. (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase.". Genes Cells 9 (2): 105–20. PMID 15009096. 
  • Utsch B, Kaya A, Ozburun A, et al. (2004). "Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias.". Scand. J. Urol. Nephrol. 37 (6): 498–501. doi:10.1080/00365590310014517. PMID 14675924. 
  • Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.". J. Biol. Chem. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ortega A, Niksic M, Bachi A, et al. (2003). "Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing.". J. Biol. Chem. 278 (5): 3040–7. doi:10.1074/jbc.M210737200. PMID 12444081. 
  • Little NA, Hastie ND, Davies RC (2001). "Identification of WTAP, a novel Wilms' tumour 1-associating protein.". Hum. Mol. Genet. 9 (15): 2231–9. PMID 11001926. 
  • Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins.". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595. 
  • Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527. 
 This article on a gene on chromosome 6 is a stub. You can help Wikipedia by expanding it.