WSB1

From Wikipedia, the free encyclopedia

WD repeat and SOCS box-containing 1

Identifiers

WSB1; SWIP1; WSB-1

External IDs

OMIM: 610091 MGI: 1926139 HomoloGene: 9218

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• cellular_component • intracellular
Biological Process:	• intracellular signaling cascade • biological_process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015626 (mRNA)
NP_056441 (protein)

NM_001042565 (mRNA)
NP_001036030 (protein)

Location

Chr 17: 22.65 - 22.66 Mb

Chr 11: 79.06 - 79.07 Mb

Pubmed search

[1]

[2]

WD repeat and SOCS box-containing 1, also known as WSB1, is a human gene.^[1]

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: WSB1 WD repeat and SOCS box-containing 1.

[edit] Further reading

Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation.". Trends Biochem. Sci. 27 (5): 235–41. PMID 12076535.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Vasiliauskas D, Hancock S, Stern CD (1999). "SWiP-1: novel SOCS box containing WD-protein regulated by signalling centres and by Shh during development.". Mech. Dev. 82 (1-2): 79–94. PMID 10354473.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
Kamura T, Burian D, Yan Q, et al. (2001). "Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase.". J. Biol. Chem. 276 (32): 29748–53. doi:10.1074/jbc.M103093200. PMID 11384984.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Dentice M, Bandyopadhyay A, Gereben B, et al. (2005). "The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.". Nat. Cell Biol. 7 (7): 698–705. doi:10.1038/ncb1272. PMID 15965468.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Woo JS, Imm JH, Min CK, et al. (2006). "Structural and functional insights into the B30.2/SPRY domain.". EMBO J. 25 (6): 1353–63. doi:10.1038/sj.emboj.7600994. PMID 16498413.
Chen QR, Bilke S, Wei JS, et al. (2006). "Increased WSB1 copy number correlates with its over-expression which associates with increased survival in neuroblastoma.". Genes Chromosomes Cancer 45 (9): 856–62. doi:10.1002/gcc.20349. PMID 16804916.