WRNIP1

From Wikipedia, the free encyclopedia

Werner helicase interacting protein 1

Identifiers

WRNIP1; FLJ22526; RP11-420G6.2; WHIP; bA420G6.2

External IDs

OMIM: 608196 MGI: 1926153 HomoloGene: 10592

Gene ontology
Molecular Function:	• nucleotide binding • DNA binding • protein binding • ATP binding • hydrolase activity • ATPase activity
Cellular Component:	• nucleus
Biological Process:	• DNA synthesis during DNA repair • regulation of DNA replication initiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_020135 (mRNA)
NP_064520 (protein)

NM_030215 (mRNA)
NP_084491 (protein)

Location

Chr 6: 2.71 - 2.73 Mb

Chr 13: 32.81 - 32.83 Mb

Pubmed search

[1]

[2]

Werner helicase interacting protein 1, also known as WRNIP1, is a human gene.^[1]

Werner's syndrome is a rare autosomal recessive disorder characterized by premature aging. The protein encoded by this gene interacts with the N-terminal portion of Werner protein containing the exonuclease domain. This protein shows homology to replication factor C family proteins, and is conserved from E. coli to human. Studies in yeast suggest that this gene may influence the aging process. Two transcript variants encoding different isoforms have been isolated for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: WRNIP1 Werner helicase interacting protein 1.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Kawabe Yi , Branzei D, Hayashi T, et al. (2001). "A novel protein interacts with the Werner's syndrome gene product physically and functionally.". J. Biol. Chem. 276 (23): 20364–9. doi:10.1074/jbc.C100035200. PMID 11301316.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
Tsurimoto T, Shinozaki A, Yano M, et al. (2005). "Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.". Genes Cells 10 (1): 13–22. doi:10.1111/j.1365-2443.2004.00812.x. PMID 15670210.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Bish RA, Myers MP (2007). "Werner helicase-interacting protein 1 binds polyubiquitin via its zinc finger domain.". J. Biol. Chem. 282 (32): 23184–93. doi:10.1074/jbc.M701042200. PMID 17550899.