Talk:Wortmannin
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[edit] MAPK and wortmannin
Not sure if this is true. Is MAPK inhibited by Wortmannin? It's not a commonly described target of wortmannin. What concentration is required to inhibit MAPK? Jagowins 17:47, 19 January 2006 (UTC)
Why not? read this: Adv Exp Med Biol. 1996;416:321-6. PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. Ferby I, Waga I, Kume K, Sakanaka C, Shimizu T.
AbuAmir 12:25, 30 April 2006 (UTC)
Maybe it would be a good idea for *someone* to put that reference in the article where the claim is made... Aaadddaaammm 09:12, 4 September 2006 (UTC)
I'm almost positive that Wortmannin has a longer half-life than 10 minutes. In the lab I work for, we use it in cell culture for 48-hour treatments and still see its effect as an inhibitor. Someone might want to reevaluate that tid-bit on the page describing Wortmannin.
[edit] Specific Inhibitor
I would argue that since Wortmannin inhibits : "mTOR, DNA-PK, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) at high concentrations as well as members of the polo-like kinase family with IC50 in the same range as for PI3K." I will change this in a couple of days if no-one has any objections. ImmunolPhD 08:19, 26 July 2007 (UTC)
[edit] Wortmannin derivates going preclinicals
Please comrades, add a section about that. AbuAmir (talk) 12:10, 15 April 2008 (UTC)