WNT9A

From Wikipedia, the free encyclopedia

Wingless-type MMTV integration site family, member 9A

Identifiers

WNT9A; MGC138165; MGC141991; WNT14

External IDs

OMIM: 602863 MGI: 2446084 HomoloGene: 20722

Gene ontology
Molecular Function:	• signal transducer activity • extracellular matrix structural constituent
Cellular Component:	• extracellular region
Biological Process:	• Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • multicellular organismal development • embryonic arm morphogenesis

Orthologs

Human

Mouse

Refseq

NM_003395 (mRNA)
NP_003386 (protein)

NM_139298 (mRNA)
NP_647459 (protein)

Location

Chr 1: 226.17 - 226.2 Mb

Chr 11: 59.12 - 59.15 Mb

Pubmed search

[1]

[2]

Wingless-type MMTV integration site family, member 9A, also known as WNT9A, is a human gene.^[1]

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNT9A wingless-type MMTV integration site family, member 9A.

[edit] Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267-75. PMID 8167409.
Bergstein I, Eisenberg LM, Bhalerao J, et al. (1998). "Isolation of two novel WNT genes, WNT14 and WNT15, one of which (WNT15) is closely linked to WNT3 on human chromosome 17q21.". Genomics 46 (3): 450-8. doi:10.1006/geno.1997.5041. PMID 9441749.
Hartmann C, Tabin CJ (2001). "Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton.". Cell 104 (3): 341-51. PMID 11239392.
Saitoh T, Hirai M, Katoh M (2001). "Molecular cloning and characterization of WNT3A and WNT14 clustered in human chromosome 1q42 region.". Biochem. Biophys. Res. Commun. 284 (5): 1168-75. doi:10.1006/bbrc.2001.5105. PMID 11414706.
Katoh M (2002). "Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster.". Int. J. Mol. Med. 9 (3): 221-7. PMID 11836627.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Qian J, Jiang Z, Li M, et al. (2003). "Mouse Wnt9b transforming activity, tissue-specific expression, and evolution.". Genomics 81 (1): 34-46. PMID 12573259.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Katoh Y, Katoh M (2005). "Comparative genomics on Wnt9a orthologs.". Oncol. Rep. 13 (5): 989-92. PMID 15809769.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315-21. doi:10.1038/nature04727. PMID 16710414.
Bhattacharyya S, Borthakur A, Dudeja PK, Tobacman JK (2007). "Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes.". Dig. Dis. Sci. 52 (10): 2766-74. doi:10.1007/s10620-006-9531-4. PMID 17429723.