WNT7B

From Wikipedia, the free encyclopedia

Wingless-type MMTV integration site family, member 7B

Identifiers

External IDs

OMIM: 601967 MGI: 98962 HomoloGene: 22531

Gene ontology
Molecular Function:	• signal transducer activity • extracellular matrix structural constituent
Cellular Component:	• extracellular region
Biological Process:	• Wnt receptor signaling pathway, calcium modulating pathway • cell-cell signaling • multicellular organismal development

Orthologs

Human

Mouse

n/a

Refseq

NM_058238 (mRNA)
NP_478679 (protein)

NM_009528 (mRNA)
NP_033554 (protein)

Location

n/a

Chr 15: 85.36 - 85.41 Mb

Pubmed search

[1]

[2]

Wingless-type MMTV integration site family, member 7B, also known as WNT7B, is a human gene.^[1]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.^[1]

[edit] References

^ ^a ^b Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B.

[edit] Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. PMID 8167409.
Huguet EL, McMahon JA, McMahon AP, et al. (1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue.". Cancer Res. 54 (10): 2615–21. PMID 8168088.
van Bokhoven H, Kissing J, Schepens M, et al. (1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization.". Cytogenet. Cell Genet. 77 (3-4): 288–9. PMID 9284940.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.". Eur. J. Biochem. 267 (13): 4300–11. PMID 10866835.
Kirikoshi H, Sekihara H, Katoh M (2001). "Molecular cloning and characterization of human WNT7B.". Int. J. Oncol. 19 (4): 779–83. PMID 11562755.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Capurro MI, Shi W, Sandal S, Filmus J (2006). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.". J. Biol. Chem. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID 16227623.